MUSHROOM BIOHACKER PACK * BUY 4 GET 1 FREE *
This is the Ultimate Biohacker Value Pack 🙌
Includes the following Double Liquid Extracts:
~ Lion's Mane ~ Cordyceps ~ Reishi ~ Turkey Tail ~ Shiitake ~ (120ml each)
INCLUDES FREE SHIPPING ON BOTH NATIONAL AND INTERNATIONAL ORDERS!
GET THE SET
MUSHROOM BIOHACKER PACK * BUY 4 GET 1 FREE *
This is the Ultimate Biohacker Value Pack 🙌
Includes the following Double Liquid Extracts:
~ Lion's Mane ~ Cordyceps ~ Reishi ~ Turkey Tail ~ Shiitake ~ (120ml each)
INCLUDES FREE SHIPPING ON BOTH NATIONAL AND INTERNATIONAL ORDERS!
GET THE SETOur most popular products
Lion's Mane Mushroom Liquid Extract
{"id":1661964845125,"title":"Lion's Mane Mushroom Liquid Extract","handle":"lions-mane-mushroom-liquid-extract","description":"\u003ch1\u003eThe Tale of Lion’s Mane Mushroom\u003c\/h1\u003e\n\u003cp\u003eThe Lion’s Mane mushroom, is one of the most powerful in the kingdom of fungi. It is an easily recognisable mushroom due to its unique and beautiful appearance, resembling a lion’s mane \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/258850466_Neurotrophic_Properties_of_the_Lion's_Mane_Medicinal_Mushroom_Hericium_erinaceus_Higher_Basidiomycetes_from_Malaysia\" target=\"_blank\" title=\"Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e,\u003ca href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.6b00371\" target=\"_blank\" title=\"Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides.\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e2\u003c\/a\u003e]\u003c\/span\u003e. \u003cbr\u003e \u003cbr\u003e Lion’s mane mushroom is a delicious edible fungus, with plentiful beneficial properties. For these reasons, the mushroom has been used for centuries in Chinese culture. The Lion’s mane mushroom has great nutritional and medicinal value and therefore the mushroom been a major component in traditional medicine \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[3]\u003c\/a\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eThe Use of Lion’s Mane Liquid Extract\u003c\/h2\u003e\n\u003cp\u003eThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.6b00371\" target=\"_blank\" title=\"Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides.\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e.\u003c\/span\u003e As is the effortless way of incorporating these mushroom extracts into your day to day life. This Lion’s Mane liquid extract makes the bioactive compounds within the mushroom readily available to you, to tackle any challenge that may be thrown your way! \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5b02914\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e.\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003e\u003cbr\u003eThe unique beneficial properties of Lion’s mane mushroom has led it to be considered as the king of fungi. The popularity of Lion’s mane is mainly related to its potential positive effects on the nervous system and brain health. Therefore Lion’s Mane mushroom extracts were highly respected in traditional medicine, it is said that the mushroom has the ability to sharpen one’s concentration and memory. Further research shows that there are many more health benefits from this mushroom to be discovered \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.6b00371\" target=\"_blank\" title=\"Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides.\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e\u003c\/span\u003e.\u003c\/p\u003e\n\u003ch3\u003e The Benefits of Lion’s Mane Mushroom\u003c\/h3\u003e\n\u003cp\u003eAs the Lion’s Mane mushroom started to become globally popular, there has been extensive research into Lion’s Mane mushroom benefits and the properties the mushroom holds.\u003c\/p\u003e\n\u003cp\u003eThis Lion’s mane mushroom shows to contain an abundance of polysaccharides and secondary metabolites such as erinacines and diterpenes, allowing this magnificent mushroom to support neural growth, reduce inflammation, support anti-bacterial and antioxidant activity \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/258850466_Neurotrophic_Properties_of_the_Lion's_Mane_Medicinal_Mushroom_Hericium_erinaceus_Higher_Basidiomycetes_from_Malaysia\" target=\"_blank\" title=\"Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e,\u003ca href=\"https:\/\/www.semanticscholar.org\/paper\/The-Anti-Inflammatory-Effects-of-Lion's-Mane-in-a-Mori-Ouchi\/dba8bd796b26329195d29b3f1351cdffcfdee85f\" target=\"_blank\" title=\"The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e5,\u003c\/a\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/301568748_Comparative_studies_on_extracts_from_Hericium_erinaceus_by_different_polarity_reagents_to_gain_higher_antioxidant_activities\" target=\"_blank\" title=\"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e6\u003c\/a\u003e]\u003c\/span\u003e and has also been said to improve sleep quality (Click \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/podcasts.apple.com\/us\/podcast\/mushrooms-are-your-new-anti-aging-strategy-life-cykel-603\/id451295014?i=1000442712896\" title=\"Mushroom podcast\" style=\"color: #00aaff;\"\u003e\u003cu\u003ehere\u003c\/u\u003e\u003c\/a\u003e\u003c\/span\u003e to listen to biohacker Dave Asprey talk mushrooms) and mood \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/www.hindawi.com\/journals\/ecam\/2019\/7861297\/\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[7\u003c\/a\u003e,\u003ca href=\"https:\/\/www.researchgate.net\/publication\/317430783_Medicinal_Mushrooms_in_Human_Clinical_Studies_Part_I_Anticancer_Oncoimmunological_and_Immunomodulatory_Activities_A_Review\" target=\"_blank\" title=\"Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e8\u003c\/a\u003e]\u003c\/span\u003e. This mushroom can give your brain the food it deserves!\u003c\/p\u003e\n\u003cp\u003eTo delve deeper into the world of fungi and to learn more about Lion’s Mane mushrooms and other functional mushrooms, follow this \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\" style=\"color: #00aaff;\"\u003e\u003cu\u003elink \u003c\/u\u003e\u003c\/a\u003e\u003c\/span\u003eto read our latest blogs . . . . . .\u003c\/p\u003e\n\u003ch4\u003eYour Lion’s Mane Liquid Double Extract\u003c\/h4\u003e\n\u003cp\u003eThere are a growing number of people seeking Lion’s Mane mushroom extracts for its beneficial effects. That’s why we are bringing to you our very own Australian sourced Lion’s Mane (\u003cem\u003eH. coralloides.) \u003c\/em\u003eliquid double extract.\u003c\/p\u003e\n\u003cp\u003e Are you interested to a buy Lion's Mane Mushroom extract?\u003c\/p\u003e\n\u003cp\u003eIf you want to buy Lion's Mane mushroom extracts, one of Australia’s most unique products, you are at the right place...\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCustomer feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e“I started using Lion’s Mane to improve my concentration and focus and after 5 days noticed a significant positive change in my attention span and work output. Plus as an added bonus my cognitive memory of the dreams I had also improved.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Leigh Kelly, Bondi\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add Lion’s Mane liquid double extract directly to your coffee, smoothie, tea or water for best results.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml \u003c\/p\u003e\n\u003cp\u003eLife Cykel's Lion’s Mane mushrooms and liquid double extracts are grown and engineered in the Northern Rivers, NSW.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle (60 day supply \u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Australian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eDistilled Water, Organic Alcohol,\u003c\/span\u003e\u003cspan\u003e Australian \u003c\/span\u003e\u003cem\u003eHericium coralloides\u003cspan\u003e.\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e (\u003c\/span\u003e\u003cem\u003eHericium coralloides\u003cspan\u003e.\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eMycelial Biomass,\u003ci\u003e\u003c\/i\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eHericium coralloides\u003cspan\u003e.\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e Fruiting Body), Natural Wild Harvest Kakadu Plum \u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a cool, dry place\u003c\/p\u003e\n\u003cp\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMushroom research:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Chang, S.-T. and Wasser, S.P. (2012). The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 14(2), pp.95–134.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [6] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eExperimental and Therapeutic Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 12(1), pp.513–517.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eKim, S. P.; Kang, M. Y.; Kim, J. H.; Nam, S. H.; Friedman, M. Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice. J. Agric. Food Chem. 2011, 59, 9861−9869\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[8] Vigna, L., Morelli, F., Agnelli, G.M., Napolitano, F., Ratto, D., Occhinegro, A., Di Iorio, C., Savino, E., Girometta, C., Brandalise, F. and Rossi, P. (2019). Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eEvidence-Based Complementary and Alternative Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 2019, pp.1–12.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[9] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eWasser, S.P. (2017). Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 19(4), pp.279–317.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003col\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003cspan\u003e* This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T21:40:54+11:00","created_at":"2018-10-03T20:33:06+10:00","vendor":"Life Cykel","type":"","tags":[],"price":3495,"price_min":3495,"price_max":5295,"available":true,"price_varies":true,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":31070746968124,"title":"120ml","option1":"120ml","option2":null,"option3":null,"sku":"LMDE120ml-1","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Lion's Mane Mushroom Liquid Extract - 120ml","public_title":"120ml","options":["120ml"],"price":5295,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"705632689165"},{"id":31070756896828,"title":"60ml","option1":"60ml","option2":null,"option3":null,"sku":"LMDE60ml","requires_shipping":true,"taxable":true,"featured_image":{"id":13341048340540,"product_id":1661964845125,"position":3,"created_at":"2019-10-31T15:07:29+11:00","updated_at":"2019-10-31T15:07:29+11:00","alt":null,"width":1349,"height":1500,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.lions.60ml.png?v=1572494849","variant_ids":[31070756896828]},"available":true,"name":"Lion's Mane Mushroom Liquid Extract - 60ml","public_title":"60ml","options":["60ml"],"price":3495,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"0793591711225"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Lion_s_Mane_Extract_e962b04f-2c56-421a-af91-55a5552b9eb7.jpg?v=1564227561","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/lion_s_mane_mushroom_dbbe7312-99db-4598-96cf-1b4ab65bdf35.jpg?v=1564227561","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.lions.60ml.png?v=1572494849"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Lion_s_Mane_Extract_e962b04f-2c56-421a-af91-55a5552b9eb7.jpg?v=1564227561","options":["Size"],"content":"\u003ch1\u003eThe Tale of Lion’s Mane Mushroom\u003c\/h1\u003e\n\u003cp\u003eThe Lion’s Mane mushroom, is one of the most powerful in the kingdom of fungi. It is an easily recognisable mushroom due to its unique and beautiful appearance, resembling a lion’s mane \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/258850466_Neurotrophic_Properties_of_the_Lion's_Mane_Medicinal_Mushroom_Hericium_erinaceus_Higher_Basidiomycetes_from_Malaysia\" target=\"_blank\" title=\"Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e,\u003ca href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.6b00371\" target=\"_blank\" title=\"Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides.\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e2\u003c\/a\u003e]\u003c\/span\u003e. \u003cbr\u003e \u003cbr\u003e Lion’s mane mushroom is a delicious edible fungus, with plentiful beneficial properties. For these reasons, the mushroom has been used for centuries in Chinese culture. The Lion’s mane mushroom has great nutritional and medicinal value and therefore the mushroom been a major component in traditional medicine \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[3]\u003c\/a\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eThe Use of Lion’s Mane Liquid Extract\u003c\/h2\u003e\n\u003cp\u003eThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.6b00371\" target=\"_blank\" title=\"Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides.\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e.\u003c\/span\u003e As is the effortless way of incorporating these mushroom extracts into your day to day life. This Lion’s Mane liquid extract makes the bioactive compounds within the mushroom readily available to you, to tackle any challenge that may be thrown your way! \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.5b02914\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e.\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003e\u003cbr\u003eThe unique beneficial properties of Lion’s mane mushroom has led it to be considered as the king of fungi. The popularity of Lion’s mane is mainly related to its potential positive effects on the nervous system and brain health. Therefore Lion’s Mane mushroom extracts were highly respected in traditional medicine, it is said that the mushroom has the ability to sharpen one’s concentration and memory. Further research shows that there are many more health benefits from this mushroom to be discovered \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.6b00371\" target=\"_blank\" title=\"Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides.\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e\u003c\/span\u003e.\u003c\/p\u003e\n\u003ch3\u003e The Benefits of Lion’s Mane Mushroom\u003c\/h3\u003e\n\u003cp\u003eAs the Lion’s Mane mushroom started to become globally popular, there has been extensive research into Lion’s Mane mushroom benefits and the properties the mushroom holds.\u003c\/p\u003e\n\u003cp\u003eThis Lion’s mane mushroom shows to contain an abundance of polysaccharides and secondary metabolites such as erinacines and diterpenes, allowing this magnificent mushroom to support neural growth, reduce inflammation, support anti-bacterial and antioxidant activity \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/258850466_Neurotrophic_Properties_of_the_Lion's_Mane_Medicinal_Mushroom_Hericium_erinaceus_Higher_Basidiomycetes_from_Malaysia\" target=\"_blank\" title=\"Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e,\u003ca href=\"https:\/\/www.semanticscholar.org\/paper\/The-Anti-Inflammatory-Effects-of-Lion's-Mane-in-a-Mori-Ouchi\/dba8bd796b26329195d29b3f1351cdffcfdee85f\" target=\"_blank\" title=\"The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e5,\u003c\/a\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/301568748_Comparative_studies_on_extracts_from_Hericium_erinaceus_by_different_polarity_reagents_to_gain_higher_antioxidant_activities\" target=\"_blank\" title=\"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e6\u003c\/a\u003e]\u003c\/span\u003e and has also been said to improve sleep quality (Click \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/podcasts.apple.com\/us\/podcast\/mushrooms-are-your-new-anti-aging-strategy-life-cykel-603\/id451295014?i=1000442712896\" title=\"Mushroom podcast\" style=\"color: #00aaff;\"\u003e\u003cu\u003ehere\u003c\/u\u003e\u003c\/a\u003e\u003c\/span\u003e to listen to biohacker Dave Asprey talk mushrooms) and mood \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/www.hindawi.com\/journals\/ecam\/2019\/7861297\/\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[7\u003c\/a\u003e,\u003ca href=\"https:\/\/www.researchgate.net\/publication\/317430783_Medicinal_Mushrooms_in_Human_Clinical_Studies_Part_I_Anticancer_Oncoimmunological_and_Immunomodulatory_Activities_A_Review\" target=\"_blank\" title=\"Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e8\u003c\/a\u003e]\u003c\/span\u003e. This mushroom can give your brain the food it deserves!\u003c\/p\u003e\n\u003cp\u003eTo delve deeper into the world of fungi and to learn more about Lion’s Mane mushrooms and other functional mushrooms, follow this \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\" style=\"color: #00aaff;\"\u003e\u003cu\u003elink \u003c\/u\u003e\u003c\/a\u003e\u003c\/span\u003eto read our latest blogs . . . . . .\u003c\/p\u003e\n\u003ch4\u003eYour Lion’s Mane Liquid Double Extract\u003c\/h4\u003e\n\u003cp\u003eThere are a growing number of people seeking Lion’s Mane mushroom extracts for its beneficial effects. That’s why we are bringing to you our very own Australian sourced Lion’s Mane (\u003cem\u003eH. coralloides.) \u003c\/em\u003eliquid double extract.\u003c\/p\u003e\n\u003cp\u003e Are you interested to a buy Lion's Mane Mushroom extract?\u003c\/p\u003e\n\u003cp\u003eIf you want to buy Lion's Mane mushroom extracts, one of Australia’s most unique products, you are at the right place...\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCustomer feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e“I started using Lion’s Mane to improve my concentration and focus and after 5 days noticed a significant positive change in my attention span and work output. Plus as an added bonus my cognitive memory of the dreams I had also improved.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Leigh Kelly, Bondi\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add Lion’s Mane liquid double extract directly to your coffee, smoothie, tea or water for best results.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml \u003c\/p\u003e\n\u003cp\u003eLife Cykel's Lion’s Mane mushrooms and liquid double extracts are grown and engineered in the Northern Rivers, NSW.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle (60 day supply \u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Australian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eDistilled Water, Organic Alcohol,\u003c\/span\u003e\u003cspan\u003e Australian \u003c\/span\u003e\u003cem\u003eHericium coralloides\u003cspan\u003e.\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e (\u003c\/span\u003e\u003cem\u003eHericium coralloides\u003cspan\u003e.\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eMycelial Biomass,\u003ci\u003e\u003c\/i\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eHericium coralloides\u003cspan\u003e.\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e Fruiting Body), Natural Wild Harvest Kakadu Plum \u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a cool, dry place\u003c\/p\u003e\n\u003cp\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMushroom research:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Chang, S.-T. and Wasser, S.P. (2012). The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 14(2), pp.95–134.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [6] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eExperimental and Therapeutic Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 12(1), pp.513–517.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eKim, S. P.; Kang, M. Y.; Kim, J. H.; Nam, S. H.; Friedman, M. Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice. J. Agric. Food Chem. 2011, 59, 9861−9869\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[8] Vigna, L., Morelli, F., Agnelli, G.M., Napolitano, F., Ratto, D., Occhinegro, A., Di Iorio, C., Savino, E., Girometta, C., Brandalise, F. and Rossi, P. (2019). Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eEvidence-Based Complementary and Alternative Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 2019, pp.1–12.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[9] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eWasser, S.P. (2017). Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 19(4), pp.279–317.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003col\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003cspan\u003e* This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/details\u003e"} [{"id":92048490565,"handle":"all","title":"All","updated_at":"2019-11-18T23:35:01+11:00","body_html":"","published_at":"2019-02-18T10:20:43+11:00","sort_order":"best-selling","template_suffix":"","disjunctive":false,"rules":[{"column":"variant_price","relation":"greater_than","condition":"0"},{"column":"variant_inventory","relation":"greater_than","condition":"0"},{"column":"type","relation":"not_equals","condition":"Insurance"}],"published_scope":"web"},{"id":80859955269,"handle":"liquid-extracts","title":"Liquid Mushroom Extract - The Elixir of Life","updated_at":"2019-11-18T23:35:01+11:00","body_html":"\u003cp\u003eGive your body and mind proper support on your journey to vitality and longevity. Find the best organic liquid Mushroom extracts at Life Cykel today!