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Turkey Tail Mushroom Liquid Extract
{"id":1659981529157,"title":"Turkey Tail Mushroom Liquid Extract","handle":"turkey-tail-mushroom-liquid-extract","description":"\u003ch1\u003eTURKEY TAIL TIME \u003c\/h1\u003e\n\u003ch3\u003e\u003cstrong\u003eHonour your gut with Turkey Tail Mushroom Liquid Extract\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe Turkey Tail mushroom is an extremely abundant mushroom found predominantly in temperate forests.The mushroom has been seen in Chinese medicinal literature for centuries, used to treat a wide array of diseases. The name of the mushroom originates from its appearance, as the mushroom fruiting body resembles the fanned out tail of a turkey as it grows on decaying trees \u003ca href=\"https:\/\/www.dropbox.com\/home\/Scientific%20Litterature\/Turkey%20Tail?preview=yu2013.pdf\" target=\"_blank\" title=\"ORIGINAL PAPER Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003eThe Benefits of Turkey Tail Mushroom\u003c\/h3\u003e\n\u003cp\u003eThe bioactive compounds within the Turkey Tail Mushroom that promote beneficial physiological activities are beta-glucans, mainly polysaccharopeptide (PSP) and Polysaccharide Krestin (PSK). These beta-glucans are not readily digestible by human intestinal enzymes, however they are thought to enhance the colonisation of good bacteria within the gut which can in turn modulate the immune system and provide abundant health benefits \u003ca href=\"https:\/\/www.dropbox.com\/home\/Scientific%20Litterature\/Turkey%20Tail?preview=yu2013.pdf\" target=\"_blank\" title=\"ORIGINAL PAPER Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e, \u003ca href=\"http:\/\/citeseerx.ist.psu.edu\/viewdoc\/download?doi=10.1.1.1015.6128\u0026amp;rep=rep1\u0026amp;type=pdf\" target=\"_blank\" title=\"Gut bacteria and health foods—the European perspective\" rel=\"noopener noreferrer\"\u003e2]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eKrestin is also seen to promote the activity of leukocytes, a key agent in immune cell response \u003ca href=\"https:\/\/academic.oup.com\/nutritionreviews\/article\/67\/11\/624\/1850752\" target=\"_blank\" title=\"Beta-glucans in higher fungi and their health effects\" rel=\"noopener noreferrer\"\u003e[3\u003c\/a\u003e]. Further, the Turkey tail mushroom produces an enzyme called Laccase, which has potent antioxidative activity \u003ca href=\"https:\/\/aem.asm.org\/content\/aem\/62\/12\/4563.full.pdf\" target=\"_blank\" title=\"Oxidation of Anthracene and Benzo[a]pyrene by Laccases from Trametes versicolor\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eTo delve deeper into the world of fungi and to learn more about Turkey Tail mushrooms and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003elink \u003c\/u\u003e\u003c\/a\u003eto read our latest blogs \u003c\/p\u003e\n\u003ch3\u003eThe Use of Turkey Tail Liquid Extract\u003c\/h3\u003e\n\u003cp\u003eThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today. As is the effortless way of incorporating these mushroom extracts into your day to day life. Turkey Tail liquid extract makes the bioactive compounds within the mushroom readily available to you!\u003c\/p\u003e\n\u003cp\u003e If the Turkey Tail mushroom sounds like the perfect mushroom for you, don’t waste one more minute and buy our Turkey Tail liquid extract here today and give your tummy some love!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSome of our customers include: airplane travellers, young families, city people, prebiotic enthusiasts, balanced humans, gut focused people, partiers, seekers of immunity, talkers, walkers, workers and contributors.\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003eCustomer Feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\"As a passionate medical professional, I am constantly looking at the research to find the best health solutions for my patients. I have found both on a personal and professional level Life Cykel's Turkey Tail to not only have subjective positive outcomes but objective clinical outcomes highlighting the gut microbiome modulating effects when looking at pre \u0026amp; post intervention microbiome testing.\"\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Dr Jeremy Princi, Gut Health Specialist, Bunbury\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eLife Cykel's Turkey Tail mushrooms and extracts are grown and engineered in the Northern Rivers, NSW.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add Turkey Tail liquid double extract directly to your coffee, smoothie, tea, soup broth or water in the morning for best results.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml \u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle \u003cspan\u003e(60 day supply\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Australian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e Distilled Water, Alcohol, Australian \u003ci\u003eTrametes versicolor. \u003c\/i\u003e(\u003ci\u003eTrametes versicolor. \u003c\/i\u003eMycelial Biomass, Tra\u003ci\u003emetes versicolor. \u003c\/i\u003eFruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage: \u003c\/strong\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMushroom Research: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[1] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ePlant Foods for Human Nutrition\u003c\/i\u003e, 68(2), pp.107–112.\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[2] Saarela, M., Lähteenmäki, L., Crittenden, R., Salminen, S. and Mattila-Sandholm, T. (2002). Gut bacteria and health foods—the European perspective.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eInternational Journal of Food Microbiology\u003c\/i\u003e, 78(1–2), pp.99–117.\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[3] Rop, O., Mlcek, J. and Jurikova, T. (2009). Beta-glucans in higher fungi and their health effects.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eNutrition Reviews\u003c\/i\u003e, 67(11), pp.624–631.\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[4] Dodor, D.E., Hwang, H.-M. and Ekunwe, S.I.. (2004). Oxidation of anthracene and benzo[a]pyrene by immobilized laccase from Trametes versicolor.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eEnzyme and Microbial Technology\u003c\/i\u003e, 35(2–3), pp.210–217.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e \u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003c\/span\u003e\u003c\/p\u003e","published_at":"2019-02-25T21:57:30+11:00","created_at":"2018-10-03T12:54:56+10:00","vendor":"Life Cykel","type":"","tags":[],"price":3495,"price_min":3495,"price_max":5295,"available":true,"price_varies":true,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":31070784979004,"title":"120ml","option1":"120ml","option2":null,"option3":null,"sku":"TTDE120ml-1","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Turkey Tail Mushroom Liquid Extract - 120ml","public_title":"120ml","options":["120ml"],"price":5295,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"705632689196"},{"id":31070789632060,"title":"60ml","option1":"60ml","option2":null,"option3":null,"sku":"TTDE60ml","requires_shipping":true,"taxable":true,"featured_image":{"id":13341092184124,"product_id":1659981529157,"position":3,"created_at":"2019-10-31T15:15:57+11:00","updated_at":"2019-10-31T15:15:57+11:00","alt":null,"width":1166,"height":1500,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.turkey.60ml.png?v=1572495357","variant_ids":[31070789632060]},"available":false,"name":"Turkey Tail Mushroom Liquid Extract - 60ml","public_title":"60ml","options":["60ml"],"price":3495,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"0793591581804"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Turkey_Tail_Extract_f921761e-a2a1-4b82-8cb2-bf21878ac341.jpg?v=1564227704","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/turkey_tail.jpg?v=1564227704","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.turkey.60ml.png?v=1572495357"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Turkey_Tail_Extract_f921761e-a2a1-4b82-8cb2-bf21878ac341.jpg?v=1564227704","options":["Size"],"content":"\u003ch1\u003eTURKEY TAIL TIME \u003c\/h1\u003e\n\u003ch3\u003e\u003cstrong\u003eHonour your gut with Turkey Tail Mushroom Liquid Extract\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe Turkey Tail mushroom is an extremely abundant mushroom found predominantly in temperate forests.The mushroom has been seen in Chinese medicinal literature for centuries, used to treat a wide array of diseases. The name of the mushroom originates from its appearance, as the mushroom fruiting body resembles the fanned out tail of a turkey as it grows on decaying trees \u003ca href=\"https:\/\/www.dropbox.com\/home\/Scientific%20Litterature\/Turkey%20Tail?preview=yu2013.pdf\" target=\"_blank\" title=\"ORIGINAL PAPER Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003eThe Benefits of Turkey Tail Mushroom\u003c\/h3\u003e\n\u003cp\u003eThe bioactive compounds within the Turkey Tail Mushroom that promote beneficial physiological activities are beta-glucans, mainly polysaccharopeptide (PSP) and Polysaccharide Krestin (PSK). These beta-glucans are not readily digestible by human intestinal enzymes, however they are thought to enhance the colonisation of good bacteria within the gut which can in turn modulate the immune system and provide abundant health benefits \u003ca href=\"https:\/\/www.dropbox.com\/home\/Scientific%20Litterature\/Turkey%20Tail?preview=yu2013.pdf\" target=\"_blank\" title=\"ORIGINAL PAPER Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e, \u003ca href=\"http:\/\/citeseerx.ist.psu.edu\/viewdoc\/download?doi=10.1.1.1015.6128\u0026amp;rep=rep1\u0026amp;type=pdf\" target=\"_blank\" title=\"Gut bacteria and health foods—the European perspective\" rel=\"noopener noreferrer\"\u003e2]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eKrestin is also seen to promote the activity of leukocytes, a key agent in immune cell response \u003ca href=\"https:\/\/academic.oup.com\/nutritionreviews\/article\/67\/11\/624\/1850752\" target=\"_blank\" title=\"Beta-glucans in higher fungi and their health effects\" rel=\"noopener noreferrer\"\u003e[3\u003c\/a\u003e]. Further, the Turkey tail mushroom produces an enzyme called Laccase, which has potent antioxidative activity \u003ca href=\"https:\/\/aem.asm.org\/content\/aem\/62\/12\/4563.full.pdf\" target=\"_blank\" title=\"Oxidation of Anthracene and Benzo[a]pyrene by Laccases from Trametes versicolor\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eTo delve deeper into the world of fungi and to learn more about Turkey Tail mushrooms and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003elink \u003c\/u\u003e\u003c\/a\u003eto read our latest blogs \u003c\/p\u003e\n\u003ch3\u003eThe Use of Turkey Tail Liquid Extract\u003c\/h3\u003e\n\u003cp\u003eThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today. As is the effortless way of incorporating these mushroom extracts into your day to day life. Turkey Tail liquid extract makes the bioactive compounds within the mushroom readily available to you!\u003c\/p\u003e\n\u003cp\u003e If the Turkey Tail mushroom sounds like the perfect mushroom for you, don’t waste one more minute and buy our Turkey Tail liquid extract here today and give your tummy some love!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSome of our customers include: airplane travellers, young families, city people, prebiotic enthusiasts, balanced humans, gut focused people, partiers, seekers of immunity, talkers, walkers, workers and contributors.\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003eCustomer Feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\"As a passionate medical professional, I am constantly looking at the research to find the best health solutions for my patients. I have found both on a personal and professional level Life Cykel's Turkey Tail to not only have subjective positive outcomes but objective clinical outcomes highlighting the gut microbiome modulating effects when looking at pre \u0026amp; post intervention microbiome testing.\"\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Dr Jeremy Princi, Gut Health Specialist, Bunbury\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eLife Cykel's Turkey Tail mushrooms and extracts are grown and engineered in the Northern Rivers, NSW.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add Turkey Tail liquid double extract directly to your coffee, smoothie, tea, soup broth or water in the morning for best results.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml \u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle \u003cspan\u003e(60 day supply\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Australian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e Distilled Water, Alcohol, Australian \u003ci\u003eTrametes versicolor. \u003c\/i\u003e(\u003ci\u003eTrametes versicolor. \u003c\/i\u003eMycelial Biomass, Tra\u003ci\u003emetes versicolor. \u003c\/i\u003eFruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage: \u003c\/strong\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMushroom Research: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[1] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ePlant Foods for Human Nutrition\u003c\/i\u003e, 68(2), pp.107–112.\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[2] Saarela, M., Lähteenmäki, L., Crittenden, R., Salminen, S. and Mattila-Sandholm, T. (2002). Gut bacteria and health foods—the European perspective.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eInternational Journal of Food Microbiology\u003c\/i\u003e, 78(1–2), pp.99–117.\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[3] Rop, O., Mlcek, J. and Jurikova, T. (2009). Beta-glucans in higher fungi and their health effects.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eNutrition Reviews\u003c\/i\u003e, 67(11), pp.624–631.\u003c\/p\u003e\n\u003cp style=\"padding-left: 30px;\"\u003e[4] Dodor, D.E., Hwang, H.-M. and Ekunwe, S.I.. (2004). Oxidation of anthracene and benzo[a]pyrene by immobilized laccase from Trametes versicolor.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eEnzyme and Microbial Technology\u003c\/i\u003e, 35(2–3), pp.210–217.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e \u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003c\/span\u003e\u003c\/p\u003e"} [{"id":92048490565,"handle":"all","title":"All","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2019-02-18T10:20:43+11:00","sort_order":"best-selling","template_suffix":"","disjunctive":false,"rules":[{"column":"variant_price","relation":"greater_than","condition":"0"},{"column":"variant_inventory","relation":"greater_than","condition":"0"},{"column":"type","relation":"not_equals","condition":"Insurance"}],"published_scope":"web"},{"id":80859955269,"handle":"liquid-extracts","title":"Liquid Mushroom Extract - The Elixir of Life","updated_at":"2019-11-12T12:30:03+11:00","body_html":"\u003cp\u003eGive your body and mind proper support on your journey to vitality and longevity. Find the best organic liquid Mushroom extracts at Life Cykel today!