\u003c\/p\u003e\n\u003cp\u003eFor thousands of years, traditional medicine has used mushroom tinctures as a primary means of treatment, due to the vast array of health benefits they provide. The positive outcomes and the strong faith in the power of the mushroom liquid extract, has gained them the title ”\u003cstrong\u003e\u003cem\u003eelixirs of life\u003c\/em\u003e\u003c\/strong\u003e”. These beneficial mushrooms have mainly been used in Asia \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e, but are now spreading to all corners of the world, and are being named \u003cstrong\u003e\u003cem\u003efunctional mushrooms.\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdetails\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eFunctional mushrooms are considered a superfood and are now commonly used as dietary supplements \u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09168451.2018.1431519?journalCode=tbbb20\" target=\"_blank\" title=\"Biologically functional molecules from mushroom-forming fungi. \" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003eToday, we are discovering more and more about the benefits of using these mushrooms and extensive research is being undertaken to understand the bioactive compounds within the mushrooms that provide them with such power.\u003c\/p\u003e\n\u003cp\u003e By using Life Cykel’s mushroom liquid extract, as a supplement in your everyday diet, you can effortlessly give your body and mind the proper support it requires on your mission of health and wellness.\u003c\/p\u003e\n\u003cp\u003e Life Cykel's liquid \u003cstrong\u003e\u003cem\u003edouble\u003c\/em\u003e\u003c\/strong\u003e extracts have been carefully created to be some of the most potent mushroom extracts in the world. Our extract range includes Reishi, Cordyceps, Shiitake, Lion's Mane and Turkey Tail mushrooms.\u003c\/p\u003e\n\u003cp\u003eNot only do we provide you with the best mushroom liquid extract, when producing our extracts we aim to integrate Circular Economy principles wherever possible and where available we're using Australian native mushroom strains that have been meticulously infused with Australian native, wild harvested Kakadu Plum.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/lions-mane-mushroom-liquid-extract\" title=\"Buy Lion's Mane Liquid Extract\"\u003eLion’s Mane Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eLion's Mane Mushroom is known for its positive effects on cognitive health \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24266378\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" rel=\"noopener noreferrer\"\u003e[3]\u003c\/a\u003e. This mushroom is rich in bioactive components \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26244378\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" rel=\"noopener noreferrer\"\u003e[5]\u003c\/a\u003e, which could be responsible for some important physiological activities, this includes antioxidant and anti- inflammatory activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26559695\" title=\"The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\"\u003e [6\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906890\/\" target=\"_blank\" title=\"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities\" rel=\"noopener noreferrer\"\u003e7]\u003c\/a\u003e and neural growth \u003ca href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jnatprod.6b00371?src=recsys\" target=\"_blank\" title=\"Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e, improving memory and focus as well as enhancing your dreams and mood \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31118969\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?\" rel=\"noopener noreferrer\"\u003e[8]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/cordyceps-mushroom-liquid-extract\" title=\"Buy Cordyceps Liquid Extract\"\u003eCordyceps Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eCordyceps mushroom is an extraordinary mushroom. The bioactive compounds within the mushroom, show to promote anti-inflammatory, anti-microbial and anti-oxidative activities (anti-ageing) [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=86265\" target=\"_blank\" title=\"The Effect of the Hot Water Extracts of the Paecilomyces hepiali and Cordyceps militaris Mycelia on the Growth of Gastrointestinal Bacteria\" rel=\"noopener noreferrer\"\u003e10]\u003c\/a\u003e, as well as having beneficial effects on lipid metabolism [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24231073\" target=\"_blank\" title=\"Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice.\" rel=\"noopener noreferrer\"\u003e11]\u003c\/a\u003e and may improve your endurance to prolonged and high intensity exercise \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e[9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5236007\/\" target=\"_blank\" title=\"Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation\" rel=\"noopener noreferrer\"\u003e12\u003c\/a\u003e,\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28094746\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming.\" rel=\"noopener noreferrer\"\u003e13\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/reishi-mushroom-liquid-extract\" title=\"Buy Reishi Liquid Extract\"\u003eReishi Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eFor many millennia the Reishi mushroom has been used to treat a variety of diseases, including cardiovascular diseases and insomnia \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e[14]\u003c\/a\u003e. The constituents within the mushroom may help to enhance anti-microbial, anti-oxidant and immunomodulating activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e [14\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ingentaconnect.com\/contentone\/ben\/cpb\/2016\/00000017\/00000003\/art00010\" target=\"_blank\" title=\"Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents\" rel=\"noopener noreferrer\"\u003e15\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24386913\" target=\"_blank\" title=\"Concentration variation and molecular characteristics of soluble (1,3;1,6)-β-D-glucans in submerged cultivation products of Ganoderma lucidum mycelium\" rel=\"noopener noreferrer\"\u003e16\u003c\/a\u003e]. The mushroom is also well known for its beneficial effects on sleep and relaxation [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e17\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Extract+of+Ganoderma+lucidum+prolongs+sleep+time+in+rats\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats\" rel=\"noopener noreferrer\"\u003e18\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/turkey-tail-mushroom-liquid-extract\" title=\"Buy Turkey Tail Liquid Extract\"\u003eTurkey Tail Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eThe Turkey Tail mushroom is mainly consumed to regulate the immune system. However, more recent research is also showing evidence that the mushroom may have the ability of modulating the composition of the human microbiome [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25006989\" target=\"_blank\" title=\"Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial\" rel=\"noopener noreferrer\"\u003e19\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23435630\" target=\"_blank\" title=\"Trametes versicolor extract modifies human fecal microbiota composition in vitro.\" rel=\"noopener noreferrer\"\u003e20]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/shiitake-mushroom-liquid-extract\" title=\"Buy Shiitake Liquid Extract\"\u003eShiitake mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eShiitake mushrooms have been utilised for their anti-sclerotic (reduce hardening of arteries) activities as well as helping to reduce damage from UV light and helping to increase the renewal process of the skin, therefore this mushroom could be considered as an effective anti-photoaging and skin care ingredient \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\"L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e[21,\u003c\/a\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\"l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study\" rel=\"noopener noreferrer\"\u003e 22,\u003c\/a\u003e \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e23]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eLearn more about our mushrooms by browsing our range of liquid mushroom extracts below or click \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003ehere\u003c\/u\u003e\u003c\/a\u003e to read our latest blogs on these fantastic fungi!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2] Choi, J.-H. (2018). Biologically functional molecules from mushroom-forming fungi. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eBioscience, Biotechnology, and Biochemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 82(3), pp.372–382.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [8] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eExperimental and Therapeutic Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 12(1), pp.513–517.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[9] Das, S.K., Masuda, M., Sakurai, A. and Sakakibara, M. (2010). Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eFitoterapia\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 81(8), pp.961–968.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[10] Ko and Leung. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[11] Gamage, S., Nakayama, J., Fuyuno, Y. and Ohga, S. (2018). The Effect of the Hot Water Extracts of the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePaecilomyces hepiali \u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003eand \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCordyceps militaris\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e Mycelia on the Growth of Gastrointestinal Bacteria. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdvances in Microbiology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 08(07), pp.490–505.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[12] Kim, S.B., Ahn, B., Kim, M., Ji, H.-J., Shin, S.-K., Hong, I.P., Kim, C.Y., Hwang, B.Y. and Lee, M.K. (2014). Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 151(1), pp.478–484.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [13] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[14] Cilerdzic, J., Stajic, M. and Vukojevic, J. (2016). Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCurrent Pharmaceutical Biotechnology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(3), pp.275–282.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[15] Wang, C.-H., Hsieh, S.-C., Wang, H.-J., Chen, M.-L., Lin, B.-F., Chiang, B.-H. and Lu, T.-J. (2014). Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 62(3), pp.634–641.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[16] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[17] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[18] Pallav, K., Dowd, S.E., Villafuerte, J., Yang, X., Kabbani, T., Hansen, J., Dennis, M., Leffler, D.A., Newburg, D.S. and Kelly, C.P. (2014). Effects of polysaccharopeptide fromTrametes Versicolorand amoxicillin on the gut microbiome of healthy volunteers. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eGut Microbes\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 5(4), pp.458–467.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[19] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePlant Foods for Human Nutrition\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 68(2), pp.107–112\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[20] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eNachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[21] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[22] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T22:45:41+11:00","sort_order":"best-selling","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-03T21:01:43+10:00","alt":"","width":2657,"height":2657,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/Reishi_Liquid_Extract.jpg?v=1561725306"}},{"id":81919148101,"handle":"our-most-popular-products","title":"Our most popular products","updated_at":"2019-11-18T23:35:01+11:00","body_html":"","published_at":"2018-10-09T20:31:53+11:00","sort_order":"manual","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-09T21:38:37+11:00","alt":"","width":1000,"height":1061,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/mushroom-box-grown_9f7cd2ae-9917-4975-be1f-7e05481b2d9d.jpg?v=1539081517"}}]$34.95 AUD
Turkey Tail Mushroom Liquid Extract
{"id":1659981529157,"title":"Turkey Tail Mushroom Liquid Extract","handle":"turkey-tail-mushroom-liquid-extract","description":"\u003ch1\u003eTURKEY TAIL TIME \u003c\/h1\u003e\n\u003ch3\u003e\u003cstrong\u003eHonour your gut with Turkey Tail Mushroom Liquid Extract\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe Turkey Tail mushroom is an extremely abundant mushroom found predominantly in temperate forests.The mushroom has been seen in Chinese medicinal literature for centuries, used to treat a wide array of diseases. The name of the mushroom originates from its appearance, as the mushroom fruiting body resembles the fanned out tail of a turkey as it grows on decaying trees \u003ca href=\"https:\/\/www.dropbox.com\/home\/Scientific%20Litterature\/Turkey%20Tail?preview=yu2013.pdf\" target=\"_blank\" title=\"ORIGINAL PAPER Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003eThe Benefits of Turkey Tail Mushroom\u003c\/h3\u003e\n\u003cp\u003eThe bioactive compounds within the Turkey Tail Mushroom that promote beneficial physiological activities are beta-glucans, mainly polysaccharopeptide (PSP) and Polysaccharide Krestin (PSK). These beta-glucans are not readily digestible by human intestinal enzymes, however they are thought to enhance the colonisation of good bacteria within the gut which can in turn modulate the immune system and provide abundant health benefits \u003ca href=\"https:\/\/www.dropbox.com\/home\/Scientific%20Litterature\/Turkey%20Tail?preview=yu2013.pdf\" target=\"_blank\" title=\"ORIGINAL PAPER Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e, \u003ca href=\"http:\/\/citeseerx.ist.psu.edu\/viewdoc\/download?doi=10.1.1.1015.6128\u0026amp;rep=rep1\u0026amp;type=pdf\" target=\"_blank\" title=\"Gut bacteria and health foods—the European perspective\" rel=\"noopener noreferrer\"\u003e2]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eKrestin is also seen to promote the activity of leukocytes, a key agent in immune cell response \u003ca href=\"https:\/\/academic.oup.com\/nutritionreviews\/article\/67\/11\/624\/1850752\" target=\"_blank\" title=\"Beta-glucans in higher fungi and their health effects\" rel=\"noopener noreferrer\"\u003e[3\u003c\/a\u003e]. Further, the Turkey tail mushroom produces an enzyme called Laccase, which has potent antioxidative activity \u003ca href=\"https:\/\/aem.asm.org\/content\/aem\/62\/12\/4563.full.pdf\" target=\"_blank\" title=\"Oxidation of Anthracene and Benzo[a]pyrene by Laccases from Trametes versicolor\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eTo delve deeper into the world of fungi and to learn more about Turkey Tail mushrooms and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003elink \u003c\/u\u003e\u003c\/a\u003eto read our latest blogs \u003c\/p\u003e\n\u003ch3\u003eThe Use of Turkey Tail Liquid Extract\u003c\/h3\u003e\n\u003cp\u003eThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today. As is the effortless way of incorporating these mushroom extracts into your day to day life. Turkey Tail liquid extract makes the bioactive compounds within the mushroom readily available to you!\u003c\/p\u003e\n\u003cp\u003e If the Turkey Tail mushroom sounds like the perfect mushroom for you, don’t waste one more minute and buy our Turkey Tail liquid extract here today and give your tummy some love!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSome of our customers include: airplane travellers, young families, city people, prebiotic enthusiasts, balanced humans, gut focused people, partiers, seekers of immunity, talkers, walkers, workers and contributors.\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003eCustomer Feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\"As a passionate medical professional, I am constantly looking at the research to find the best health solutions for my patients. I have found both on a personal and professional level Life Cykel's Turkey Tail to not only have subjective positive outcomes but objective clinical outcomes highlighting the gut microbiome modulating effects when looking at pre \u0026amp; post intervention microbiome testing.\"\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Dr Jeremy Princi, Gut Health Specialist, Bunbury\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eLife Cykel's Turkey Tail mushrooms and extracts are grown and engineered in the Northern Rivers, NSW.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add Turkey Tail liquid double extract directly to your coffee, smoothie, tea, soup broth or water in the morning for best results.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml \u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle \u003cspan\u003e(60 day supply\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Australian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e Distilled Water, Alcohol, Australian \u003ci\u003eTrametes versicolor. \u003c\/i\u003e(\u003ci\u003eTrametes versicolor. \u003c\/i\u003eMycelial Biomass, Tra\u003ci\u003emetes versicolor. \u003c\/i\u003eFruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage: \u003c\/strong\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMushroom Research: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[1] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ePlant Foods for Human Nutrition\u003c\/i\u003e, 68(2), pp.107–112.\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[2] Saarela, M., Lähteenmäki, L., Crittenden, R., Salminen, S. and Mattila-Sandholm, T. (2002). Gut bacteria and health foods—the European perspective.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eInternational Journal of Food Microbiology\u003c\/i\u003e, 78(1–2), pp.99–117.\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[3] Rop, O., Mlcek, J. and Jurikova, T. (2009). Beta-glucans in higher fungi and their health effects.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eNutrition Reviews\u003c\/i\u003e, 67(11), pp.624–631.\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[4] Dodor, D.E., Hwang, H.-M. and Ekunwe, S.I.. (2004). Oxidation of anthracene and benzo[a]pyrene by immobilized laccase from Trametes versicolor.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eEnzyme and Microbial Technology\u003c\/i\u003e, 35(2–3), pp.210–217.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e \u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003c\/span\u003e\u003c\/p\u003e","published_at":"2019-02-25T21:57:30+11:00","created_at":"2018-10-03T12:54:56+10:00","vendor":"Life Cykel","type":"","tags":[],"price":3495,"price_min":3495,"price_max":5295,"available":true,"price_varies":true,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":31070784979004,"title":"120ml","option1":"120ml","option2":null,"option3":null,"sku":"TTDE120ml-1","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Turkey Tail Mushroom Liquid Extract - 120ml","public_title":"120ml","options":["120ml"],"price":5295,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"705632689196"},{"id":31070789632060,"title":"60ml","option1":"60ml","option2":null,"option3":null,"sku":"TTDE60ml","requires_shipping":true,"taxable":true,"featured_image":{"id":13341092184124,"product_id":1659981529157,"position":3,"created_at":"2019-10-31T15:15:57+11:00","updated_at":"2019-10-31T15:15:57+11:00","alt":null,"width":1166,"height":1500,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.turkey.60ml.png?v=1572495357","variant_ids":[31070789632060]},"available":true,"name":"Turkey Tail Mushroom Liquid Extract - 60ml","public_title":"60ml","options":["60ml"],"price":3495,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"0793591581804"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Turkey_Tail_Extract_f921761e-a2a1-4b82-8cb2-bf21878ac341.jpg?v=1564227704","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/turkey_tail.jpg?v=1564227704","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.turkey.60ml.png?v=1572495357"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Turkey_Tail_Extract_f921761e-a2a1-4b82-8cb2-bf21878ac341.jpg?v=1564227704","options":["Size"],"content":"\u003ch1\u003eTURKEY TAIL TIME \u003c\/h1\u003e\n\u003ch3\u003e\u003cstrong\u003eHonour your gut with Turkey Tail Mushroom Liquid Extract\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe Turkey Tail mushroom is an extremely abundant mushroom found predominantly in temperate forests.The mushroom has been seen in Chinese medicinal literature for centuries, used to treat a wide array of diseases. The name of the mushroom originates from its appearance, as the mushroom fruiting body resembles the fanned out tail of a turkey as it grows on decaying trees \u003ca href=\"https:\/\/www.dropbox.com\/home\/Scientific%20Litterature\/Turkey%20Tail?preview=yu2013.pdf\" target=\"_blank\" title=\"ORIGINAL PAPER Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003eThe Benefits of Turkey Tail Mushroom\u003c\/h3\u003e\n\u003cp\u003eThe bioactive compounds within the Turkey Tail Mushroom that promote beneficial physiological activities are beta-glucans, mainly polysaccharopeptide (PSP) and Polysaccharide Krestin (PSK). These beta-glucans are not readily digestible by human intestinal enzymes, however they are thought to enhance the colonisation of good bacteria within the gut which can in turn modulate the immune system and provide abundant health benefits \u003ca href=\"https:\/\/www.dropbox.com\/home\/Scientific%20Litterature\/Turkey%20Tail?preview=yu2013.pdf\" target=\"_blank\" title=\"ORIGINAL PAPER Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e, \u003ca href=\"http:\/\/citeseerx.ist.psu.edu\/viewdoc\/download?doi=10.1.1.1015.6128\u0026amp;rep=rep1\u0026amp;type=pdf\" target=\"_blank\" title=\"Gut bacteria and health foods—the European perspective\" rel=\"noopener noreferrer\"\u003e2]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eKrestin is also seen to promote the activity of leukocytes, a key agent in immune cell response \u003ca href=\"https:\/\/academic.oup.com\/nutritionreviews\/article\/67\/11\/624\/1850752\" target=\"_blank\" title=\"Beta-glucans in higher fungi and their health effects\" rel=\"noopener noreferrer\"\u003e[3\u003c\/a\u003e]. Further, the Turkey tail mushroom produces an enzyme called Laccase, which has potent antioxidative activity \u003ca href=\"https:\/\/aem.asm.org\/content\/aem\/62\/12\/4563.full.pdf\" target=\"_blank\" title=\"Oxidation of Anthracene and Benzo[a]pyrene by Laccases from Trametes versicolor\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eTo delve deeper into the world of fungi and to learn more about Turkey Tail mushrooms and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003elink \u003c\/u\u003e\u003c\/a\u003eto read our latest blogs \u003c\/p\u003e\n\u003ch3\u003eThe Use of Turkey Tail Liquid Extract\u003c\/h3\u003e\n\u003cp\u003eThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today. As is the effortless way of incorporating these mushroom extracts into your day to day life. Turkey Tail liquid extract makes the bioactive compounds within the mushroom readily available to you!