\u003c\/p\u003e\n\u003cp\u003eFor thousands of years, traditional medicine has used mushroom tinctures as a primary means of treatment, due to the vast array of health benefits they provide. The positive outcomes and the strong faith in the power of the mushroom liquid extract, has gained them the title ”\u003cstrong\u003e\u003cem\u003eelixirs of life\u003c\/em\u003e\u003c\/strong\u003e”. These beneficial mushrooms have mainly been used in Asia \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e, but are now spreading to all corners of the world, and are being named \u003cstrong\u003e\u003cem\u003efunctional mushrooms.\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdetails\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eFunctional mushrooms are considered a superfood and are now commonly used as dietary supplements \u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09168451.2018.1431519?journalCode=tbbb20\" target=\"_blank\" title=\"Biologically functional molecules from mushroom-forming fungi. \" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003eToday, we are discovering more and more about the benefits of using these mushrooms and extensive research is being undertaken to understand the bioactive compounds within the mushrooms that provide them with such power.\u003c\/p\u003e\n\u003cp\u003e By using Life Cykel’s mushroom liquid extract, as a supplement in your everyday diet, you can effortlessly give your body and mind the proper support it requires on your mission of health and wellness.\u003c\/p\u003e\n\u003cp\u003e Life Cykel's liquid \u003cstrong\u003e\u003cem\u003edouble\u003c\/em\u003e\u003c\/strong\u003e extracts have been carefully created to be some of the most potent mushroom extracts in the world. Our extract range includes Reishi, Cordyceps, Shiitake, Lion's Mane and Turkey Tail mushrooms.\u003c\/p\u003e\n\u003cp\u003eNot only do we provide you with the best mushroom liquid extract, when producing our extracts we aim to integrate Circular Economy principles wherever possible and where available we're using Australian native mushroom strains that have been meticulously infused with Australian native, wild harvested Kakadu Plum.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/lions-mane-mushroom-liquid-extract\" title=\"Buy Lion's Mane Liquid Extract\"\u003eLion’s Mane Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eLion's Mane Mushroom is known for its positive effects on cognitive health \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24266378\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" rel=\"noopener noreferrer\"\u003e[3]\u003c\/a\u003e. This mushroom is rich in bioactive components \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26244378\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" rel=\"noopener noreferrer\"\u003e[5]\u003c\/a\u003e, which could be responsible for some important physiological activities, this includes antioxidant and anti- inflammatory activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26559695\" title=\"The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\"\u003e [6\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906890\/\" target=\"_blank\" title=\"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities\" rel=\"noopener noreferrer\"\u003e7]\u003c\/a\u003e and neural growth \u003ca href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jnatprod.6b00371?src=recsys\" target=\"_blank\" title=\"Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e, improving memory and focus as well as enhancing your dreams and mood \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31118969\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?\" rel=\"noopener noreferrer\"\u003e[8]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/cordyceps-mushroom-liquid-extract\" title=\"Buy Cordyceps Liquid Extract\"\u003eCordyceps Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eCordyceps mushroom is an extraordinary mushroom. The bioactive compounds within the mushroom, show to promote anti-inflammatory, anti-microbial and anti-oxidative activities (anti-ageing) [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=86265\" target=\"_blank\" title=\"The Effect of the Hot Water Extracts of the Paecilomyces hepiali and Cordyceps militaris Mycelia on the Growth of Gastrointestinal Bacteria\" rel=\"noopener noreferrer\"\u003e10]\u003c\/a\u003e, as well as having beneficial effects on lipid metabolism [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24231073\" target=\"_blank\" title=\"Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice.\" rel=\"noopener noreferrer\"\u003e11]\u003c\/a\u003e and may improve your endurance to prolonged and high intensity exercise \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e[9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5236007\/\" target=\"_blank\" title=\"Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation\" rel=\"noopener noreferrer\"\u003e12\u003c\/a\u003e,\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28094746\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming.\" rel=\"noopener noreferrer\"\u003e13\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/reishi-mushroom-liquid-extract\" title=\"Buy Reishi Liquid Extract\"\u003eReishi Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eFor many millennia the Reishi mushroom has been used to treat a variety of diseases, including cardiovascular diseases and insomnia \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e[14]\u003c\/a\u003e. The constituents within the mushroom may help to enhance anti-microbial, anti-oxidant and immunomodulating activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e [14\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ingentaconnect.com\/contentone\/ben\/cpb\/2016\/00000017\/00000003\/art00010\" target=\"_blank\" title=\"Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents\" rel=\"noopener noreferrer\"\u003e15\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24386913\" target=\"_blank\" title=\"Concentration variation and molecular characteristics of soluble (1,3;1,6)-β-D-glucans in submerged cultivation products of Ganoderma lucidum mycelium\" rel=\"noopener noreferrer\"\u003e16\u003c\/a\u003e]. The mushroom is also well known for its beneficial effects on sleep and relaxation [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e17\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Extract+of+Ganoderma+lucidum+prolongs+sleep+time+in+rats\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats\" rel=\"noopener noreferrer\"\u003e18\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/turkey-tail-mushroom-liquid-extract\" title=\"Buy Turkey Tail Liquid Extract\"\u003eTurkey Tail Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eThe Turkey Tail mushroom is mainly consumed to regulate the immune system. However, more recent research is also showing evidence that the mushroom may have the ability of modulating the composition of the human microbiome [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25006989\" target=\"_blank\" title=\"Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial\" rel=\"noopener noreferrer\"\u003e19\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23435630\" target=\"_blank\" title=\"Trametes versicolor extract modifies human fecal microbiota composition in vitro.\" rel=\"noopener noreferrer\"\u003e20]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/shiitake-mushroom-liquid-extract\" title=\"Buy Shiitake Liquid Extract\"\u003eShiitake mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eShiitake mushrooms have been utilised for their anti-sclerotic (reduce hardening of arteries) activities as well as helping to reduce damage from UV light and helping to increase the renewal process of the skin, therefore this mushroom could be considered as an effective anti-photoaging and skin care ingredient \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\"L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e[21,\u003c\/a\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\"l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study\" rel=\"noopener noreferrer\"\u003e 22,\u003c\/a\u003e \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e23]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eLearn more about our mushrooms by browsing our range of liquid mushroom extracts below or click \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003ehere\u003c\/u\u003e\u003c\/a\u003e to read our latest blogs on these fantastic fungi!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2] Choi, J.-H. (2018). Biologically functional molecules from mushroom-forming fungi. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eBioscience, Biotechnology, and Biochemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 82(3), pp.372–382.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [8] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eExperimental and Therapeutic Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 12(1), pp.513–517.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[9] Das, S.K., Masuda, M., Sakurai, A. and Sakakibara, M. (2010). Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eFitoterapia\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 81(8), pp.961–968.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[10] Ko and Leung. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[11] Gamage, S., Nakayama, J., Fuyuno, Y. and Ohga, S. (2018). The Effect of the Hot Water Extracts of the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePaecilomyces hepiali \u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003eand \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCordyceps militaris\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e Mycelia on the Growth of Gastrointestinal Bacteria. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdvances in Microbiology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 08(07), pp.490–505.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[12] Kim, S.B., Ahn, B., Kim, M., Ji, H.-J., Shin, S.-K., Hong, I.P., Kim, C.Y., Hwang, B.Y. and Lee, M.K. (2014). Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 151(1), pp.478–484.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [13] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[14] Cilerdzic, J., Stajic, M. and Vukojevic, J. (2016). Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCurrent Pharmaceutical Biotechnology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(3), pp.275–282.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[15] Wang, C.-H., Hsieh, S.-C., Wang, H.-J., Chen, M.-L., Lin, B.-F., Chiang, B.-H. and Lu, T.-J. (2014). Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 62(3), pp.634–641.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[16] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[17] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[18] Pallav, K., Dowd, S.E., Villafuerte, J., Yang, X., Kabbani, T., Hansen, J., Dennis, M., Leffler, D.A., Newburg, D.S. and Kelly, C.P. (2014). Effects of polysaccharopeptide fromTrametes Versicolorand amoxicillin on the gut microbiome of healthy volunteers. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eGut Microbes\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 5(4), pp.458–467.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[19] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePlant Foods for Human Nutrition\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 68(2), pp.107–112\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[20] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eNachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[21] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[22] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T22:45:41+11:00","sort_order":"best-selling","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-03T21:01:43+10:00","alt":"","width":2657,"height":2657,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/Reishi_Liquid_Extract.jpg?v=1561725306"}},{"id":81919148101,"handle":"our-most-popular-products","title":"Our most popular products","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2018-10-09T20:31:53+11:00","sort_order":"manual","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-09T21:38:37+11:00","alt":"","width":1000,"height":1061,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/mushroom-box-grown_9f7cd2ae-9917-4975-be1f-7e05481b2d9d.jpg?v=1539081517"}}]$34.95 AUD
Reishi Mushroom Liquid Extract
{"id":1661912842309,"title":"Reishi Mushroom Liquid Extract","handle":"reishi-mushroom-liquid-extract","description":"\u003ch1\u003eThe Mushroom of Immortality\u003c\/h1\u003e\n\u003cp\u003eThe Reishi mushroom is a red woody fungus that tends to grow predominantly on hardwoods. The mushroom is commonly known as the mushroom of immortality, as it has been used for many millennia in Chinese medicine to various diseases such as cardiovascular diseases and insomnia [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e, \u003ca href=\"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.6b00973\" target=\"_blank\" title=\"Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids\" rel=\"noopener noreferrer\"\u003e2]\u003c\/a\u003e. In China the Reishi mushroom is regarded as a symbol of health, longevity, success and divine power [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch2\u003eThe Use of Reishi Liquid Extract\u003c\/h2\u003e\n\u003cp\u003eUnlike some of the Reishi mushroom’s counterparts such as Lion’s mane or Shiitake mushroom, it is not famous for its edibility and taste but rather its pharmaceutical properties [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e]. That is why it is commonly taken as a liquid extract.\u003c\/p\u003e\n\u003cp\u003eThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today. As is the effortless way of incorporating these mushroom extracts into your day to day life. This Reishi mushroom liquid extract makes the bioactive compounds within the mushroom readily available to you, so you can take it easy.