\u003c\/p\u003e\n\u003cp\u003e If the Turkey Tail mushroom sounds like the perfect mushroom for you, don’t waste one more minute and buy our Turkey Tail liquid extract here today and give your tummy some love!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSome of our customers include: airplane travellers, young families, city people, prebiotic enthusiasts, balanced humans, gut focused people, partiers, seekers of immunity, talkers, walkers, workers and contributors.\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003eCustomer Feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\"As a passionate medical professional, I am constantly looking at the research to find the best health solutions for my patients. I have found both on a personal and professional level Life Cykel's Turkey Tail to not only have subjective positive outcomes but objective clinical outcomes highlighting the gut microbiome modulating effects when looking at pre \u0026amp; post intervention microbiome testing.\"\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Dr Jeremy Princi, Gut Health Specialist, Bunbury\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eLife Cykel's Turkey Tail mushrooms and extracts are grown and engineered in the Northern Rivers, NSW.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add Turkey Tail liquid double extract directly to your coffee, smoothie, tea, soup broth or water in the morning for best results.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml \u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle \u003cspan\u003e(60 day supply\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Australian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e Distilled Water, Alcohol, Australian \u003ci\u003eTrametes versicolor. \u003c\/i\u003e(\u003ci\u003eTrametes versicolor. \u003c\/i\u003eMycelial Biomass, Tra\u003ci\u003emetes versicolor. \u003c\/i\u003eFruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage: \u003c\/strong\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMushroom Research: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[1] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ePlant Foods for Human Nutrition\u003c\/i\u003e, 68(2), pp.107–112.\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[2] Saarela, M., Lähteenmäki, L., Crittenden, R., Salminen, S. and Mattila-Sandholm, T. (2002). Gut bacteria and health foods—the European perspective.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eInternational Journal of Food Microbiology\u003c\/i\u003e, 78(1–2), pp.99–117.\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[3] Rop, O., Mlcek, J. and Jurikova, T. (2009). Beta-glucans in higher fungi and their health effects.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eNutrition Reviews\u003c\/i\u003e, 67(11), pp.624–631.\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[4] Dodor, D.E., Hwang, H.-M. and Ekunwe, S.I.. (2004). Oxidation of anthracene and benzo[a]pyrene by immobilized laccase from Trametes versicolor.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eEnzyme and Microbial Technology\u003c\/i\u003e, 35(2–3), pp.210–217.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e \u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003c\/span\u003e\u003c\/p\u003e"} [{"id":92048490565,"handle":"all","title":"All","updated_at":"2019-11-18T23:35:01+11:00","body_html":"","published_at":"2019-02-18T10:20:43+11:00","sort_order":"best-selling","template_suffix":"","disjunctive":false,"rules":[{"column":"variant_price","relation":"greater_than","condition":"0"},{"column":"variant_inventory","relation":"greater_than","condition":"0"},{"column":"type","relation":"not_equals","condition":"Insurance"}],"published_scope":"web"},{"id":80859955269,"handle":"liquid-extracts","title":"Liquid Mushroom Extract - The Elixir of Life","updated_at":"2019-11-18T23:35:01+11:00","body_html":"\u003cp\u003eGive your body and mind proper support on your journey to vitality and longevity. Find the best organic liquid Mushroom extracts at Life Cykel today!\u003c\/p\u003e\n\u003cp\u003eFor thousands of years, traditional medicine has used mushroom tinctures as a primary means of treatment, due to the vast array of health benefits they provide. The positive outcomes and the strong faith in the power of the mushroom liquid extract, has gained them the title ”\u003cstrong\u003e\u003cem\u003eelixirs of life\u003c\/em\u003e\u003c\/strong\u003e”. These beneficial mushrooms have mainly been used in Asia \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e, but are now spreading to all corners of the world, and are being named \u003cstrong\u003e\u003cem\u003efunctional mushrooms.\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdetails\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eFunctional mushrooms are considered a superfood and are now commonly used as dietary supplements \u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09168451.2018.1431519?journalCode=tbbb20\" target=\"_blank\" title=\"Biologically functional molecules from mushroom-forming fungi. \" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003eToday, we are discovering more and more about the benefits of using these mushrooms and extensive research is being undertaken to understand the bioactive compounds within the mushrooms that provide them with such power.\u003c\/p\u003e\n\u003cp\u003e By using Life Cykel’s mushroom liquid extract, as a supplement in your everyday diet, you can effortlessly give your body and mind the proper support it requires on your mission of health and wellness.\u003c\/p\u003e\n\u003cp\u003e Life Cykel's liquid \u003cstrong\u003e\u003cem\u003edouble\u003c\/em\u003e\u003c\/strong\u003e extracts have been carefully created to be some of the most potent mushroom extracts in the world. Our extract range includes Reishi, Cordyceps, Shiitake, Lion's Mane and Turkey Tail mushrooms.\u003c\/p\u003e\n\u003cp\u003eNot only do we provide you with the best mushroom liquid extract, when producing our extracts we aim to integrate Circular Economy principles wherever possible and where available we're using Australian native mushroom strains that have been meticulously infused with Australian native, wild harvested Kakadu Plum.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/lions-mane-mushroom-liquid-extract\" title=\"Buy Lion's Mane Liquid Extract\"\u003eLion’s Mane Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eLion's Mane Mushroom is known for its positive effects on cognitive health \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24266378\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" rel=\"noopener noreferrer\"\u003e[3]\u003c\/a\u003e. This mushroom is rich in bioactive components \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26244378\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" rel=\"noopener noreferrer\"\u003e[5]\u003c\/a\u003e, which could be responsible for some important physiological activities, this includes antioxidant and anti- inflammatory activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26559695\" title=\"The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\"\u003e [6\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906890\/\" target=\"_blank\" title=\"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities\" rel=\"noopener noreferrer\"\u003e7]\u003c\/a\u003e and neural growth \u003ca href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jnatprod.6b00371?src=recsys\" target=\"_blank\" title=\"Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e, improving memory and focus as well as enhancing your dreams and mood \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31118969\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?\" rel=\"noopener noreferrer\"\u003e[8]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/cordyceps-mushroom-liquid-extract\" title=\"Buy Cordyceps Liquid Extract\"\u003eCordyceps Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eCordyceps mushroom is an extraordinary mushroom. The bioactive compounds within the mushroom, show to promote anti-inflammatory, anti-microbial and anti-oxidative activities (anti-ageing) [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=86265\" target=\"_blank\" title=\"The Effect of the Hot Water Extracts of the Paecilomyces hepiali and Cordyceps militaris Mycelia on the Growth of Gastrointestinal Bacteria\" rel=\"noopener noreferrer\"\u003e10]\u003c\/a\u003e, as well as having beneficial effects on lipid metabolism [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24231073\" target=\"_blank\" title=\"Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice.\" rel=\"noopener noreferrer\"\u003e11]\u003c\/a\u003e and may improve your endurance to prolonged and high intensity exercise \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e[9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5236007\/\" target=\"_blank\" title=\"Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation\" rel=\"noopener noreferrer\"\u003e12\u003c\/a\u003e,\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28094746\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming.\" rel=\"noopener noreferrer\"\u003e13\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/reishi-mushroom-liquid-extract\" title=\"Buy Reishi Liquid Extract\"\u003eReishi Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eFor many millennia the Reishi mushroom has been used to treat a variety of diseases, including cardiovascular diseases and insomnia \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e[14]\u003c\/a\u003e. The constituents within the mushroom may help to enhance anti-microbial, anti-oxidant and immunomodulating activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e [14\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ingentaconnect.com\/contentone\/ben\/cpb\/2016\/00000017\/00000003\/art00010\" target=\"_blank\" title=\"Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents\" rel=\"noopener noreferrer\"\u003e15\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24386913\" target=\"_blank\" title=\"Concentration variation and molecular characteristics of soluble (1,3;1,6)-β-D-glucans in submerged cultivation products of Ganoderma lucidum mycelium\" rel=\"noopener noreferrer\"\u003e16\u003c\/a\u003e]. The mushroom is also well known for its beneficial effects on sleep and relaxation [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e17\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Extract+of+Ganoderma+lucidum+prolongs+sleep+time+in+rats\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats\" rel=\"noopener noreferrer\"\u003e18\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/turkey-tail-mushroom-liquid-extract\" title=\"Buy Turkey Tail Liquid Extract\"\u003eTurkey Tail Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eThe Turkey Tail mushroom is mainly consumed to regulate the immune system. However, more recent research is also showing evidence that the mushroom may have the ability of modulating the composition of the human microbiome [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25006989\" target=\"_blank\" title=\"Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial\" rel=\"noopener noreferrer\"\u003e19\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23435630\" target=\"_blank\" title=\"Trametes versicolor extract modifies human fecal microbiota composition in vitro.\" rel=\"noopener noreferrer\"\u003e20]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/shiitake-mushroom-liquid-extract\" title=\"Buy Shiitake Liquid Extract\"\u003eShiitake mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eShiitake mushrooms have been utilised for their anti-sclerotic (reduce hardening of arteries) activities as well as helping to reduce damage from UV light and helping to increase the renewal process of the skin, therefore this mushroom could be considered as an effective anti-photoaging and skin care ingredient \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\"L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e[21,\u003c\/a\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\"l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study\" rel=\"noopener noreferrer\"\u003e 22,\u003c\/a\u003e \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e23]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eLearn more about our mushrooms by browsing our range of liquid mushroom extracts below or click \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003ehere\u003c\/u\u003e\u003c\/a\u003e to read our latest blogs on these fantastic fungi!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2] Choi, J.-H. (2018). Biologically functional molecules from mushroom-forming fungi. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eBioscience, Biotechnology, and Biochemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 82(3), pp.372–382.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [8] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eExperimental and Therapeutic Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 12(1), pp.513–517.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[9] Das, S.K., Masuda, M., Sakurai, A. and Sakakibara, M. (2010). Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eFitoterapia\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 81(8), pp.961–968.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[10] Ko and Leung. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[11] Gamage, S., Nakayama, J., Fuyuno, Y. and Ohga, S. (2018). The Effect of the Hot Water Extracts of the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePaecilomyces hepiali \u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003eand \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCordyceps militaris\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e Mycelia on the Growth of Gastrointestinal Bacteria. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdvances in Microbiology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 08(07), pp.490–505.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[12] Kim, S.B., Ahn, B., Kim, M., Ji, H.-J., Shin, S.-K., Hong, I.P., Kim, C.Y., Hwang, B.Y. and Lee, M.K. (2014). Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 151(1), pp.478–484.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [13] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[14] Cilerdzic, J., Stajic, M. and Vukojevic, J. (2016). Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCurrent Pharmaceutical Biotechnology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(3), pp.275–282.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[15] Wang, C.-H., Hsieh, S.-C., Wang, H.-J., Chen, M.-L., Lin, B.-F., Chiang, B.-H. and Lu, T.-J. (2014). Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 62(3), pp.634–641.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[16] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[17] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[18] Pallav, K., Dowd, S.E., Villafuerte, J., Yang, X., Kabbani, T., Hansen, J., Dennis, M., Leffler, D.A., Newburg, D.S. and Kelly, C.P. (2014). Effects of polysaccharopeptide fromTrametes Versicolorand amoxicillin on the gut microbiome of healthy volunteers. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eGut Microbes\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 5(4), pp.458–467.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[19] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePlant Foods for Human Nutrition\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 68(2), pp.107–112\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[20] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eNachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[21] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[22] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T22:45:41+11:00","sort_order":"best-selling","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-03T21:01:43+10:00","alt":"","width":2657,"height":2657,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/Reishi_Liquid_Extract.jpg?v=1561725306"}},{"id":81919148101,"handle":"our-most-popular-products","title":"Our most popular products","updated_at":"2019-11-18T23:35:01+11:00","body_html":"","published_at":"2018-10-09T20:31:53+11:00","sort_order":"manual","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-09T21:38:37+11:00","alt":"","width":1000,"height":1061,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/mushroom-box-grown_9f7cd2ae-9917-4975-be1f-7e05481b2d9d.jpg?v=1539081517"}}]$34.95 AUD
Reishi Mushroom Liquid Extract