\u003c\/p\u003e\n\u003ch3\u003eThe Benefits of Reishi Mushroom\u003c\/h3\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eThe bioactive constituents that have been found to hold medicinal properties within the Reishi mushroom are mainly Lanostane-type triterpinoids and polysaccharides such as beta-glucans. These are considered as potent agents for enhancing the immune system, as well as having high antioxidant and anti-microbial capacities [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e, \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,5d7e3270003d02bf,6a2db231456631ee.html\" target=\"_blank\" title=\"Antibacterial and Antiviral Value of the Genus Ganoderma P. Karst. Species (Aphyllophoromycetideae): A Review\" rel=\"noopener noreferrer\"\u003e3\u003c\/a\u003e].\u003c\/p\u003e\n\u003cp\u003eThe mushroom is also well known for its beneficial effects on sleep and relaxation. When consumed, the mushroom shows to have hypnotic\/sedative type effects, which can decrease sleep latency (time taken to fall asleep) and may increase overall sleeping time, which explains why the mushroom has also been used to treat restlessness, palpitation and insomnia in China for hundreds of years [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e4\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22207209\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats.\" rel=\"noopener noreferrer\"\u003e5]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eTo delve deeper into the world of fungi and to learn more about Reishi mushroom and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003elink \u003c\/u\u003e\u003c\/a\u003eto read our latest blogs . . . . . .\u003c\/p\u003e\n\u003ch4\u003eYour Reishi Liquid Double Extract\u003c\/h4\u003e\n\u003cp\u003eConsumption of Reishi mushroom is increasing all over the world, as many people want to tap into the benefits of this all giving mushroom. That’s why Life Cykel are bringing to you our Reishi mushroom liquid extract so you can relax with Reishi.\u003c\/p\u003e\n\u003cp\u003eAre you interested to buy Reishi Mushroom extract? Then go no further, buy Reishi mushroom liquid extract here, one of Australia’s most unique products!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSome of our customers include: chillers, relaxers, deep breathers, meditators, yoga and Pilates practitioners, mystics, bohemians, surfers, channelers, people in flow, gardeners, kind people, missionaries and musicians.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCustomer Feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e“I travel to the city a lot and always take my Reishi with me. It adds a sense of calmness to my life when immersed in a modern busy lifestyle. It helps me manage stress.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Emma, Nurse, Byron Bay\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add Reishi liquid double extract directly to your coffee, smoothie, tea, soup broth or water in the evening for best results.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml \u003c\/p\u003e\n\u003cp\u003eLife Cykel’s Reishi mushroom liquid extracts are engineered in the Northern Rivers, NSW.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle \u003cspan\u003e(60 day supply\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003eOriginally harvested in the USA\u003c\/li\u003e\n\u003cli\u003eAustralian sourced ingredients\u003c\/li\u003e\n\u003cli\u003eGluten free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e:\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eDistilled Water, Organic Alcohol,\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eGanoderma lucidium.\u003c\/em\u003e \u003c\/span\u003e\u003cspan\u003e(\u003c\/span\u003e\u003cspan\u003eG\u003cem\u003eanoderma lucidium.\u003c\/em\u003e\u003c\/span\u003e\u003cspan\u003e Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eGanoderma lucidium.\u003c\/em\u003e\u003c\/span\u003e\u003cspan\u003e Fruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eStorage\u003cstrong\u003e: \u003c\/strong\u003e\u003c\/b\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cspan style=\"font-weight: 400;\"\u003eReferences\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Sissi WG, John Y, John AB, Iris FFB. Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Herbal Medicine: Biomolecular and Clinical\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [2] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Wachtel-Galor S, Yuen J, Buswell JA, et al. (2011) Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press\/Taylor \u0026amp; Francis; 2011. Chapter 9.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Gao, Y; Zhou, S; Huang, M; Xu, A (2013). Antibacterial and antiviral value of the genus Ganoderma P. Karst. species (aphyllophoromycetideae): A review. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, [online] 5(3), pp.235–246. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[8] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003col start=\"2\"\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e* This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e* This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T21:45:52+11:00","created_at":"2018-10-03T20:23:12+10:00","vendor":"Life Cykel","type":"","tags":[],"price":3495,"price_min":3495,"price_max":5295,"available":true,"price_varies":true,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":31070766268476,"title":"120ml","option1":"120ml","option2":null,"option3":null,"sku":"RDE120ml-1","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Reishi Mushroom Liquid Extract - 120ml","public_title":"120ml","options":["120ml"],"price":5295,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"705632689127"},{"id":31070774263868,"title":"60ml","option1":"60ml","option2":null,"option3":null,"sku":"RDE60ml","requires_shipping":true,"taxable":true,"featured_image":{"id":13341065642044,"product_id":1661912842309,"position":3,"created_at":"2019-10-31T15:10:58+11:00","updated_at":"2019-10-31T15:10:58+11:00","alt":null,"width":1033,"height":1500,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.reishi.60ml.png?v=1572495058","variant_ids":[31070774263868]},"available":false,"name":"Reishi Mushroom Liquid Extract - 60ml","public_title":"60ml","options":["60ml"],"price":3495,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"0793591711201"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Reishi_Extract_cfa122b4-be2c-45b8-b1ce-581e7cab0edc.jpg?v=1564227663","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Reishi_s.jpg?v=1564227663","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.reishi.60ml.png?v=1572495058"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Reishi_Extract_cfa122b4-be2c-45b8-b1ce-581e7cab0edc.jpg?v=1564227663","options":["Size"],"content":"\u003ch1\u003eThe Mushroom of Immortality\u003c\/h1\u003e\n\u003cp\u003eThe Reishi mushroom is a red woody fungus that tends to grow predominantly on hardwoods. The mushroom is commonly known as the mushroom of immortality, as it has been used for many millennia in Chinese medicine to various diseases such as cardiovascular diseases and insomnia [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e, \u003ca href=\"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.6b00973\" target=\"_blank\" title=\"Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids\" rel=\"noopener noreferrer\"\u003e2]\u003c\/a\u003e. In China the Reishi mushroom is regarded as a symbol of health, longevity, success and divine power [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch2\u003eThe Use of Reishi Liquid Extract\u003c\/h2\u003e\n\u003cp\u003eUnlike some of the Reishi mushroom’s counterparts such as Lion’s mane or Shiitake mushroom, it is not famous for its edibility and taste but rather its pharmaceutical properties [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e]. That is why it is commonly taken as a liquid extract.\u003c\/p\u003e\n\u003cp\u003eThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today. As is the effortless way of incorporating these mushroom extracts into your day to day life. This Reishi mushroom liquid extract makes the bioactive compounds within the mushroom readily available to you, so you can take it easy.\u003c\/p\u003e\n\u003ch3\u003eThe Benefits of Reishi Mushroom\u003c\/h3\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eThe bioactive constituents that have been found to hold medicinal properties within the Reishi mushroom are mainly Lanostane-type triterpinoids and polysaccharides such as beta-glucans. These are considered as potent agents for enhancing the immune system, as well as having high antioxidant and anti-microbial capacities [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e, \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,5d7e3270003d02bf,6a2db231456631ee.html\" target=\"_blank\" title=\"Antibacterial and Antiviral Value of the Genus Ganoderma P. Karst. Species (Aphyllophoromycetideae): A Review\" rel=\"noopener noreferrer\"\u003e3\u003c\/a\u003e].\u003c\/p\u003e\n\u003cp\u003eThe mushroom is also well known for its beneficial effects on sleep and relaxation. When consumed, the mushroom shows to have hypnotic\/sedative type effects, which can decrease sleep latency (time taken to fall asleep) and may increase overall sleeping time, which explains why the mushroom has also been used to treat restlessness, palpitation and insomnia in China for hundreds of years [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e4\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22207209\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats.\" rel=\"noopener noreferrer\"\u003e5]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eTo delve deeper into the world of fungi and to learn more about Reishi mushroom and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003elink \u003c\/u\u003e\u003c\/a\u003eto read our latest blogs . . . . . .\u003c\/p\u003e\n\u003ch4\u003eYour Reishi Liquid Double Extract\u003c\/h4\u003e\n\u003cp\u003eConsumption of Reishi mushroom is increasing all over the world, as many people want to tap into the benefits of this all giving mushroom. That’s why Life Cykel are bringing to you our Reishi mushroom liquid extract so you can relax with Reishi.\u003c\/p\u003e\n\u003cp\u003eAre you interested to buy Reishi Mushroom extract? Then go no further, buy Reishi mushroom liquid extract here, one of Australia’s most unique products!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSome of our customers include: chillers, relaxers, deep breathers, meditators, yoga and Pilates practitioners, mystics, bohemians, surfers, channelers, people in flow, gardeners, kind people, missionaries and musicians.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCustomer Feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e“I travel to the city a lot and always take my Reishi with me. It adds a sense of calmness to my life when immersed in a modern busy lifestyle. It helps me manage stress.”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Emma, Nurse, Byron Bay\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add Reishi liquid double extract directly to your coffee, smoothie, tea, soup broth or water in the evening for best results.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml \u003c\/p\u003e\n\u003cp\u003eLife Cykel’s Reishi mushroom liquid extracts are engineered in the Northern Rivers, NSW.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle \u003cspan\u003e(60 day supply\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003eOriginally harvested in the USA\u003c\/li\u003e\n\u003cli\u003eAustralian sourced ingredients\u003c\/li\u003e\n\u003cli\u003eGluten free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e:\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eDistilled Water, Organic Alcohol,\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eGanoderma lucidium.\u003c\/em\u003e \u003c\/span\u003e\u003cspan\u003e(\u003c\/span\u003e\u003cspan\u003eG\u003cem\u003eanoderma lucidium.\u003c\/em\u003e\u003c\/span\u003e\u003cspan\u003e Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eGanoderma lucidium.\u003c\/em\u003e\u003c\/span\u003e\u003cspan\u003e Fruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eStorage\u003cstrong\u003e: \u003c\/strong\u003e\u003c\/b\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cspan style=\"font-weight: 400;\"\u003eReferences\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Sissi WG, John Y, John AB, Iris FFB. Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Herbal Medicine: Biomolecular and Clinical\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [2] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Wachtel-Galor S, Yuen J, Buswell JA, et al. (2011) Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press\/Taylor \u0026amp; Francis; 2011. Chapter 9.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Gao, Y; Zhou, S; Huang, M; Xu, A (2013). Antibacterial and antiviral value of the genus Ganoderma P. Karst. species (aphyllophoromycetideae): A review. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, [online] 5(3), pp.235–246. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[8] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003col start=\"2\"\u003e\u003c\/ol\u003e\n\u003cp\u003e \u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e* This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e* This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/details\u003e"} [{"id":92048490565,"handle":"all","title":"All","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2019-02-18T10:20:43+11:00","sort_order":"best-selling","template_suffix":"","disjunctive":false,"rules":[{"column":"variant_price","relation":"greater_than","condition":"0"},{"column":"variant_inventory","relation":"greater_than","condition":"0"},{"column":"type","relation":"not_equals","condition":"Insurance"}],"published_scope":"web"},{"id":80859955269,"handle":"liquid-extracts","title":"Liquid Mushroom Extract - The Elixir of Life","updated_at":"2019-11-12T12:30:03+11:00","body_html":"\u003cp\u003eGive your body and mind proper support on your journey to vitality and longevity. Find the best organic liquid Mushroom extracts at Life Cykel today!\u003c\/p\u003e\n\u003cp\u003eFor thousands of years, traditional medicine has used mushroom tinctures as a primary means of treatment, due to the vast array of health benefits they provide. The positive outcomes and the strong faith in the power of the mushroom liquid extract, has gained them the title ”\u003cstrong\u003e\u003cem\u003eelixirs of life\u003c\/em\u003e\u003c\/strong\u003e”. These beneficial mushrooms have mainly been used in Asia \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e, but are now spreading to all corners of the world, and are being named \u003cstrong\u003e\u003cem\u003efunctional mushrooms.