{"id":1661912842309,"title":"Reishi Mushroom Liquid Extract","handle":"reishi-mushroom-liquid-extract","description":"\u003ch1\u003eThe Mushroom of Immortality\u003c\/h1\u003e\n\u003cp\u003eThe Reishi mushroom is a red woody fungus that tends to grow predominantly on hardwoods. The mushroom is commonly known as the mushroom of immortality, as it has been used for many millennia in Chinese medicine to various diseases such as cardiovascular diseases and insomnia [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e, \u003ca href=\"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.6b00973\" target=\"_blank\" title=\"Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids\" rel=\"noopener noreferrer\"\u003e2]\u003c\/a\u003e. In China the Reishi mushroom is regarded as a symbol of health, longevity, success and divine power [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch2\u003eThe Use of Reishi Liquid Extract\u003c\/h2\u003e\n\u003cp\u003eUnlike some of the Reishi mushroom’s counterparts such as Lion’s mane or Shiitake mushroom, it is not famous for its edibility and taste but rather its pharmaceutical properties [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e]. That is why it is commonly taken as a liquid extract.\u003c\/p\u003e\n\u003cp\u003eThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today. As is the effortless way of incorporating these mushroom extracts into your day to day life. This Reishi mushroom liquid extract makes the bioactive compounds within the mushroom readily available to you, so you can take it easy.\u003c\/p\u003e\n\u003ch3\u003eThe Benefits of Reishi Mushroom\u003c\/h3\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eThe bioactive constituents that have been found to hold medicinal properties within the Reishi mushroom are mainly Lanostane-type triterpinoids and polysaccharides such as beta-glucans. These are considered as potent agents for enhancing the immune system, as well as having high antioxidant and anti-microbial capacities [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e, \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,5d7e3270003d02bf,6a2db231456631ee.html\" target=\"_blank\" title=\"Antibacterial and Antiviral Value of the Genus Ganoderma P. Karst. Species (Aphyllophoromycetideae): A Review\" rel=\"noopener noreferrer\"\u003e3\u003c\/a\u003e].\u003c\/p\u003e\n\u003cp\u003eThe mushroom is also well known for its beneficial effects on sleep and relaxation. When consumed, the mushroom shows to have hypnotic\/sedative type effects, which can decrease sleep latency (time taken to fall asleep) and may increase overall sleeping time, which explains why the mushroom has also been used to treat restlessness, palpitation and insomnia in China for hundreds of years [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e4\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22207209\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats.\" rel=\"noopener noreferrer\"\u003e5]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eTo delve deeper into the world of fungi and to learn more about Reishi mushroom and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003elink \u003c\/u\u003e\u003c\/a\u003eto read our latest blogs . . . . . .\u003c\/p\u003e\n\u003ch4\u003eYour Reishi Liquid Double Extract\u003c\/h4\u003e\n\u003cp\u003eConsumption of Reishi mushroom is increasing all over the world, as many people want to tap into the benefits of this all giving mushroom. That’s why Life Cykel are bringing to you our Reishi mushroom liquid extract so you can relax with Reishi.\u003c\/p\u003e\n\u003cp\u003eAre you interested to buy Reishi Mushroom extract? Then go no further, buy Reishi mushroom liquid extract here, one of Australia’s most unique products!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSome of our customers include: chillers, relaxers, deep breathers, meditators, yoga and Pilates practitioners, mystics, bohemians, surfers, channelers, people in flow, gardeners, kind people, missionaries and musicians.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCustomer Feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e“I travel to the city a lot and always take my Reishi with me. It adds a sense of calmness to my life when immersed in a modern busy lifestyle. It helps me manage stress.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Emma, Nurse, Byron Bay\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add Reishi liquid double extract directly to your coffee, smoothie, tea, soup broth or water in the evening for best results.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml \u003c\/p\u003e\n\u003cp\u003eLife Cykel’s Reishi mushroom liquid extracts are engineered in the Northern Rivers, NSW.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle \u003cspan\u003e(60 day supply\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003eOriginally harvested in the USA\u003c\/li\u003e\n\u003cli\u003eAustralian sourced ingredients\u003c\/li\u003e\n\u003cli\u003eGluten free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e:\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eDistilled Water, Organic Alcohol,\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eGanoderma lucidium.\u003c\/em\u003e \u003c\/span\u003e\u003cspan\u003e(\u003c\/span\u003e\u003cspan\u003eG\u003cem\u003eanoderma lucidium.\u003c\/em\u003e\u003c\/span\u003e\u003cspan\u003e Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eGanoderma lucidium.\u003c\/em\u003e\u003c\/span\u003e\u003cspan\u003e Fruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eStorage\u003cstrong\u003e: \u003c\/strong\u003e\u003c\/b\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cspan style=\"font-weight: 400;\"\u003eReferences\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Sissi WG, John Y, John AB, Iris FFB. Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Herbal Medicine: Biomolecular and Clinical\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [2] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Wachtel-Galor S, Yuen J, Buswell JA, et al. (2011) Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press\/Taylor \u0026amp; Francis; 2011. Chapter 9.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Gao, Y; Zhou, S; Huang, M; Xu, A (2013). Antibacterial and antiviral value of the genus Ganoderma P. Karst. species (aphyllophoromycetideae): A review. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, [online] 5(3), pp.235–246. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[8] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003col start=\"2\"\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e* This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e* This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T21:45:52+11:00","created_at":"2018-10-03T20:23:12+10:00","vendor":"Life Cykel","type":"","tags":[],"price":3495,"price_min":3495,"price_max":5295,"available":true,"price_varies":true,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":31070766268476,"title":"120ml","option1":"120ml","option2":null,"option3":null,"sku":"RDE120ml-1","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Reishi Mushroom Liquid Extract - 120ml","public_title":"120ml","options":["120ml"],"price":5295,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"705632689127"},{"id":31070774263868,"title":"60ml","option1":"60ml","option2":null,"option3":null,"sku":"RDE60ml","requires_shipping":true,"taxable":true,"featured_image":{"id":13341065642044,"product_id":1661912842309,"position":3,"created_at":"2019-10-31T15:10:58+11:00","updated_at":"2019-10-31T15:10:58+11:00","alt":null,"width":1033,"height":1500,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.reishi.60ml.png?v=1572495058","variant_ids":[31070774263868]},"available":true,"name":"Reishi Mushroom Liquid Extract - 60ml","public_title":"60ml","options":["60ml"],"price":3495,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"0793591711201"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Reishi_Extract_cfa122b4-be2c-45b8-b1ce-581e7cab0edc.jpg?v=1564227663","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Reishi_s.jpg?v=1564227663","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.reishi.60ml.png?v=1572495058"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Reishi_Extract_cfa122b4-be2c-45b8-b1ce-581e7cab0edc.jpg?v=1564227663","options":["Size"],"content":"\u003ch1\u003eThe Mushroom of Immortality\u003c\/h1\u003e\n\u003cp\u003eThe Reishi mushroom is a red woody fungus that tends to grow predominantly on hardwoods. The mushroom is commonly known as the mushroom of immortality, as it has been used for many millennia in Chinese medicine to various diseases such as cardiovascular diseases and insomnia [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e, \u003ca href=\"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.6b00973\" target=\"_blank\" title=\"Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids\" rel=\"noopener noreferrer\"\u003e2]\u003c\/a\u003e. In China the Reishi mushroom is regarded as a symbol of health, longevity, success and divine power [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch2\u003eThe Use of Reishi Liquid Extract\u003c\/h2\u003e\n\u003cp\u003eUnlike some of the Reishi mushroom’s counterparts such as Lion’s mane or Shiitake mushroom, it is not famous for its edibility and taste but rather its pharmaceutical properties [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e]. That is why it is commonly taken as a liquid extract.\u003c\/p\u003e\n\u003cp\u003eThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today. As is the effortless way of incorporating these mushroom extracts into your day to day life. This Reishi mushroom liquid extract makes the bioactive compounds within the mushroom readily available to you, so you can take it easy.\u003c\/p\u003e\n\u003ch3\u003eThe Benefits of Reishi Mushroom\u003c\/h3\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eThe bioactive constituents that have been found to hold medicinal properties within the Reishi mushroom are mainly Lanostane-type triterpinoids and polysaccharides such as beta-glucans. These are considered as potent agents for enhancing the immune system, as well as having high antioxidant and anti-microbial capacities [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e, \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,5d7e3270003d02bf,6a2db231456631ee.html\" target=\"_blank\" title=\"Antibacterial and Antiviral Value of the Genus Ganoderma P. Karst. Species (Aphyllophoromycetideae): A Review\" rel=\"noopener noreferrer\"\u003e3\u003c\/a\u003e].\u003c\/p\u003e\n\u003cp\u003eThe mushroom is also well known for its beneficial effects on sleep and relaxation. When consumed, the mushroom shows to have hypnotic\/sedative type effects, which can decrease sleep latency (time taken to fall asleep) and may increase overall sleeping time, which explains why the mushroom has also been used to treat restlessness, palpitation and insomnia in China for hundreds of years [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e4\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22207209\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats.\" rel=\"noopener noreferrer\"\u003e5]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eTo delve deeper into the world of fungi and to learn more about Reishi mushroom and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003elink \u003c\/u\u003e\u003c\/a\u003eto read our latest blogs . . . . . .\u003c\/p\u003e\n\u003ch4\u003eYour Reishi Liquid Double Extract\u003c\/h4\u003e\n\u003cp\u003eConsumption of Reishi mushroom is increasing all over the world, as many people want to tap into the benefits of this all giving mushroom. That’s why Life Cykel are bringing to you our Reishi mushroom liquid extract so you can relax with Reishi.\u003c\/p\u003e\n\u003cp\u003eAre you interested to buy Reishi Mushroom extract? Then go no further, buy Reishi mushroom liquid extract here, one of Australia’s most unique products!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSome of our customers include: chillers, relaxers, deep breathers, meditators, yoga and Pilates practitioners, mystics, bohemians, surfers, channelers, people in flow, gardeners, kind people, missionaries and musicians.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCustomer Feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e“I travel to the city a lot and always take my Reishi with me. It adds a sense of calmness to my life when immersed in a modern busy lifestyle. It helps me manage stress.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Emma, Nurse, Byron Bay\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add Reishi liquid double extract directly to your coffee, smoothie, tea, soup broth or water in the evening for best results.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml \u003c\/p\u003e\n\u003cp\u003eLife Cykel’s Reishi mushroom liquid extracts are engineered in the Northern Rivers, NSW.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle \u003cspan\u003e(60 day supply\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003eOriginally harvested in the USA\u003c\/li\u003e\n\u003cli\u003eAustralian sourced ingredients\u003c\/li\u003e\n\u003cli\u003eGluten free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e:\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eDistilled Water, Organic Alcohol,\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eGanoderma lucidium.\u003c\/em\u003e \u003c\/span\u003e\u003cspan\u003e(\u003c\/span\u003e\u003cspan\u003eG\u003cem\u003eanoderma lucidium.\u003c\/em\u003e\u003c\/span\u003e\u003cspan\u003e Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eGanoderma lucidium.\u003c\/em\u003e\u003c\/span\u003e\u003cspan\u003e Fruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eStorage\u003cstrong\u003e: \u003c\/strong\u003e\u003c\/b\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cspan style=\"font-weight: 400;\"\u003eReferences\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Sissi WG, John Y, John AB, Iris FFB. Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Herbal Medicine: Biomolecular and Clinical\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [2] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Wachtel-Galor S, Yuen J, Buswell JA, et al. (2011) Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press\/Taylor \u0026amp; Francis; 2011. Chapter 9.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Gao, Y; Zhou, S; Huang, M; Xu, A (2013). Antibacterial and antiviral value of the genus Ganoderma P. Karst. species (aphyllophoromycetideae): A review. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, [online] 5(3), pp.235–246. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[8] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003col start=\"2\"\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e* This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e* This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/details\u003e"} [{"id":92048490565,"handle":"all","title":"All","updated_at":"2019-11-18T23:35:01+11:00","body_html":"","published_at":"2019-02-18T10:20:43+11:00","sort_order":"best-selling","template_suffix":"","disjunctive":false,"rules":[{"column":"variant_price","relation":"greater_than","condition":"0"},{"column":"variant_inventory","relation":"greater_than","condition":"0"},{"column":"type","relation":"not_equals","condition":"Insurance"}],"published_scope":"web"},{"id":80859955269,"handle":"liquid-extracts","title":"Liquid Mushroom Extract - The Elixir of Life","updated_at":"2019-11-18T23:35:01+11:00","body_html":"\u003cp\u003eGive your body and mind proper support on your journey to vitality and longevity. Find the best organic liquid Mushroom extracts at Life Cykel today!\u003c\/p\u003e\n\u003cp\u003eFor thousands of years, traditional medicine has used mushroom tinctures as a primary means of treatment, due to the vast array of health benefits they provide. The positive outcomes and the strong faith in the power of the mushroom liquid extract, has gained them the title ”\u003cstrong\u003e\u003cem\u003eelixirs of life\u003c\/em\u003e\u003c\/strong\u003e”. These beneficial mushrooms have mainly been used in Asia \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e, but are now spreading to all corners of the world, and are being named \u003cstrong\u003e\u003cem\u003efunctional mushrooms.\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdetails\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eFunctional mushrooms are considered a superfood and are now commonly used as dietary supplements \u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09168451.2018.1431519?journalCode=tbbb20\" target=\"_blank\" title=\"Biologically functional molecules from mushroom-forming fungi. \" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003eToday, we are discovering more and more about the benefits of using these mushrooms and extensive research is being undertaken to understand the bioactive compounds within the mushrooms that provide them with such power.\u003c\/p\u003e\n\u003cp\u003e By using Life Cykel’s mushroom liquid extract, as a supplement in your everyday diet, you can effortlessly give your body and mind the proper support it requires on your mission of health and wellness.\u003c\/p\u003e\n\u003cp\u003e Life Cykel's liquid \u003cstrong\u003e\u003cem\u003edouble\u003c\/em\u003e\u003c\/strong\u003e extracts have been carefully created to be some of the most potent mushroom extracts in the world. Our extract range includes Reishi, Cordyceps, Shiitake, Lion's Mane and Turkey Tail mushrooms.\u003c\/p\u003e\n\u003cp\u003eNot only do we provide you with the best mushroom liquid extract, when producing our extracts we aim to integrate Circular Economy principles wherever possible and where available we're using Australian native mushroom strains that have been meticulously infused with Australian native, wild harvested Kakadu Plum.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/lions-mane-mushroom-liquid-extract\" title=\"Buy Lion's Mane Liquid Extract\"\u003eLion’s Mane Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eLion's Mane Mushroom is known for its positive effects on cognitive health \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24266378\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" rel=\"noopener noreferrer\"\u003e[3]\u003c\/a\u003e. This mushroom is rich in bioactive components \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26244378\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" rel=\"noopener noreferrer\"\u003e[5]\u003c\/a\u003e, which could be responsible for some important physiological activities, this includes antioxidant and anti- inflammatory activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26559695\" title=\"The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\"\u003e [6\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906890\/\" target=\"_blank\" title=\"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities\" rel=\"noopener noreferrer\"\u003e7]\u003c\/a\u003e and neural growth \u003ca href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jnatprod.6b00371?src=recsys\" target=\"_blank\" title=\"Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e, improving memory and focus as well as enhancing your dreams and mood \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31118969\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?\" rel=\"noopener noreferrer\"\u003e[8]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/cordyceps-mushroom-liquid-extract\" title=\"Buy Cordyceps Liquid Extract\"\u003eCordyceps Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eCordyceps mushroom is an extraordinary mushroom. The bioactive compounds within the mushroom, show to promote anti-inflammatory, anti-microbial and anti-oxidative activities (anti-ageing) [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=86265\" target=\"_blank\" title=\"The Effect of the Hot Water Extracts of the Paecilomyces hepiali and Cordyceps militaris Mycelia on the Growth of Gastrointestinal Bacteria\" rel=\"noopener noreferrer\"\u003e10]\u003c\/a\u003e, as well as having beneficial effects on lipid metabolism [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24231073\" target=\"_blank\" title=\"Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice.\" rel=\"noopener noreferrer\"\u003e11]\u003c\/a\u003e and may improve your endurance to prolonged and high intensity exercise \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e[9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5236007\/\" target=\"_blank\" title=\"Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation\" rel=\"noopener noreferrer\"\u003e12\u003c\/a\u003e,\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28094746\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming.\" rel=\"noopener noreferrer\"\u003e13\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/reishi-mushroom-liquid-extract\" title=\"Buy Reishi Liquid Extract\"\u003eReishi Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eFor many millennia the Reishi mushroom has been used to treat a variety of diseases, including cardiovascular diseases and insomnia \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e[14]\u003c\/a\u003e. The constituents within the mushroom may help to enhance anti-microbial, anti-oxidant and immunomodulating activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e [14\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ingentaconnect.com\/contentone\/ben\/cpb\/2016\/00000017\/00000003\/art00010\" target=\"_blank\" title=\"Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents\" rel=\"noopener noreferrer\"\u003e15\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24386913\" target=\"_blank\" title=\"Concentration variation and molecular characteristics of soluble (1,3;1,6)-β-D-glucans in submerged cultivation products of Ganoderma lucidum mycelium\" rel=\"noopener noreferrer\"\u003e16\u003c\/a\u003e]. The mushroom is also well known for its beneficial effects on sleep and relaxation [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e17\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Extract+of+Ganoderma+lucidum+prolongs+sleep+time+in+rats\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats\" rel=\"noopener noreferrer\"\u003e18\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/turkey-tail-mushroom-liquid-extract\" title=\"Buy Turkey Tail Liquid Extract\"\u003eTurkey Tail Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eThe Turkey Tail mushroom is mainly consumed to regulate the immune system. However, more recent research is also showing evidence that the mushroom may have the ability of modulating the composition of the human microbiome [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25006989\" target=\"_blank\" title=\"Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial\" rel=\"noopener noreferrer\"\u003e19\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23435630\" target=\"_blank\" title=\"Trametes versicolor extract modifies human fecal microbiota composition in vitro.\" rel=\"noopener noreferrer\"\u003e20]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/shiitake-mushroom-liquid-extract\" title=\"Buy Shiitake Liquid Extract\"\u003eShiitake mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eShiitake mushrooms have been utilised for their anti-sclerotic (reduce hardening of arteries) activities as well as helping to reduce damage from UV light and helping to increase the renewal process of the skin, therefore this mushroom could be considered as an effective anti-photoaging and skin care ingredient \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\"L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e[21,\u003c\/a\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\"l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study\" rel=\"noopener noreferrer\"\u003e 22,\u003c\/a\u003e \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e23]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eLearn more about our mushrooms by browsing our range of liquid mushroom extracts below or click \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003ehere\u003c\/u\u003e\u003c\/a\u003e to read our latest blogs on these fantastic fungi!