\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdetails\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eFunctional mushrooms are considered a superfood and are now commonly used as dietary supplements \u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09168451.2018.1431519?journalCode=tbbb20\" target=\"_blank\" title=\"Biologically functional molecules from mushroom-forming fungi. \" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003eToday, we are discovering more and more about the benefits of using these mushrooms and extensive research is being undertaken to understand the bioactive compounds within the mushrooms that provide them with such power.\u003c\/p\u003e\n\u003cp\u003e By using Life Cykel’s mushroom liquid extract, as a supplement in your everyday diet, you can effortlessly give your body and mind the proper support it requires on your mission of health and wellness.\u003c\/p\u003e\n\u003cp\u003e Life Cykel's liquid \u003cstrong\u003e\u003cem\u003edouble\u003c\/em\u003e\u003c\/strong\u003e extracts have been carefully created to be some of the most potent mushroom extracts in the world. Our extract range includes Reishi, Cordyceps, Shiitake, Lion's Mane and Turkey Tail mushrooms.\u003c\/p\u003e\n\u003cp\u003eNot only do we provide you with the best mushroom liquid extract, when producing our extracts we aim to integrate Circular Economy principles wherever possible and where available we're using Australian native mushroom strains that have been meticulously infused with Australian native, wild harvested Kakadu Plum.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/lions-mane-mushroom-liquid-extract\" title=\"Buy Lion's Mane Liquid Extract\"\u003eLion’s Mane Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eLion's Mane Mushroom is known for its positive effects on cognitive health \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24266378\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" rel=\"noopener noreferrer\"\u003e[3]\u003c\/a\u003e. This mushroom is rich in bioactive components \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26244378\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" rel=\"noopener noreferrer\"\u003e[5]\u003c\/a\u003e, which could be responsible for some important physiological activities, this includes antioxidant and anti- inflammatory activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26559695\" title=\"The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\"\u003e [6\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906890\/\" target=\"_blank\" title=\"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities\" rel=\"noopener noreferrer\"\u003e7]\u003c\/a\u003e and neural growth \u003ca href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jnatprod.6b00371?src=recsys\" target=\"_blank\" title=\"Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e, improving memory and focus as well as enhancing your dreams and mood \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31118969\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?\" rel=\"noopener noreferrer\"\u003e[8]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/cordyceps-mushroom-liquid-extract\" title=\"Buy Cordyceps Liquid Extract\"\u003eCordyceps Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eCordyceps mushroom is an extraordinary mushroom. The bioactive compounds within the mushroom, show to promote anti-inflammatory, anti-microbial and anti-oxidative activities (anti-ageing) [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=86265\" target=\"_blank\" title=\"The Effect of the Hot Water Extracts of the Paecilomyces hepiali and Cordyceps militaris Mycelia on the Growth of Gastrointestinal Bacteria\" rel=\"noopener noreferrer\"\u003e10]\u003c\/a\u003e, as well as having beneficial effects on lipid metabolism [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24231073\" target=\"_blank\" title=\"Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice.\" rel=\"noopener noreferrer\"\u003e11]\u003c\/a\u003e and may improve your endurance to prolonged and high intensity exercise \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e[9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5236007\/\" target=\"_blank\" title=\"Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation\" rel=\"noopener noreferrer\"\u003e12\u003c\/a\u003e,\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28094746\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming.\" rel=\"noopener noreferrer\"\u003e13\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/reishi-mushroom-liquid-extract\" title=\"Buy Reishi Liquid Extract\"\u003eReishi Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eFor many millennia the Reishi mushroom has been used to treat a variety of diseases, including cardiovascular diseases and insomnia \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e[14]\u003c\/a\u003e. The constituents within the mushroom may help to enhance anti-microbial, anti-oxidant and immunomodulating activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e [14\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ingentaconnect.com\/contentone\/ben\/cpb\/2016\/00000017\/00000003\/art00010\" target=\"_blank\" title=\"Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents\" rel=\"noopener noreferrer\"\u003e15\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24386913\" target=\"_blank\" title=\"Concentration variation and molecular characteristics of soluble (1,3;1,6)-β-D-glucans in submerged cultivation products of Ganoderma lucidum mycelium\" rel=\"noopener noreferrer\"\u003e16\u003c\/a\u003e]. The mushroom is also well known for its beneficial effects on sleep and relaxation [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e17\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Extract+of+Ganoderma+lucidum+prolongs+sleep+time+in+rats\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats\" rel=\"noopener noreferrer\"\u003e18\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/turkey-tail-mushroom-liquid-extract\" title=\"Buy Turkey Tail Liquid Extract\"\u003eTurkey Tail Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eThe Turkey Tail mushroom is mainly consumed to regulate the immune system. However, more recent research is also showing evidence that the mushroom may have the ability of modulating the composition of the human microbiome [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25006989\" target=\"_blank\" title=\"Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial\" rel=\"noopener noreferrer\"\u003e19\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23435630\" target=\"_blank\" title=\"Trametes versicolor extract modifies human fecal microbiota composition in vitro.\" rel=\"noopener noreferrer\"\u003e20]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/shiitake-mushroom-liquid-extract\" title=\"Buy Shiitake Liquid Extract\"\u003eShiitake mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eShiitake mushrooms have been utilised for their anti-sclerotic (reduce hardening of arteries) activities as well as helping to reduce damage from UV light and helping to increase the renewal process of the skin, therefore this mushroom could be considered as an effective anti-photoaging and skin care ingredient \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\"L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e[21,\u003c\/a\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\"l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study\" rel=\"noopener noreferrer\"\u003e 22,\u003c\/a\u003e \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e23]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eLearn more about our mushrooms by browsing our range of liquid mushroom extracts below or click \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003ehere\u003c\/u\u003e\u003c\/a\u003e to read our latest blogs on these fantastic fungi!