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2] Choi, J.-H. (2018). Biologically functional molecules from mushroom-forming fungi. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eBioscience, Biotechnology, and Biochemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 82(3), pp.372–382.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [8] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eExperimental and Therapeutic Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 12(1), pp.513–517.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[9] Das, S.K., Masuda, M., Sakurai, A. and Sakakibara, M. (2010). Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eFitoterapia\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 81(8), pp.961–968.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[10] Ko and Leung. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[11] Gamage, S., Nakayama, J., Fuyuno, Y. and Ohga, S. (2018). The Effect of the Hot Water Extracts of the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePaecilomyces hepiali \u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003eand \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCordyceps militaris\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e Mycelia on the Growth of Gastrointestinal Bacteria. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdvances in Microbiology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 08(07), pp.490–505.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[12] Kim, S.B., Ahn, B., Kim, M., Ji, H.-J., Shin, S.-K., Hong, I.P., Kim, C.Y., Hwang, B.Y. and Lee, M.K. (2014). Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 151(1), pp.478–484.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [13] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[14] Cilerdzic, J., Stajic, M. and Vukojevic, J. (2016). Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCurrent Pharmaceutical Biotechnology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(3), pp.275–282.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[15] Wang, C.-H., Hsieh, S.-C., Wang, H.-J., Chen, M.-L., Lin, B.-F., Chiang, B.-H. and Lu, T.-J. (2014). Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 62(3), pp.634–641.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[16] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[17] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[18] Pallav, K., Dowd, S.E., Villafuerte, J., Yang, X., Kabbani, T., Hansen, J., Dennis, M., Leffler, D.A., Newburg, D.S. and Kelly, C.P. (2014). Effects of polysaccharopeptide fromTrametes Versicolorand amoxicillin on the gut microbiome of healthy volunteers. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eGut Microbes\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 5(4), pp.458–467.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[19] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePlant Foods for Human Nutrition\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 68(2), pp.107–112\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[20] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eNachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[21] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[22] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T22:45:41+11:00","sort_order":"best-selling","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-03T21:01:43+10:00","alt":"","width":2657,"height":2657,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/Reishi_Liquid_Extract.jpg?v=1561725306"}},{"id":81919148101,"handle":"our-most-popular-products","title":"Our most popular products","updated_at":"2019-11-18T23:35:01+11:00","body_html":"","published_at":"2018-10-09T20:31:53+11:00","sort_order":"manual","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-09T21:38:37+11:00","alt":"","width":1000,"height":1061,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/mushroom-box-grown_9f7cd2ae-9917-4975-be1f-7e05481b2d9d.jpg?v=1539081517"}}]$34.95 AUD
Shiitake Mushroom Liquid Extract
{"id":1662038736965,"title":"Shiitake Mushroom Liquid Extract","handle":"shiitake-mushroom-liquid-extract","description":"\u003ch2\u003e\u003cstrong\u003eHOLY SHIITAKE\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eConnect to your inner radiance with Life Cykel’s Shiitake Mushroom Extract.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Shiitake mushroom is ranked number 2 in the global mushroom market, for its delicious taste as well as its array of health and beauty benefits \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"entinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e. This mushroom has been utilised as an edible and medicinal mushroom in Asia for many years thanks to its immune regulating and anti-ageing actions \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21598414\" target=\"_blank\" title=\"Efficacy and safety of orally administered Lentinula edodes mycelia extract for patients undergoing cancer chemotherapy: a pilot study.\" rel=\"noopener noreferrer\"\u003e[2].\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eThe Benefits of Shiitake Mushroom\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eThere are many bioactive compounds within the Shiitake mushroom, including the polysaccharide, lentinan, which is shown to increase the activity of the immune system \u003ca href=\"https:\/\/nutritionj.biomedcentral.com\/articles\/10.1186\/1475-2891-13-35\" target=\"_blank\" title=\"Dietary supplementation with rice bran fermented with Lentinus edodesincreases interferon-γ activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study\" rel=\"noopener noreferrer\"\u003e[3].\u003c\/a\u003e Further, beta-gluans and ergosterols found within the mushroom have also been seen to prevent sclerosis (the hardening of arteries), which in turn may support a healthy cardiovascular system \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"entinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e The Shiitake mushroom also works wonders for our skin and hair. The mushroom contains large quantities of the amino acid l-Ergothioneine, which helps to reduce damage from UV light\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\" Article (PDF Available) · March 2014 with 142 Reads DOI: 10.3390\/cosmetics1010051 Cite this publication Karolina Bazela 24.13Dr. Irena Eris Aleksandra Solyga-Zurek + 2 Renata Monika Debowska 23.08Independent Researcher Katarzyna Rogiewicz Show more authors Abstract Many changes related to aging at the cellular level may be due to the physiological condition of mitochondria. One of the most common types of damage of mtDNA is the so-called “common deletion” referring to a deletion of 4977 base pairs. In the skin cells this phenomenon probably is caused by oxidative damage of mtDNA induced by UV. The present study was aimed at evaluating the effect of the antioxidant l-ergothioneine on UV-induced damage in skin cells. The effect of l-ergothioneine on the reduced glutathione level was studied. The presence of the “common deletion” in human fibroblasts irradiated with UVA and treated with l-ergothioneine was evaluated by a polymerase chain reaction. We have demonstrated that l-ergothioneine enhanced the level of reduced glutathione and protected cells from the induction of a photoaging-associated mtDNA “common deletion”. In view of our results, l-ergothioneine could be an effective skin care and anti-photoaging ingredient. Discover the world's research 15+ million members 118+ million publications 700k+ research projects Join for free Figures - available via license: CC BY 4.0 Content may be subject to copyright. Chemical structure of L-ergothioneine. Chemical structure of L-ergothioneine. … . PCR primers for detection of the \u0026quot;common deletion\u0026quot; in mtDNA. . PCR primers for detection of the \u0026quot;common deletion\u0026quot; in mtDNA. … . . … +1 No caption available … Available via license: CC BY 4.0 Content may be subject to copyright. Download full-text PDF Cosmetics 2014, 1, 51-60; doi:10.3390\/cosmetics1010051 cosmetics ISSN 2079-9284 www.mdpi.com\/journal\/cosmetics Communication L-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study Karolina Bazela 1,†,*, Aleksandra Solyga-Zurek 2,†, Renata Debowska 1, Katarzyna Rogiewicz 1, Ewa Bartnik 2 and Irena Eris 1 1 Dr. Irena Eris Cosmetic Laboratories, Centre for Science and Research, Pulawska 107a, Warsaw 02-595, Poland; E-Mails: renata.debowska@eris.pl (R.D.); katarzyna.rogiewicz@eris.pl (K.R.); irena.eris@eris.pl (I.E.) 2 Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, Warsaw 02-106, Poland; E-Mails: asolyga@biol.uw.edu.pl (A.S.-Z.); ebartnik@igib.uw.edu.pl (E.B.) † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: karolina.bazela@eris.pl; Tel.: +48-22-717-1248; Fax: +48-22-757-0612. Received: 31 December 2013; in revised form: 10 March 2014 \/ Accepted: 11 March 2014 \/ Published: 20 March 2014 Abstract: Many changes related to aging at the cellular level may be due to the physiological condition of mitochondria. One of the most common types of damage of mtDNA is the so-called “common deletion” referring to a deletion of 4977 base pairs. In the skin cells this phenomenon probably is caused by oxidative damage of mtDNA induced by UV. The present study was aimed at evaluating the effect of the antioxidant L-ergothioneine on UV-induced damage in skin cells. The effect of L-ergothioneine on the reduced glutathione level was studied. The presence of the “common deletion” in human fibroblasts irradiated with UVA and treated with L-ergothioneine was evaluated by a polymerase chain reaction. We have demonstrated that L-ergothioneine enhanced the level of reduced glutathione and protected cells from the induction of a photoaging-associated mtDNA “common deletion”. In view of our results, L-ergothioneine could be an effective skin care and anti-photoaging ingredient. Keywords: L-ergothioneine; common deletion; mitochondria; photoaging OPEN ACCESS Cosmetics 2014, 1 52 1. Introduction Ultraviolet irradiation is one of the most important environmental factors in the development of a number of skin conditions, ranging from photoaging to cancer. UVA\/B rays penetrate into the skin, reach cells and are absorbed by proteins, lipids, and nuclear and mitochondrial DNA, causing a cascade of oxidative events that can result in progressive deterioration of cellular structure and function [1–3]. There are many theories of aging and a number of them encompass the role of mitochondria in this process. Mitochondria are responsible for producing approximately 90% of the cellular energy in the process of oxidative phosphorylation where electrons from NADH and FADH2 are transferred to oxygen. This generates a significant amount of reactive oxygen species (ROS). Mitochondria are able to counteract the production of ROS with antioxidant defense systems which can detoxify the amount of ROS produced, however, some ROS do evade these processes and are able to damage mitochondrial DNA (mtDNA) as well as proteins and lipids. Mitochondria contain their own DNA (mtDNA), which is distinct from nuclear DNA and more susceptible to damage. Mitochondrial DNA mutations and deletions have been shown to accumulate in many tissues in mammals during aging. mtDNA mutations are thought to arise due to the close proximity to the inner membrane where reactive oxygen species are continually produced in the electron transport chain. This, along with the absence of protective histones and impaired DNA photoproduct repair makes mtDNA a sensitive marker of UV-induced DNA damage [4,5]. It has been shown that photoaged skin is characterized by increased mutations in the mitochondrial (mt) genome [6]. The most frequently reported deletion is a large-scale (4977 bp) deletion also called the “common deletion” (CD). In human skin CD has been shown to occur more frequently with increasing sun exposure and thus appears to be a useful marker rather for UVA induced alterations than for chronological aging [7–10]. The use of antioxidants is an effective approach to prevent symptoms related to photo-induced aging of the skin. Many antioxidants have long been used in cosmetology. L-Ergothioneine (EGT) is an unusual sulphur-containing derivative of an amino acid, histidine, which is acquired by mammals exclusively in their diet. L-Ergothioneine has two functional groups: L-thiol (SH) group and quaternary ammonium group N–(CH3)3 (Figure 1). EGT’s thiol group implies an antioxidant role. The quaternary group EGT resembles carnitine and transfers fatty acids into the mitochondria, therefore increasing the ATP level in cells. EGT is concentrated in cells and tissues frequently exposed to oxidative stress. Numerous in vitro assays have demonstrated the antioxidant and cytoprotective capabilities of EGT against a wide range of cellular stressors [11–13]. Figure 1. Chemical structure of L-ergothioneine. Cosmetics 2014, 1 53 On the basis of these data on the antioxidant activity of L-ergothioneine we found it interesting to study the effect of this substance on UV-induced alterations in skin cell cultures, particularly on mtDNA damage. 2. Experimental Section 2.1. Cell Cultures KB cells (epidermoid carcinoma cell line KB, American Type Culture Collection (ATCC), Manassas, VA, USA) were grown in standard RPMI medium (Invitrogen, Carlsbad, CA, USA), supplemented with 10% fetal calf serum, 2 mM L-glutamine and antibiotics (100 U\/mL penicillin, 0.25 µg\/mL streptomycin sulfate) at 37 °C in 5% CO2. The KB cell line was used as a model representing human keratinocytes. Skin samples, obtained from donors undergoing cosmetic surgery, were treated with dispase II solution (5 mg\/mL, Sigma-Aldrich, St. Louis, MO, USA) at 4 °C for 16 h, followed by separation of dermal and epidermal layers with tweezers. Next, the dermis was cut into ~1 mm2 fragments and treated with 2 mg\/mL collagenase and 0.1 mg\/mL DNase (Sigma-Aldrich, St. Louis, MO, USA) overnight. Liberated cells were seeded into cell culture flasks for culture. Primary human fibroblasts were grown in standard DMEM medium (Invitrogen, Carlsbad, CA, USA), supplemented with 10% fetal calf serum (Invitrogen, Carlsbad, CA, USA), 10 mM HEPES, 2 mM L-glutamine and antibiotics (100 U\/mL penicillin, 0.25 µg\/mL streptomycin sulfate) and 50 µg\/mL uridine, with or without 20 µM L-ergothioneine (Barnet Products Corp.,Englewood Cliffs, NJ, USA), at 37 °C in 5% CO2. Confluent passages between 2 and 8 were used. 2.2. UVB Irradiation Confluent KB cells (control and treated with 20 µM L-ergothioneine (Barnet Products Corp., Englewood Cliffs, NJ, USA)) were exposed to UVB (300 J\/m2, fluorescent bulb TL12 Philips, emission peak at 313 nm) through phosphate buffered saline. 2.3. UVA Irradiation The presence of the “common deletion” was evaluated in fibroblasts derived from 2 female donors aged 38 and 45 and from 2 male donors aged 30 and 42. Cells were grown in the presence of 50 µg\/mL uridine (Sigma-Aldrich, St. Louis, MO, USA), with or without 20 µM L-ergothioneine and irradiated with 3 doses (8 J\/cm2, fluorescent bulb GE F4T5\/BLB, emission peak at 368 nm) of UVA per day, through phosphate buffered saline. This procedure was repeated for 4 consecutive days during 3 weeks. 2.4. Colorimetric Determination of Reduced Glutathione (GSH) GSH level was measured using the GSH\/GSSG-412 assay (OxisResearchTM, Portland, OR, USA)—colorimetric determination of reduced and oxidized glutathione. The method employs Ellmanʼs reagent (5,5'-dithiobis-2-nitrobenzoic acid—DTNB), which reacts with GSH to form a product which is spectrophotometrically detectable at 412 nm. The change in absorbance at 412 nm is Cosmetics 2014, 1 54 a linear function of the GSH concentration in the reaction mixture [14]. The protein concentration was measured with Bradford Reagent (Sigma-Aldrich, St. Louis, MO, USA) [15]. Three independent experiments were performed. Comparisons between control and post-treatment measurements were performed using an unpaired Student’s t-test. Probability values of p \u0026lt; 0.05 were considered statistically significant. 2.5. “Common Deletion” (CD) PCR Phenol-chloroform extraction of total DNA and PCR (Fermentas, Lithuania, Vilnius) were performed according to standard protocols. PCR reaction mixture, for both primer pairs, contained: F primer 2 μM; R primer 2 μM; dNTP 20 mM; Taq Buffer with (NH4)2SO4 and 20 mM MgCl2 1×; Taq polymerase 1 U; DNA 100 ng. All reactions were performed in 25 µL volume in the following conditions: the denaturation step was carried out at 94 C for 3 min, 35 cycles of 94 C for 30 s, 58 C for 30 s, 72 C for 1 min, and a final extension of 72 C for 7 min. See Table 1 for primers used. Table 1. PCR primers for detection of the “common deletion” in mtDNA. PCR primer Orientation Position MT1A F 8224-8247 MT1C F 13176-13198MT2 R 13501-13477PCR reaction with primers MT1A–MT2 was carried out, amplifying a fragment 300 bp in length when the “common deletion” was present. In order to ensure that the absence of CD PCR product is caused by the absence of CD and not by an incorrect PCR reaction, PCR with primers MT1A–MT2 was performed. A corresponding product 325 bp in length is obtained when the mitochondrial genome without the deletion is present and thus serves as a control for the PCR reaction. As a positive control of the PCR reaction, DNA isolated from a patient with a previously confirmed common deletion in mtDNA was used. PCR products were detected by electrophoresis on a 1.5% agarose gel with ethidium bromide against a DNA molecular-weight marker. The gel was photographed under UV transillumination. Three independent experiments were performed. 3. Results and Discussion 3.1. L-Ergothioneine Increases the Reduced Glutathione (GSH) Level The tripeptide glutathione (GSH) is the most abundant intracellular non-protein thiol. It is present predominantly in a reduced form (GSH), which is the biologically active form. Over the years, a great deal of information has been gathered on the role of GSH in maintaining the intracellular reduction–oxidation (redox) environment including antioxidant defense via direct interaction with reactive oxygen\/nitrogen species (ROS\/RNS) or via activities of detoxification enzymes like GSH peroxidases and GSH-S-transferases [16]. In our study we tested the effect of L-ergothioneine on the reduced glutathione (GSH) level in the KB cell line using the GSH\/GSSG-412 colorimetric assay. Our studies showed that L-ergothioneine at the 20 µM concentration (chosen according to our previous studies [17]) increased the reduced glutathione (GSH) level both in control and UVB irradiated Cosmetics 2014, 1 55 KB cells (Table 2). Changes between GSH level in control compared with GSH level after treatment with L-ergothioneine, both in cells exposed and unexposed to UVB, were statistically significant. The UVB light was chosen for the irradiation of KB cells since it is the light of the UVB spectrum that is for the most part absorbed by the epidermis in vivo [18]. UVB may also damage epidermal cells both directly and indirectly by inducing the formation of reactive oxygen species, i.e., the superoxide anion [19]. Thus, it was deemed necessary to study the antioxidative effect of EGT on UVB irradiated epidermis. Table 2. Quantitative determination of glutathione (GSH) level in KB cells. KB cells µmol GSH\/µg protein −UVB +UVB (300 J\/m2) control 6.07 ± 0.15 3.03 ± 0.02 20 µM L-ergothioneine 15.37 ± 0.13 4.65 ± 0.06 Our results are in line with numerous studies demonstrating that L-ergothioneine is an integral component of the cellular antioxidant defense system. It scavenges hydroxyl and peroxynitrite radicals as well as the superoxide anion radical and singlet oxygen. In vitro tests have also demonstrated that EGT also has strong copper chelating ability—it potentially inhibits tyrosinase activity [20–22]. Moreover, in vitro tests have demonstrated that in cultured fibroblasts EGT suppressed the tumor necrosis factor α (TNF α) up-regulation induced by UVB irradiation. In addition in fibroblasts exposed to UVA, EGT suppressed the expression of matrix metalloproteinase 1 (MMP 1) protein [23]. EGT also inhibited nuclear factor kβ (NF kβ) activation and limited the transcriptional activation of the gene for interleukin 8 (IL-8)—a chemotaxin which might account for neutrophil recruitment [24]. It has been demonstrated that EGT is a more powerful antioxidant than either coenzyme Q(10) or idebenone due to its relatively greater efficiency in directly scavenging free radicals and in protecting cells from UV-induced ROS [25]. Recently, a high specific transporter for EGT (ETT) was identified in mammalian tissues, which explains the high tissue levels of EGT and implies a physiological role. Depletion of ETT leads to augmented oxidative stress and cell death. ETT is highly concentrated in the plasma membrane and mitochondria [11]. 3.2. L-Rrgothioneine Shows Protective Properties against the Induction of a Photoaging-Associated mtDNA “Common Deletion” One of the best described mt deletions, the 4977 bp “common deletion”, is known to be involved in photoaging of the skin. Intraindividual comparison studies have revealed that the “common deletion” is increased up to 10-fold in photoaged skin, as compared with sun-protected skin of the same individuals [7]. The objective of our study was to evaluate the effect of L-ergothioneine on the occurrence of mtDNA “common deletion” in UV-irradiated human primary fibroblasts obtained from various donors. For the experiments on dermal cells only UVA irradiation was performed, since the great majority of UVB rays is absorbed by the epidermis and hence never reaches the dermal level [18]. UVA is known to cause mainly indirect damage to cellular structures and nucleic acids by inducing the formation of radical oxygen and nitrogen species but may also be responsible for single- and double-strands breaks in DNA [19]. Thus, exposure to UVA may be one of the main causes Cosmetics 2014, 1 56 of mtDNA mutations including mtDNA deletions [26]. In our experiments, in fibroblasts which were not exposed to UVA we did not observe the “common deletion” after DNA isolation nor during 3 weeks of culture (Figure 2, lanes 9, 11 and 13). When we incubated fibroblasts with L-ergothioneine we also observed no “common deletion” PCR product (Figure 3, lanes 9, 11 and 13). To summarize this part of our study: first of all, cultured fibroblasts isolated from various donors did not initially show the “common deletion”. Secondly, L-ergothioneine, itself, had no influence on the presence of the “common deletion”. Figure 2. Representative PCR analysis of the presence of the “common deletion” in a culture of human fibroblasts incubated with and without UVA exposure, without the presence of L-ergothioneine. M, molecular weight marker; C, control PCR reaction, confirming the presence of mtDNA; 1, fibroblasts after 1 week with UVA exposure; 3, fibroblasts after 2 weeks with UVA exposure; 5, fibroblasts after 3 weeks with UVA exposure; 7, positive control—DNA from a patient with a previously confirmed presence of “common deletion”; 9, fibroblasts after 1 week without UVA exposure; 11, fibroblasts after 2 weeks without UVA exposure; 13 fibroblasts after 3 weeks without UVA exposure. We were able to induce the “common deletion” using repetitive UVA irradiation in cultured human fibroblasts derived from two donors (Figure 2, lanes 1, 3 and 5) suggesting that there is an individual susceptibility to the induction of CD, at least in our in vitro model. Due to the fact that our “common deletion” analysis was performed on fibroblasts isolated from four donors, this requires further studies. When fibroblasts were irradiated and co-incubated with 20 µM L-ergothioneine we did not observe the “common deletion” even after 3 weeks with UVA exposure, suggesting that L-ergothioneine may prevent the formation of this particular damage in mtDNA (Figure 3, lanes 1, 3 and 5). Our results are in accordance with the previous studies where repetitive exposure of keratinocytes, fibroblasts or Cosmetics 2014, 1 57 human skin to UVA at physiological doses was found to induce mutations of mtDNA [7,27–29]. Interestingly, it has been shown that in fibroblasts the level of CD is decreasing with prolonged culture, which can be counteracted with uridine supplementation of culture media [6,7,30]. For this reason, uridine supplementation was employed during all CD analyses in this study. Figure 3. Representative PCR analysis of the presence of the “common deletion” in a culture of human fibroblasts incubated with and without UVA exposure, in the presence of 20 µM L-ergothioneine. M, molecular weight marker; C, control PCR reaction, confirming the presence of mtDNA; 1, fibroblasts after 1 week with UVA exposure; 3, fibroblasts after 2 weeks with UVA exposure; 5, fibroblasts after 3 weeks with UVA exposure; 7, positive control—DNA from a patient with a previously confirmed presence of “common deletion”; 9, fibroblasts after 1 week without UVA exposure; 11, fibroblasts after 2 weeks without UVA exposure; 13, fibroblasts after 3 weeks without UVA exposure. Protection against the induction of a photoaging-associated mtDNA mutation has been also previously shown for two other widely applied cosmetic actives—β-carotene and genistein [31,32]. Our results demonstrated that L-ergothioneine may protect skin cells against some UV-induced damage; in particular against the occurrence of mitDNA “common deletion”. Further studies are required to assess the full-spectrum of L-ergothioneine’s protective activity. We conclude that L-ergothioneine, as an active compound of cosmetic products, shows considerable promise as an effective agent against the aging process. On the other hand, we have shown that in cosmetology, the detection of mtDNA deletions could be a useful tool to assess the effect of active ingredients on UV-irradiated human skin cells. Cosmetics 2014, 1 58 4. Conclusions Aging of human skin has been the subject of a profound interest for cosmetic industry which attempts to counteract this process. In our study we tested L-ergothioneine, one of the antioxidants used in cosmetology, and we found that L-ergothioneine enhanced the level of reduced glutathione and protected against the induction of a photoaging-associated mtDNA “common deletion”. L-Ergothioneine might be involved in the protection of mtDNA from ROS generated in the course of electron transport. In view of these results L-ergothioneine could act as an effective skin care and anti-photo-aging ingredient. On the other hand, we have shown that in cosmetology, the detection of mtDNA deletions could be a useful tool to assess the effect of active ingredients on UV-irradiated human skin cells. Acknowledgments Aleksandra Solyga-Zurek was supported by Ministry of Science and Higher Education project grant ref N N302 119735. Author Contributions Study conception and design: Karolina Bazela, Aleksandra Solyga-Zurek, Renata Debowska, Katarzyna Rogiewicz, Irena Eris; Acquisition of data: Karolina Bazela, Aleksandra Solyga-Zurek; Analysis and interpretation of data: Karolina Bazela, Aleksandra Solyga-Zurek, Renata Debowska; Drafting of manuscript: Karolina Bazela, Aleksandra Solyga-Zurek; Critical revision: Ewa Bartnik. Conflicts of Interest The authors declare no conflict of interest. References 1. Glichrest, B.A. Photoaging. J. Invest. Dermatol. 2013, 133, E2–E6. 2. Bickers, D.R.; Athar, M. Oxidative stress in the pathogenesis of skin disease. J. Invest. Dermatol. 2006, 126, 2565–2575. 3. 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Berneburg, M.; Gattermann, N.; Stege, H.; Grewe, M.; Vogelsang, K.; Ruzicka, T.; Krutmann, J. Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system. Photochem. Photobiol. 1997, 66, 271–275 29. Koch H.; Wittern, K.P.; Bergemann, J. In human keratinocytes the common deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A radiation. J. Invest. Dermatol. 2001, 117, 892–897. 30. Bourgeron, T.; Chretien, D.; Rötig, A.; Munnich, A.; Rustin, P. Fate and expression of the deleted mitochondrial DNA differ between human heteroplasmic skin fibroblast and Epstein-Barr virus-transformed lymphocyte cultures. J. Biol. Chem. 1993, 26, 19369–19376. 31. Wang, Y.N.; Wu, W.; Chen, H.C.; Fang, H. Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation. J. Dermatol. Sci. 2010, 58, 19–27. 32. Eicker, J.; Kürten, V.; Wild, S.; Riss, G.; Goralczyk, R.; Krutmann, J.; Berneburg, M. Betacarotene supplementation protects from photoaging-associated mitochondrial DNA mutation. Photochem. Photobiol. Sci. 2003, 2, 655–659. © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http:\/\/creativecommons.org\/licenses\/by\/3.0\/). Citations (6) References (31) ... l-ergothioneine is a powerful anti-oxidant is extracted at high concentrations from mushrooms such as Portabellas and Criminis species [81]. Owing to the excellent antioxidant properties ergothioneine guards the skin from oxidative and DNA damage and hence it is used in anti-aging creams and lotions [82]. Similarly, Gallic acid is a potentially known to have anti-bacterial and free radical scavenging activities. ... Eminence of Microbial Products in Cosmetic Industry Article Full-text available Jun 2019 Prabuddha Gupta Rajput Mahendrapal Singh Tejas Oza Gaurav Sanghvi View Show abstract Evaluation of the Antioxidant Capacity and Protective Effects of a Comprehensive Topical Antioxidant Containing Water-soluble, Enzymatic, and Lipid-soluble Antioxidants Article Full-text available Apr 2019 David H McDanielJacob M Waugh Lily JiangDiane B Nelson View Show abstract L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms Chapter May 2019 Saraswathy NachimuthuRuckmani Kandasamy Ramalingam PonnusamySivasudha Thilagar View Show abstract Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review Article Full-text available Nov 2016IND CROP PROD Oludemi Taofiq Ana M. Gonzalez-paramas Anabela RL MartinsIsabel C.F.R. Ferreira View Show abstract Production of ergothioneine by Methylobacterium species Article Full-text available Oct 2015 Kabir Md AlamgirSachiko Masuda Yoshiko Fujitani Akio Tani View Show abstract Designing of Biodegradable and Biocompatible Release and Delivery Systems of Selected Antioxidants Used in Cosmetology Article Full-text available Oct 2015Biomacromolecules Magdalena Maksymiak Renata Monika Debowska Karolina Bazela Grazyna Adamus View Show abstract Show more\" rel=\"noopener noreferrer\"\u003e [4\u003c\/a\u003e, \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\") L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e5\u003c\/a\u003e]. In addition to this, the mushroom is a rich source for vitamin D \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24494050\" target=\"_blank\" title=\"Photobiology of vitamin D in mushrooms and its bioavailability in humans\" rel=\"noopener noreferrer\"\u003e[6]\u003c\/a\u003e and also has many polysaccharides and triterpenes that serve as antioxidants and anti-irritants, which stimulate the natural renewal process of the skin. 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This Shiitake liquid extract makes the bioactive compounds within the mushroom readily available to you, to make you feel beautiful!\u003cbr\u003e \u003cbr\u003eTo delve deeper into the world of fungi and to learn more about Shiitake mushrooms and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003elink\u003c\/a\u003e to read our latest blogs . . .\u003cbr\u003e\u003cbr\u003e\n\u003ch3\u003eYour Shiitake Liquid Extract\u003c\/h3\u003e\nDo you want to access the bountiful benefits that the Shiitake mushroom can offer you? Then look no further, Life Cykel’s Australian sourced Shiitake liquid extract will easily supply you with all the mushroom goodness you require! \u003cbr\u003e \n\u003cp\u003e\u003cstrong\u003eCustomer Feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e“I couldn’t believe the strength of my nails and the thickness of my hair after using Shiitake for three weeks. Also, my skin feels smoother and my confidence is up. Thanks to holy Shiitake and the Life Cykel crew!”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Malia, New York\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAdd Shiitake liquid double extract directly to your coffee, smoothie, tea, soup broth or water in the evening for best results.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml\u003c\/p\u003e\n\u003cp\u003eLife Cykel's Shiitake mushrooms and liquid extracts are grown and engineered in the Northern Rivers, NSW.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle \u003cspan\u003e(60 day supply\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Australian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e \u003cspan\u003eDistilled Water, Organic Alcohol,\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eLentinula Edodes.\u003c\/em\u003e\u003c\/span\u003e\u003cspan\u003e (\u003c\/span\u003e\u003cspan\u003e\u003cem\u003eLentinula Edodes\u003c\/em\u003e.\u003c\/span\u003e\u003cspan\u003e Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eLentinula Edodes\u003c\/em\u003e.\u003c\/span\u003e\u003cspan\u003e Fruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage: \u003c\/strong\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMushroom Research:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eMushroom Research:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [2] Yamaguchi, Y., Miyahara, E. and Hihara, J. (2011). Efficacy and Safety of Orally Administered Lentinula edodes Mycelia Extract for Patients Undergoing Cancer Chemotherapy: A Pilot Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe American Journal of Chinese Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 39(03), pp.451–459.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Choi, J., Paik, D.-J., Kwon, D.Y. and Park, Y. (2014). Dietary supplementation with rice bran fermented with Lentinus edodes increases interferon-γ activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eNutrition Journal\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, [online] 13(1).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Nachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Keegan, R.-J. H., Lu, Z., Bogusz, J. M., Williams, J. E., \u0026amp; Holick, M. F. (2013). Photobiology of vitamin D in mushrooms and its bioavailability in humans. Dermato-Endocrinology, 5(1), 165–176. doi:10.4161\/derm.23321\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Cosmetic Benefits of Natural Ingredients: Mushrooms, Feverfew, Tea, and Wheat Complex. Whitney P. Bowe MD. Journal Of Drugs in Dermatology 2013. SUNY Downstate College of Medicine, Brooklyn, NY.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003e\u003cspan\u003e * This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T21:55:43+11:00","created_at":"2018-10-03T20:44:35+10:00","vendor":"Life Cykel","type":"","tags":[],"price":3495,"price_min":3495,"price_max":5295,"available":true,"price_varies":true,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":31070775771196,"title":"120ml","option1":"120ml","option2":null,"option3":null,"sku":"SDE120ml-1","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Shiitake Mushroom Liquid Extract - 120ml","public_title":"120ml","options":["120ml"],"price":5295,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"705632689189"},{"id":31070779670588,"title":"60ml","option1":"60ml","option2":null,"option3":null,"sku":"SDE60ml","requires_shipping":true,"taxable":true,"featured_image":{"id":13341076881468,"product_id":1662038736965,"position":2,"created_at":"2019-10-31T15:13:10+11:00","updated_at":"2019-10-31T15:13:10+11:00","alt":null,"width":970,"height":2000,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.shiitake.60ml.png?v=1572495190","variant_ids":[31070779670588]},"available":true,"name":"Shiitake Mushroom Liquid Extract - 60ml","public_title":"60ml","options":["60ml"],"price":3495,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"0793591581811"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Shiitake_Extract_d56ac7e7-6e3c-4977-ae47-bd096eafaae9.jpg?v=1564227735","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.shiitake.60ml.png?v=1572495190"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Shiitake_Extract_d56ac7e7-6e3c-4977-ae47-bd096eafaae9.jpg?v=1564227735","options":["Size"],"content":"\u003ch2\u003e\u003cstrong\u003eHOLY SHIITAKE\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eConnect to your inner radiance with Life Cykel’s Shiitake Mushroom Extract.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Shiitake mushroom is ranked number 2 in the global mushroom market, for its delicious taste as well as its array of health and beauty benefits \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"entinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e. This mushroom has been utilised as an edible and medicinal mushroom in Asia for many years thanks to its immune regulating and anti-ageing actions \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21598414\" target=\"_blank\" title=\"Efficacy and safety of orally administered Lentinula edodes mycelia extract for patients undergoing cancer chemotherapy: a pilot study.\" rel=\"noopener noreferrer\"\u003e[2].\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eThe Benefits of Shiitake Mushroom\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eThere are many bioactive compounds within the Shiitake mushroom, including the polysaccharide, lentinan, which is shown to increase the activity of the immune system \u003ca href=\"https:\/\/nutritionj.biomedcentral.com\/articles\/10.1186\/1475-2891-13-35\" target=\"_blank\" title=\"Dietary supplementation with rice bran fermented with Lentinus edodesincreases interferon-γ activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study\" rel=\"noopener noreferrer\"\u003e[3].\u003c\/a\u003e Further, beta-gluans and ergosterols found within the mushroom have also been seen to prevent sclerosis (the hardening of arteries), which in turn may support a healthy cardiovascular system \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"entinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e The Shiitake mushroom also works wonders for our skin and hair. The mushroom contains large quantities of the amino acid l-Ergothioneine, which helps to reduce damage from UV light\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\" Article (PDF Available) · March 2014 with 142 Reads DOI: 10.3390\/cosmetics1010051 Cite this publication Karolina Bazela 24.13Dr. Irena Eris Aleksandra Solyga-Zurek + 2 Renata Monika Debowska 23.08Independent Researcher Katarzyna Rogiewicz Show more authors Abstract Many changes related to aging at the cellular level may be due to the physiological condition of mitochondria. One of the most common types of damage of mtDNA is the so-called “common deletion” referring to a deletion of 4977 base pairs. In the skin cells this phenomenon probably is caused by oxidative damage of mtDNA induced by UV. The present study was aimed at evaluating the effect of the antioxidant l-ergothioneine on UV-induced damage in skin cells. The effect of l-ergothioneine on the reduced glutathione level was studied. The presence of the “common deletion” in human fibroblasts irradiated with UVA and treated with l-ergothioneine was evaluated by a polymerase chain reaction. We have demonstrated that l-ergothioneine enhanced the level of reduced glutathione and protected cells from the induction of a photoaging-associated mtDNA “common deletion”. In view of our results, l-ergothioneine could be an effective skin care and anti-photoaging ingredient. Discover the world's research 15+ million members 118+ million publications 700k+ research projects Join for free Figures - available via license: CC BY 4.0 Content may be subject to copyright. Chemical structure of L-ergothioneine. Chemical structure of L-ergothioneine. … . PCR primers for detection of the \u0026quot;common deletion\u0026quot; in mtDNA. . PCR primers for detection of the \u0026quot;common deletion\u0026quot; in mtDNA. … . . … +1 No caption available … Available via license: CC BY 4.0 Content may be subject to copyright. Download full-text PDF Cosmetics 2014, 1, 51-60; doi:10.3390\/cosmetics1010051 cosmetics ISSN 2079-9284 www.mdpi.com\/journal\/cosmetics Communication L-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study Karolina Bazela 1,†,*, Aleksandra Solyga-Zurek 2,†, Renata Debowska 1, Katarzyna Rogiewicz 1, Ewa Bartnik 2 and Irena Eris 1 1 Dr. Irena Eris Cosmetic Laboratories, Centre for Science and Research, Pulawska 107a, Warsaw 02-595, Poland; E-Mails: renata.debowska@eris.pl (R.D.); katarzyna.rogiewicz@eris.pl (K.R.); irena.eris@eris.pl (I.E.) 2 Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, Warsaw 02-106, Poland; E-Mails: asolyga@biol.uw.edu.pl (A.S.-Z.); ebartnik@igib.uw.edu.pl (E.B.) † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: karolina.bazela@eris.pl; Tel.: +48-22-717-1248; Fax: +48-22-757-0612. Received: 31 December 2013; in revised form: 10 March 2014 \/ Accepted: 11 March 2014 \/ Published: 20 March 2014 Abstract: Many changes related to aging at the cellular level may be due to the physiological condition of mitochondria. One of the most common types of damage of mtDNA is the so-called “common deletion” referring to a deletion of 4977 base pairs. In the skin cells this phenomenon probably is caused by oxidative damage of mtDNA induced by UV. The present study was aimed at evaluating the effect of the antioxidant L-ergothioneine on UV-induced damage in skin cells. The effect of L-ergothioneine on the reduced glutathione level was studied. The presence of the “common deletion” in human fibroblasts irradiated with UVA and treated with L-ergothioneine was evaluated by a polymerase chain reaction. We have demonstrated that L-ergothioneine enhanced the level of reduced glutathione and protected cells from the induction of a photoaging-associated mtDNA “common deletion”. In view of our results, L-ergothioneine could be an effective skin care and anti-photoaging ingredient. Keywords: L-ergothioneine; common deletion; mitochondria; photoaging OPEN ACCESS Cosmetics 2014, 1 52 1. Introduction Ultraviolet irradiation is one of the most important environmental factors in the development of a number of skin conditions, ranging from photoaging to cancer. UVA\/B rays penetrate into the skin, reach cells and are absorbed by proteins, lipids, and nuclear and mitochondrial DNA, causing a cascade of oxidative events that can result in progressive deterioration of cellular structure and function [1–3]. There are many theories of aging and a number of them encompass the role of mitochondria in this process. Mitochondria are responsible for producing approximately 90% of the cellular energy in the process of oxidative phosphorylation where electrons from NADH and FADH2 are transferred to oxygen. This generates a significant amount of reactive oxygen species (ROS). Mitochondria are able to counteract the production of ROS with antioxidant defense systems which can detoxify the amount of ROS produced, however, some ROS do evade these processes and are able to damage mitochondrial DNA (mtDNA) as well as proteins and lipids. Mitochondria contain their own DNA (mtDNA), which is distinct from nuclear DNA and more susceptible to damage. Mitochondrial DNA mutations and deletions have been shown to accumulate in many tissues in mammals during aging. mtDNA mutations are thought to arise due to the close proximity to the inner membrane where reactive oxygen species are continually produced in the electron transport chain. This, along with the absence of protective histones and impaired DNA photoproduct repair makes mtDNA a sensitive marker of UV-induced DNA damage [4,5]. It has been shown that photoaged skin is characterized by increased mutations in the mitochondrial (mt) genome [6]. The most frequently reported deletion is a large-scale (4977 bp) deletion also called the “common deletion” (CD). In human skin CD has been shown to occur more frequently with increasing sun exposure and thus appears to be a useful marker rather for UVA induced alterations than for chronological aging [7–10]. The use of antioxidants is an effective approach to prevent symptoms related to photo-induced aging of the skin. Many antioxidants have long been used in cosmetology. L-Ergothioneine (EGT) is an unusual sulphur-containing derivative of an amino acid, histidine, which is acquired by mammals exclusively in their diet. L-Ergothioneine has two functional groups: L-thiol (SH) group and quaternary ammonium group N–(CH3)3 (Figure 1). EGT’s thiol group implies an antioxidant role. The quaternary group EGT resembles carnitine and transfers fatty acids into the mitochondria, therefore increasing the ATP level in cells. EGT is concentrated in cells and tissues frequently exposed to oxidative stress. Numerous in vitro assays have demonstrated the antioxidant and cytoprotective capabilities of EGT against a wide range of cellular stressors [11–13]. Figure 1. Chemical structure of L-ergothioneine. Cosmetics 2014, 1 53 On the basis of these data on the antioxidant activity of L-ergothioneine we found it interesting to study the effect of this substance on UV-induced alterations in skin cell cultures, particularly on mtDNA damage. 2. Experimental Section 2.1. Cell Cultures KB cells (epidermoid carcinoma cell line KB, American Type Culture Collection (ATCC), Manassas, VA, USA) were grown in standard RPMI medium (Invitrogen, Carlsbad, CA, USA), supplemented with 10% fetal calf serum, 2 mM L-glutamine and antibiotics (100 U\/mL penicillin, 0.25 µg\/mL streptomycin sulfate) at 37 °C in 5% CO2. The KB cell line was used as a model representing human keratinocytes. Skin samples, obtained from donors undergoing cosmetic surgery, were treated with dispase II solution (5 mg\/mL, Sigma-Aldrich, St. Louis, MO, USA) at 4 °C for 16 h, followed by separation of dermal and epidermal layers with tweezers. Next, the dermis was cut into ~1 mm2 fragments and treated with 2 mg\/mL collagenase and 0.1 mg\/mL DNase (Sigma-Aldrich, St. Louis, MO, USA) overnight. Liberated cells were seeded into cell culture flasks for culture. Primary human fibroblasts were grown in standard DMEM medium (Invitrogen, Carlsbad, CA, USA), supplemented with 10% fetal calf serum (Invitrogen, Carlsbad, CA, USA), 10 mM HEPES, 2 mM L-glutamine and antibiotics (100 U\/mL penicillin, 0.25 µg\/mL streptomycin sulfate) and 50 µg\/mL uridine, with or without 20 µM L-ergothioneine (Barnet Products Corp.,Englewood Cliffs, NJ, USA), at 37 °C in 5% CO2. Confluent passages between 2 and 8 were used. 2.2. UVB Irradiation Confluent KB cells (control and treated with 20 µM L-ergothioneine (Barnet Products Corp., Englewood Cliffs, NJ, USA)) were exposed to UVB (300 J\/m2, fluorescent bulb TL12 Philips, emission peak at 313 nm) through phosphate buffered saline. 2.3. UVA Irradiation The presence of the “common deletion” was evaluated in fibroblasts derived from 2 female donors aged 38 and 45 and from 2 male donors aged 30 and 42. Cells were grown in the presence of 50 µg\/mL uridine (Sigma-Aldrich, St. Louis, MO, USA), with or without 20 µM L-ergothioneine and irradiated with 3 doses (8 J\/cm2, fluorescent bulb GE F4T5\/BLB, emission peak at 368 nm) of UVA per day, through phosphate buffered saline. This procedure was repeated for 4 consecutive days during 3 weeks. 2.4. Colorimetric Determination of Reduced Glutathione (GSH) GSH level was measured using the GSH\/GSSG-412 assay (OxisResearchTM, Portland, OR, USA)—colorimetric determination of reduced and oxidized glutathione. The method employs Ellmanʼs reagent (5,5'-dithiobis-2-nitrobenzoic acid—DTNB), which reacts with GSH to form a product which is spectrophotometrically detectable at 412 nm. The change in absorbance at 412 nm is Cosmetics 2014, 1 54 a linear function of the GSH concentration in the reaction mixture [14]. The protein concentration was measured with Bradford Reagent (Sigma-Aldrich, St. Louis, MO, USA) [15]. Three independent experiments were performed. Comparisons between control and post-treatment measurements were performed using an unpaired Student’s t-test. Probability values of p \u0026lt; 0.05 were considered statistically significant. 2.5. “Common Deletion” (CD) PCR Phenol-chloroform extraction of total DNA and PCR (Fermentas, Lithuania, Vilnius) were performed according to standard protocols. PCR reaction mixture, for both primer pairs, contained: F primer 2 μM; R primer 2 μM; dNTP 20 mM; Taq Buffer with (NH4)2SO4 and 20 mM MgCl2 1×; Taq polymerase 1 U; DNA 100 ng. All reactions were performed in 25 µL volume in the following conditions: the denaturation step was carried out at 94 C for 3 min, 35 cycles of 94 C for 30 s, 58 C for 30 s, 72 C for 1 min, and a final extension of 72 C for 7 min. See Table 1 for primers used. Table 1. PCR primers for detection of the “common deletion” in mtDNA. PCR primer Orientation Position MT1A F 8224-8247 MT1C F 13176-13198MT2 R 13501-13477PCR reaction with primers MT1A–MT2 was carried out, amplifying a fragment 300 bp in length when the “common deletion” was present. In order to ensure that the absence of CD PCR product is caused by the absence of CD and not by an incorrect PCR reaction, PCR with primers MT1A–MT2 was performed. A corresponding product 325 bp in length is obtained when the mitochondrial genome without the deletion is present and thus serves as a control for the PCR reaction. As a positive control of the PCR reaction, DNA isolated from a patient with a previously confirmed common deletion in mtDNA was used. PCR products were detected by electrophoresis on a 1.5% agarose gel with ethidium bromide against a DNA molecular-weight marker. The gel was photographed under UV transillumination. Three independent experiments were performed. 3. Results and Discussion 3.1. L-Ergothioneine Increases the Reduced Glutathione (GSH) Level The tripeptide glutathione (GSH) is the most abundant intracellular non-protein thiol. It is present predominantly in a reduced form (GSH), which is the biologically active form. Over the years, a great deal of information has been gathered on the role of GSH in maintaining the intracellular reduction–oxidation (redox) environment including antioxidant defense via direct interaction with reactive oxygen\/nitrogen species (ROS\/RNS) or via activities of detoxification enzymes like GSH peroxidases and GSH-S-transferases [16]. In our study we tested the effect of L-ergothioneine on the reduced glutathione (GSH) level in the KB cell line using the GSH\/GSSG-412 colorimetric assay. Our studies showed that L-ergothioneine at the 20 µM concentration (chosen according to our previous studies [17]) increased the reduced glutathione (GSH) level both in control and UVB irradiated Cosmetics 2014, 1 55 KB cells (Table 2). Changes between GSH level in control compared with GSH level after treatment with L-ergothioneine, both in cells exposed and unexposed to UVB, were statistically significant. The UVB light was chosen for the irradiation of KB cells since it is the light of the UVB spectrum that is for the most part absorbed by the epidermis in vivo [18]. UVB may also damage epidermal cells both directly and indirectly by inducing the formation of reactive oxygen species, i.e., the superoxide anion [19]. Thus, it was deemed necessary to study the antioxidative effect of EGT on UVB irradiated epidermis. Table 2. Quantitative determination of glutathione (GSH) level in KB cells. KB cells µmol GSH\/µg protein −UVB +UVB (300 J\/m2) control 6.07 ± 0.15 3.03 ± 0.02 20 µM L-ergothioneine 15.37 ± 0.13 4.65 ± 0.06 Our results are in line with numerous studies demonstrating that L-ergothioneine is an integral component of the cellular antioxidant defense system. It scavenges hydroxyl and peroxynitrite radicals as well as the superoxide anion radical and singlet oxygen. In vitro tests have also demonstrated that EGT also has strong copper chelating ability—it potentially inhibits tyrosinase activity [20–22]. Moreover, in vitro tests have demonstrated that in cultured fibroblasts EGT suppressed the tumor necrosis factor α (TNF α) up-regulation induced by UVB irradiation. In addition in fibroblasts exposed to UVA, EGT suppressed the expression of matrix metalloproteinase 1 (MMP 1) protein [23]. EGT also inhibited nuclear factor kβ (NF kβ) activation and limited the transcriptional activation of the gene for interleukin 8 (IL-8)—a chemotaxin which might account for neutrophil recruitment [24]. It has been demonstrated that EGT is a more powerful antioxidant than either coenzyme Q(10) or idebenone due to its relatively greater efficiency in directly scavenging free radicals and in protecting cells from UV-induced ROS [25]. Recently, a high specific transporter for EGT (ETT) was identified in mammalian tissues, which explains the high tissue levels of EGT and implies a physiological role. Depletion of ETT leads to augmented oxidative stress and cell death. ETT is highly concentrated in the plasma membrane and mitochondria [11]. 3.2. L-Rrgothioneine Shows Protective Properties against the Induction of a Photoaging-Associated mtDNA “Common Deletion” One of the best described mt deletions, the 4977 bp “common deletion”, is known to be involved in photoaging of the skin. Intraindividual comparison studies have revealed that the “common deletion” is increased up to 10-fold in photoaged skin, as compared with sun-protected skin of the same individuals [7]. The objective of our study was to evaluate the effect of L-ergothioneine on the occurrence of mtDNA “common deletion” in UV-irradiated human primary fibroblasts obtained from various donors. For the experiments on dermal cells only UVA irradiation was performed, since the great majority of UVB rays is absorbed by the epidermis and hence never reaches the dermal level [18]. UVA is known to cause mainly indirect damage to cellular structures and nucleic acids by inducing the formation of radical oxygen and nitrogen species but may also be responsible for single- and double-strands breaks in DNA [19]. Thus, exposure to UVA may be one of the main causes Cosmetics 2014, 1 56 of mtDNA mutations including mtDNA deletions [26]. In our experiments, in fibroblasts which were not exposed to UVA we did not observe the “common deletion” after DNA isolation nor during 3 weeks of culture (Figure 2, lanes 9, 11 and 13). When we incubated fibroblasts with L-ergothioneine we also observed no “common deletion” PCR product (Figure 3, lanes 9, 11 and 13). To summarize this part of our study: first of all, cultured fibroblasts isolated from various donors did not initially show the “common deletion”. Secondly, L-ergothioneine, itself, had no influence on the presence of the “common deletion”. Figure 2. Representative PCR analysis of the presence of the “common deletion” in a culture of human fibroblasts incubated with and without UVA exposure, without the presence of L-ergothioneine. M, molecular weight marker; C, control PCR reaction, confirming the presence of mtDNA; 1, fibroblasts after 1 week with UVA exposure; 3, fibroblasts after 2 weeks with UVA exposure; 5, fibroblasts after 3 weeks with UVA exposure; 7, positive control—DNA from a patient with a previously confirmed presence of “common deletion”; 9, fibroblasts after 1 week without UVA exposure; 11, fibroblasts after 2 weeks without UVA exposure; 13 fibroblasts after 3 weeks without UVA exposure. We were able to induce the “common deletion” using repetitive UVA irradiation in cultured human fibroblasts derived from two donors (Figure 2, lanes 1, 3 and 5) suggesting that there is an individual susceptibility to the induction of CD, at least in our in vitro model. Due to the fact that our “common deletion” analysis was performed on fibroblasts isolated from four donors, this requires further studies. When fibroblasts were irradiated and co-incubated with 20 µM L-ergothioneine we did not observe the “common deletion” even after 3 weeks with UVA exposure, suggesting that L-ergothioneine may prevent the formation of this particular damage in mtDNA (Figure 3, lanes 1, 3 and 5). Our results are in accordance with the previous studies where repetitive exposure of keratinocytes, fibroblasts or Cosmetics 2014, 1 57 human skin to UVA at physiological doses was found to induce mutations of mtDNA [7,27–29]. Interestingly, it has been shown that in fibroblasts the level of CD is decreasing with prolonged culture, which can be counteracted with uridine supplementation of culture media [6,7,30]. For this reason, uridine supplementation was employed during all CD analyses in this study. Figure 3. Representative PCR analysis of the presence of the “common deletion” in a culture of human fibroblasts incubated with and without UVA exposure, in the presence of 20 µM L-ergothioneine. M, molecular weight marker; C, control PCR reaction, confirming the presence of mtDNA; 1, fibroblasts after 1 week with UVA exposure; 3, fibroblasts after 2 weeks with UVA exposure; 5, fibroblasts after 3 weeks with UVA exposure; 7, positive control—DNA from a patient with a previously confirmed presence of “common deletion”; 9, fibroblasts after 1 week without UVA exposure; 11, fibroblasts after 2 weeks without UVA exposure; 13, fibroblasts after 3 weeks without UVA exposure. Protection against the induction of a photoaging-associated mtDNA mutation has been also previously shown for two other widely applied cosmetic actives—β-carotene and genistein [31,32]. Our results demonstrated that L-ergothioneine may protect skin cells against some UV-induced damage; in particular against the occurrence of mitDNA “common deletion”. Further studies are required to assess the full-spectrum of L-ergothioneine’s protective activity. We conclude that L-ergothioneine, as an active compound of cosmetic products, shows considerable promise as an effective agent against the aging process. On the other hand, we have shown that in cosmetology, the detection of mtDNA deletions could be a useful tool to assess the effect of active ingredients on UV-irradiated human skin cells. Cosmetics 2014, 1 58 4. Conclusions Aging of human skin has been the subject of a profound interest for cosmetic industry which attempts to counteract this process. In our study we tested L-ergothioneine, one of the antioxidants used in cosmetology, and we found that L-ergothioneine enhanced the level of reduced glutathione and protected against the induction of a photoaging-associated mtDNA “common deletion”. L-Ergothioneine might be involved in the protection of mtDNA from ROS generated in the course of electron transport. In view of these results L-ergothioneine could act as an effective skin care and anti-photo-aging ingredient. On the other hand, we have shown that in cosmetology, the detection of mtDNA deletions could be a useful tool to assess the effect of active ingredients on UV-irradiated human skin cells. Acknowledgments Aleksandra Solyga-Zurek was supported by Ministry of Science and Higher Education project grant ref N N302 119735. Author Contributions Study conception and design: Karolina Bazela, Aleksandra Solyga-Zurek, Renata Debowska, Katarzyna Rogiewicz, Irena Eris; Acquisition of data: Karolina Bazela, Aleksandra Solyga-Zurek; Analysis and interpretation of data: Karolina Bazela, Aleksandra Solyga-Zurek, Renata Debowska; Drafting of manuscript: Karolina Bazela, Aleksandra Solyga-Zurek; Critical revision: Ewa Bartnik. Conflicts of Interest The authors declare no conflict of interest. References 1. Glichrest, B.A. Photoaging. J. Invest. Dermatol. 2013, 133, E2–E6. 2. Bickers, D.R.; Athar, M. Oxidative stress in the pathogenesis of skin disease. J. Invest. Dermatol. 2006, 126, 2565–2575. 3. Puizina-Ivic, N. Skin aging. Acta Derm. 2008, 17, 47–54. 4. Tońska, K.; Sołyga, A.; Bartnik, E. Mitochondria and aging: Innocent bystanders or guilty parties? J. Appl. Genet. 2009, 50, 55–62. 5. Alexeyev, M.F.; LeDoux, S.P.; Wilson, G.L. Mitochondrial DNA and aging. Clin. Sci. 2004, 107, 355–364. 6. Krishnan, K.J.; Greaves, L.C.; Reeve, A.K.; Turnbull, D. The ageing mitochondrial genome. Nucleic Acids Res. 2007, 35, 7399–7405. 7. Birch-Machin, M.A.; Tindall, M.; Turner, R.; Haldane, F.; Rees, J.L. Mitochondrial DNA deletions in human skin reflect photo rather than chronologic aging. J. Invest. Dermatol. 1998, 110, 149–152. 8. Yang, J.H.; Lee, H.C.; Lin, K.J.; Wei, Y.H. A specific 4977-bp deletion of mitochondrial DNA in human ageing skin. Arch. Dermatol. Res. 1994, 286, 386–390. Cosmetics 2014, 1 59 9. Yang, J.H.; Lee, H.C.; Wei, Y.H. Photoageing-associated mitochondrial DNA length mutations in human skin. Arch. Dermatol. Res. 1995, 287, 641–648. 10. Ray, A.J.; Turner, R.; Nikaido, O.; Rees, J.L.; Birch-Machin, M.A. The spectrum of mitochondrial DNA deletions is a ubiquitous marker of ultraviolet radiation exposure in human skin. J. Invest. Dermatol. 2000, 115, 674–679. 11. Paul, B.D.; Snyder, S.H. The unusual amino acid L-ergothioneine is a physiologic cytoprotectant. Cell Death Differ. 2010, 17, 1134–1140. 12. Cheah, I.K.; Halliwell, B. Ergothioneine; antioxidant potential, physiological function and role in disease. Biochim. Biophys. Acta 2012, 1822, 784–793. 13. Markova, N.G.; Karaman-Jurukovska, N.; Dong, K.K.; Damaghi, N.; Smiles, K.A.; Yarosh, D.B. Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system. Free Radic. Biol. Med. 2009, 46, 1168–1176. 14. Tietze, F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal. Biochem. 1969, 27, 502–522. 15. Bradford, M.M. Rapid and sensitive method for quantitation of microgram quantities of protein utilising principle of protein dye binding. Anal. Biochem. 1976, 72, 248–254. 16. Dickinson, D.A.; Forman, H.J. Cellular glutathione and thiols metabolism. Biochem. Pharmacol. 2002, 64, 1019–1026. 17. Bazela, K.; Debowska, R.; Zielinska, A.; Jastrzebska-Brucka, E.; Kawczuga, D.; Eris, I. Protective role of Antioxidant Complex (AC) on human skin cells. In Proceedings of the 3rd International Conference on Oxidative Stress in Skin Medicine and Biology, Andros, Greece, 21–24 September 2006. 18. Kligman, L.H. Photoaging. Manifestations, prevention, and treatment. Dermatol. Clin. 1986, 4, 517–528. 19. Ichihashi, M.; Ueda, M.; Budiyanto, A.; Bito, T.; Oka, M.; Fukunaga, M.; Tsuru, K.; Horikawa, T. UV-induced skin damage. Toxicology 2003, 189, 21–39. 20. Aruoma, O.I.; Spencer, J.P.; Mahmood, N. Protection against oxidative damage and cell death by the natural antioxidant ergothioneine. Food Chem. Toxicol. 1999, 37, 1043–1053. 21. Laurenza, I.; Colognato, R.; Migliore, L.; Del Prato, S.; Benzi, L. Modulation of palmitic acid-induced cell death by ergothioneine: Evidence of an anti-inflammatory action. Biofactors 2008, 33, 237–247. 22. Franzoni, F.; Colognato, R.; Galetta, F.; Laurenza, I.; Barsotti, M.; Di Stefano, R.; Bocchetti, R.; Regoli, F.; Carpi, A.; Balbarini, A.; et al. An in vitro study on the free radical scavenging capacity of ergothioneine: Comparison with reduced glutathione, uric acid and trolox. Biomed. Pharmacother. 2006, 60, 453–457. 23. Obayashi, K.; Kurihara, K.; Okano, Y.; Masaki, H.; Yarosh, D.B. L-Ergothioneine scavenges superoxide and singlet oxygen and suppresses TNF-α and MMP-1 expression in UV-irradiated human dermal fibroblasts. J. Cosmet. Sci. 2005, 56, 17–27. 24. Rahman, I.; Gilmour, P.S.; Jimenez, L.A.; Biswas, S.K.; Antonicelli, F.; Aruoma, O.I. Ergothioneine inhibits oxidative stress- and TNF-α-induced NF-κB activation and interleukin-8 release in alveolar epithelial cells. Biochem. Biophys. Res. Commun. 2003, 302, 860–864. Cosmetics 2014, 1 60 25. Dong, K.K.; Damaghi, N.; Kibitel, J.; Canning, M.T.; Smiles, K.A.; Yarosh, D.B. A comparison of the relative antioxidant potency of L-ergothioneine and idebenone. J. Cosmet. Dermatol. 2007, 6, 183–188. 26. Krishnan, K.J.; Reeve, A.K.; Samuels, D.C.; Chinnery, P.F.; Blackwood, J.K.; Taylor, R.W.; Wanrooij, S.; Spelbrink, J.N.; Lightowlers, R.N.; Turnbull, D.M. What causes mitochondrial DNA deletions in human cells? Nat. Genet. 2008, 40, 275–279. 27. Berneburg, M.; Plettenberg, H.; Medve-König, K.; Pfahlberg, A.; Gers-Barlag, H.; Gefeller, O.; Krutmann, J. Induction of the photoaging-associated mitochondrial common deletion in vivo in normal human skin. J. Invest. Dermatol. 2004, 122, 1277–1283. 28. Berneburg, M.; Gattermann, N.; Stege, H.; Grewe, M.; Vogelsang, K.; Ruzicka, T.; Krutmann, J. Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system. Photochem. Photobiol. 1997, 66, 271–275 29. Koch H.; Wittern, K.P.; Bergemann, J. In human keratinocytes the common deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A radiation. J. Invest. Dermatol. 2001, 117, 892–897. 30. Bourgeron, T.; Chretien, D.; Rötig, A.; Munnich, A.; Rustin, P. Fate and expression of the deleted mitochondrial DNA differ between human heteroplasmic skin fibroblast and Epstein-Barr virus-transformed lymphocyte cultures. J. Biol. Chem. 1993, 26, 19369–19376. 31. Wang, Y.N.; Wu, W.; Chen, H.C.; Fang, H. Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation. J. Dermatol. Sci. 2010, 58, 19–27. 32. Eicker, J.; Kürten, V.; Wild, S.; Riss, G.; Goralczyk, R.; Krutmann, J.; Berneburg, M. Betacarotene supplementation protects from photoaging-associated mitochondrial DNA mutation. Photochem. Photobiol. Sci. 2003, 2, 655–659. © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http:\/\/creativecommons.org\/licenses\/by\/3.0\/). Citations (6) References (31) ... l-ergothioneine is a powerful anti-oxidant is extracted at high concentrations from mushrooms such as Portabellas and Criminis species [81]. Owing to the excellent antioxidant properties ergothioneine guards the skin from oxidative and DNA damage and hence it is used in anti-aging creams and lotions [82]. Similarly, Gallic acid is a potentially known to have anti-bacterial and free radical scavenging activities. ... Eminence of Microbial Products in Cosmetic Industry Article Full-text available Jun 2019 Prabuddha Gupta Rajput Mahendrapal Singh Tejas Oza Gaurav Sanghvi View Show abstract Evaluation of the Antioxidant Capacity and Protective Effects of a Comprehensive Topical Antioxidant Containing Water-soluble, Enzymatic, and Lipid-soluble Antioxidants Article Full-text available Apr 2019 David H McDanielJacob M Waugh Lily JiangDiane B Nelson View Show abstract L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms Chapter May 2019 Saraswathy NachimuthuRuckmani Kandasamy Ramalingam PonnusamySivasudha Thilagar View Show abstract Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review Article Full-text available Nov 2016IND CROP PROD Oludemi Taofiq Ana M. Gonzalez-paramas Anabela RL MartinsIsabel C.F.R. Ferreira View Show abstract Production of ergothioneine by Methylobacterium species Article Full-text available Oct 2015 Kabir Md AlamgirSachiko Masuda Yoshiko Fujitani Akio Tani View Show abstract Designing of Biodegradable and Biocompatible Release and Delivery Systems of Selected Antioxidants Used in Cosmetology Article Full-text available Oct 2015Biomacromolecules Magdalena Maksymiak Renata Monika Debowska Karolina Bazela Grazyna Adamus View Show abstract Show more\" rel=\"noopener noreferrer\"\u003e [4\u003c\/a\u003e, \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\") L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e5\u003c\/a\u003e]. In addition to this, the mushroom is a rich source for vitamin D \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24494050\" target=\"_blank\" title=\"Photobiology of vitamin D in mushrooms and its bioavailability in humans\" rel=\"noopener noreferrer\"\u003e[6]\u003c\/a\u003e and also has many polysaccharides and triterpenes that serve as antioxidants and anti-irritants, which stimulate the natural renewal process of the skin. Therefore this mushroom can be particularly effective in skin care applications that protect against photoageing and improving skin elasticity \u003ca href=\"https:\/\/jddonline.com\/articles\/dermatology\/S1545961613S0133X\/\" target=\"_blank\" title=\"Cosmetic Benefits of Natural Ingredients: Mushrooms, Feverfew, Tea, and Wheat Complex\" rel=\"noopener noreferrer\"\u003e[7]\u003c\/a\u003e.\u003cbr\u003e\u003cbr\u003e\n\u003ch3\u003e\u003cstrong\u003eThe Use of Shiitake Liquid Extract\u003c\/strong\u003e\u003c\/h3\u003e\nThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today. As is the effortless way of incorporating these mushroom extracts into your day to day life. This Shiitake liquid extract makes the bioactive compounds within the mushroom readily available to you, to make you feel beautiful!\u003cbr\u003e \u003cbr\u003eTo delve deeper into the world of fungi and to learn more about Shiitake mushrooms and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003elink\u003c\/a\u003e to read our latest blogs . . .\u003cbr\u003e\u003cbr\u003e\n\u003ch3\u003eYour Shiitake Liquid Extract\u003c\/h3\u003e\nDo you want to access the bountiful benefits that the Shiitake mushroom can offer you? Then look no further, Life Cykel’s Australian sourced Shiitake liquid extract will easily supply you with all the mushroom goodness you require! \u003cbr\u003e \n\u003cp\u003e\u003cstrong\u003eCustomer Feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e“I couldn’t believe the strength of my nails and the thickness of my hair after using Shiitake for three weeks. Also, my skin feels smoother and my confidence is up. Thanks to holy Shiitake and the Life Cykel crew!”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Malia, New York\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAdd Shiitake liquid double extract directly to your coffee, smoothie, tea, soup broth or water in the evening for best results.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml\u003c\/p\u003e\n\u003cp\u003eLife Cykel's Shiitake mushrooms and liquid extracts are grown and engineered in the Northern Rivers, NSW.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle \u003cspan\u003e(60 day supply\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Australian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e \u003cspan\u003eDistilled Water, Organic Alcohol,\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eLentinula Edodes.\u003c\/em\u003e\u003c\/span\u003e\u003cspan\u003e (\u003c\/span\u003e\u003cspan\u003e\u003cem\u003eLentinula Edodes\u003c\/em\u003e.\u003c\/span\u003e\u003cspan\u003e Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eLentinula Edodes\u003c\/em\u003e.\u003c\/span\u003e\u003cspan\u003e Fruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage: \u003c\/strong\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMushroom Research:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eMushroom Research:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [2] Yamaguchi, Y., Miyahara, E. and Hihara, J. (2011). Efficacy and Safety of Orally Administered Lentinula edodes Mycelia Extract for Patients Undergoing Cancer Chemotherapy: A Pilot Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe American Journal of Chinese Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 39(03), pp.451–459.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Choi, J., Paik, D.-J., Kwon, D.Y. and Park, Y. (2014). Dietary supplementation with rice bran fermented with Lentinus edodes increases interferon-γ activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eNutrition Journal\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, [online] 13(1).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Nachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Keegan, R.-J. H., Lu, Z., Bogusz, J. M., Williams, J. E., \u0026amp; Holick, M. F. (2013). Photobiology of vitamin D in mushrooms and its bioavailability in humans. Dermato-Endocrinology, 5(1), 165–176. doi:10.4161\/derm.23321\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Cosmetic Benefits of Natural Ingredients: Mushrooms, Feverfew, Tea, and Wheat Complex. Whitney P. Bowe MD. Journal Of Drugs in Dermatology 2013. SUNY Downstate College of Medicine, Brooklyn, NY.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003e\u003cspan\u003e * This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/details\u003e"} [{"id":92048490565,"handle":"all","title":"All","updated_at":"2019-11-18T23:35:01+11:00","body_html":"","published_at":"2019-02-18T10:20:43+11:00","sort_order":"best-selling","template_suffix":"","disjunctive":false,"rules":[{"column":"variant_price","relation":"greater_than","condition":"0"},{"column":"variant_inventory","relation":"greater_than","condition":"0"},{"column":"type","relation":"not_equals","condition":"Insurance"}],"published_scope":"web"},{"id":80859955269,"handle":"liquid-extracts","title":"Liquid Mushroom Extract - The Elixir of Life","updated_at":"2019-11-18T23:35:01+11:00","body_html":"\u003cp\u003eGive your body and mind proper support on your journey to vitality and longevity. Find the best organic liquid Mushroom extracts at Life Cykel today!\u003c\/p\u003e\n\u003cp\u003eFor thousands of years, traditional medicine has used mushroom tinctures as a primary means of treatment, due to the vast array of health benefits they provide. The positive outcomes and the strong faith in the power of the mushroom liquid extract, has gained them the title ”\u003cstrong\u003e\u003cem\u003eelixirs of life\u003c\/em\u003e\u003c\/strong\u003e”. These beneficial mushrooms have mainly been used in Asia \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e, but are now spreading to all corners of the world, and are being named \u003cstrong\u003e\u003cem\u003efunctional mushrooms.\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdetails\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eFunctional mushrooms are considered a superfood and are now commonly used as dietary supplements \u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09168451.2018.1431519?journalCode=tbbb20\" target=\"_blank\" title=\"Biologically functional molecules from mushroom-forming fungi. \" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003eToday, we are discovering more and more about the benefits of using these mushrooms and extensive research is being undertaken to understand the bioactive compounds within the mushrooms that provide them with such power.\u003c\/p\u003e\n\u003cp\u003e By using Life Cykel’s mushroom liquid extract, as a supplement in your everyday diet, you can effortlessly give your body and mind the proper support it requires on your mission of health and wellness.\u003c\/p\u003e\n\u003cp\u003e Life Cykel's liquid \u003cstrong\u003e\u003cem\u003edouble\u003c\/em\u003e\u003c\/strong\u003e extracts have been carefully created to be some of the most potent mushroom extracts in the world. Our extract range includes Reishi, Cordyceps, Shiitake, Lion's Mane and Turkey Tail mushrooms.\u003c\/p\u003e\n\u003cp\u003eNot only do we provide you with the best mushroom liquid extract, when producing our extracts we aim to integrate Circular Economy principles wherever possible and where available we're using Australian native mushroom strains that have been meticulously infused with Australian native, wild harvested Kakadu Plum.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/lions-mane-mushroom-liquid-extract\" title=\"Buy Lion's Mane Liquid Extract\"\u003eLion’s Mane Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eLion's Mane Mushroom is known for its positive effects on cognitive health \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24266378\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" rel=\"noopener noreferrer\"\u003e[3]\u003c\/a\u003e. This mushroom is rich in bioactive components \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26244378\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" rel=\"noopener noreferrer\"\u003e[5]\u003c\/a\u003e, which could be responsible for some important physiological activities, this includes antioxidant and anti- inflammatory activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26559695\" title=\"The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\"\u003e [6\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906890\/\" target=\"_blank\" title=\"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities\" rel=\"noopener noreferrer\"\u003e7]\u003c\/a\u003e and neural growth \u003ca href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jnatprod.6b00371?src=recsys\" target=\"_blank\" title=\"Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e, improving memory and focus as well as enhancing your dreams and mood \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31118969\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?\" rel=\"noopener noreferrer\"\u003e[8]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/cordyceps-mushroom-liquid-extract\" title=\"Buy Cordyceps Liquid Extract\"\u003eCordyceps Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eCordyceps mushroom is an extraordinary mushroom. The bioactive compounds within the mushroom, show to promote anti-inflammatory, anti-microbial and anti-oxidative activities (anti-ageing) [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=86265\" target=\"_blank\" title=\"The Effect of the Hot Water Extracts of the Paecilomyces hepiali and Cordyceps militaris Mycelia on the Growth of Gastrointestinal Bacteria\" rel=\"noopener noreferrer\"\u003e10]\u003c\/a\u003e, as well as having beneficial effects on lipid metabolism [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24231073\" target=\"_blank\" title=\"Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice.\" rel=\"noopener noreferrer\"\u003e11]\u003c\/a\u003e and may improve your endurance to prolonged and high intensity exercise \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e[9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5236007\/\" target=\"_blank\" title=\"Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation\" rel=\"noopener noreferrer\"\u003e12\u003c\/a\u003e,\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28094746\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming.\" rel=\"noopener noreferrer\"\u003e13\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/reishi-mushroom-liquid-extract\" title=\"Buy Reishi Liquid Extract\"\u003eReishi Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eFor many millennia the Reishi mushroom has been used to treat a variety of diseases, including cardiovascular diseases and insomnia \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e[14]\u003c\/a\u003e. The constituents within the mushroom may help to enhance anti-microbial, anti-oxidant and immunomodulating activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e [14\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ingentaconnect.com\/contentone\/ben\/cpb\/2016\/00000017\/00000003\/art00010\" target=\"_blank\" title=\"Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents\" rel=\"noopener noreferrer\"\u003e15\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24386913\" target=\"_blank\" title=\"Concentration variation and molecular characteristics of soluble (1,3;1,6)-β-D-glucans in submerged cultivation products of Ganoderma lucidum mycelium\" rel=\"noopener noreferrer\"\u003e16\u003c\/a\u003e]. The mushroom is also well known for its beneficial effects on sleep and relaxation [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e17\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Extract+of+Ganoderma+lucidum+prolongs+sleep+time+in+rats\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats\" rel=\"noopener noreferrer\"\u003e18\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/turkey-tail-mushroom-liquid-extract\" title=\"Buy Turkey Tail Liquid Extract\"\u003eTurkey Tail Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eThe Turkey Tail mushroom is mainly consumed to regulate the immune system. However, more recent research is also showing evidence that the mushroom may have the ability of modulating the composition of the human microbiome [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25006989\" target=\"_blank\" title=\"Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial\" rel=\"noopener noreferrer\"\u003e19\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23435630\" target=\"_blank\" title=\"Trametes versicolor extract modifies human fecal microbiota composition in vitro.\" rel=\"noopener noreferrer\"\u003e20]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/shiitake-mushroom-liquid-extract\" title=\"Buy Shiitake Liquid Extract\"\u003eShiitake mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eShiitake mushrooms have been utilised for their anti-sclerotic (reduce hardening of arteries) activities as well as helping to reduce damage from UV light and helping to increase the renewal process of the skin, therefore this mushroom could be considered as an effective anti-photoaging and skin care ingredient \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\"L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e[21,\u003c\/a\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\"l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study\" rel=\"noopener noreferrer\"\u003e 22,\u003c\/a\u003e \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e23]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eLearn more about our mushrooms by browsing our range of liquid mushroom extracts below or click \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003ehere\u003c\/u\u003e\u003c\/a\u003e to read our latest blogs on these fantastic fungi!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2] Choi, J.-H. (2018). Biologically functional molecules from mushroom-forming fungi. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eBioscience, Biotechnology, and Biochemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 82(3), pp.372–382.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [8] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eExperimental and Therapeutic Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 12(1), pp.513–517.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[9] Das, S.K., Masuda, M., Sakurai, A. and Sakakibara, M. (2010). Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eFitoterapia\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 81(8), pp.961–968.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[10] Ko and Leung. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[11] Gamage, S., Nakayama, J., Fuyuno, Y. and Ohga, S. (2018). The Effect of the Hot Water Extracts of the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePaecilomyces hepiali \u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003eand \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCordyceps militaris\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e Mycelia on the Growth of Gastrointestinal Bacteria. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdvances in Microbiology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 08(07), pp.490–505.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[12] Kim, S.B., Ahn, B., Kim, M., Ji, H.-J., Shin, S.-K., Hong, I.P., Kim, C.Y., Hwang, B.Y. and Lee, M.K. (2014). Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 151(1), pp.478–484.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [13] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[14] Cilerdzic, J., Stajic, M. and Vukojevic, J. (2016). Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCurrent Pharmaceutical Biotechnology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(3), pp.275–282.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[15] Wang, C.-H., Hsieh, S.-C., Wang, H.-J., Chen, M.-L., Lin, B.-F., Chiang, B.-H. and Lu, T.-J. (2014). Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 62(3), pp.634–641.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[16] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[17] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[18] Pallav, K., Dowd, S.E., Villafuerte, J., Yang, X., Kabbani, T., Hansen, J., Dennis, M., Leffler, D.A., Newburg, D.S. and Kelly, C.P. (2014). Effects of polysaccharopeptide fromTrametes Versicolorand amoxicillin on the gut microbiome of healthy volunteers. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eGut Microbes\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 5(4), pp.458–467.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[19] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePlant Foods for Human Nutrition\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 68(2), pp.107–112\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[20] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eNachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[21] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[22] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T22:45:41+11:00","sort_order":"best-selling","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-03T21:01:43+10:00","alt":"","width":2657,"height":2657,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/Reishi_Liquid_Extract.jpg?v=1561725306"}},{"id":81919148101,"handle":"our-most-popular-products","title":"Our most popular products","updated_at":"2019-11-18T23:35:01+11:00","body_html":"","published_at":"2018-10-09T20:31:53+11:00","sort_order":"manual","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-09T21:38:37+11:00","alt":"","width":1000,"height":1061,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/mushroom-box-grown_9f7cd2ae-9917-4975-be1f-7e05481b2d9d.jpg?v=1539081517"}}]$34.95 AUD