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2] Choi, J.-H. (2018). Biologically functional molecules from mushroom-forming fungi. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eBioscience, Biotechnology, and Biochemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 82(3), pp.372–382.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [8] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eExperimental and Therapeutic Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 12(1), pp.513–517.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[9] Das, S.K., Masuda, M., Sakurai, A. and Sakakibara, M. (2010). Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eFitoterapia\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 81(8), pp.961–968.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[10] Ko and Leung. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[11] Gamage, S., Nakayama, J., Fuyuno, Y. and Ohga, S. (2018). The Effect of the Hot Water Extracts of the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePaecilomyces hepiali \u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003eand \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCordyceps militaris\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e Mycelia on the Growth of Gastrointestinal Bacteria. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdvances in Microbiology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 08(07), pp.490–505.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[12] Kim, S.B., Ahn, B., Kim, M., Ji, H.-J., Shin, S.-K., Hong, I.P., Kim, C.Y., Hwang, B.Y. and Lee, M.K. (2014). Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 151(1), pp.478–484.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [13] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[14] Cilerdzic, J., Stajic, M. and Vukojevic, J. (2016). Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCurrent Pharmaceutical Biotechnology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(3), pp.275–282.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[15] Wang, C.-H., Hsieh, S.-C., Wang, H.-J., Chen, M.-L., Lin, B.-F., Chiang, B.-H. and Lu, T.-J. (2014). Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 62(3), pp.634–641.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[16] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[17] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[18] Pallav, K., Dowd, S.E., Villafuerte, J., Yang, X., Kabbani, T., Hansen, J., Dennis, M., Leffler, D.A., Newburg, D.S. and Kelly, C.P. (2014). Effects of polysaccharopeptide fromTrametes Versicolorand amoxicillin on the gut microbiome of healthy volunteers. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eGut Microbes\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 5(4), pp.458–467.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[19] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePlant Foods for Human Nutrition\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 68(2), pp.107–112\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[20] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eNachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[21] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[22] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T22:45:41+11:00","sort_order":"best-selling","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-03T21:01:43+10:00","alt":"","width":2657,"height":2657,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/Reishi_Liquid_Extract.jpg?v=1561725306"}},{"id":81919148101,"handle":"our-most-popular-products","title":"Our most popular products","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2018-10-09T20:31:53+11:00","sort_order":"manual","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-09T21:38:37+11:00","alt":"","width":1000,"height":1061,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/mushroom-box-grown_9f7cd2ae-9917-4975-be1f-7e05481b2d9d.jpg?v=1539081517"}}]$34.95 AUD
Shiitake Mushroom Liquid Extract
{"id":1662038736965,"title":"Shiitake Mushroom Liquid Extract","handle":"shiitake-mushroom-liquid-extract","description":"\u003ch2\u003e\u003cstrong\u003eHOLY SHIITAKE\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eConnect to your inner radiance with Life Cykel’s Shiitake Mushroom Extract.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Shiitake mushroom is ranked number 2 in the global mushroom market, for its delicious taste as well as its array of health and beauty benefits \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"entinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e. This mushroom has been utilised as an edible and medicinal mushroom in Asia for many years thanks to its immune regulating and anti-ageing actions \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21598414\" target=\"_blank\" title=\"Efficacy and safety of orally administered Lentinula edodes mycelia extract for patients undergoing cancer chemotherapy: a pilot study.\" rel=\"noopener noreferrer\"\u003e[2].\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eThe Benefits of Shiitake Mushroom\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eThere are many bioactive compounds within the Shiitake mushroom, including the polysaccharide, lentinan, which is shown to increase the activity of the immune system \u003ca href=\"https:\/\/nutritionj.biomedcentral.com\/articles\/10.1186\/1475-2891-13-35\" target=\"_blank\" title=\"Dietary supplementation with rice bran fermented with Lentinus edodesincreases interferon-γ activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study\" rel=\"noopener noreferrer\"\u003e[3].\u003c\/a\u003e Further, beta-gluans and ergosterols found within the mushroom have also been seen to prevent sclerosis (the hardening of arteries), which in turn may support a healthy cardiovascular system \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"entinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e The Shiitake mushroom also works wonders for our skin and hair. The mushroom contains large quantities of the amino acid l-Ergothioneine, which helps to reduce damage from UV light\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\" Article (PDF Available) · March 2014 with 142 Reads DOI: 10.3390\/cosmetics1010051 Cite this publication Karolina Bazela 24.13Dr. Irena Eris Aleksandra Solyga-Zurek + 2 Renata Monika Debowska 23.08Independent Researcher Katarzyna Rogiewicz Show more authors Abstract Many changes related to aging at the cellular level may be due to the physiological condition of mitochondria. One of the most common types of damage of mtDNA is the so-called “common deletion” referring to a deletion of 4977 base pairs. In the skin cells this phenomenon probably is caused by oxidative damage of mtDNA induced by UV. The present study was aimed at evaluating the effect of the antioxidant l-ergothioneine on UV-induced damage in skin cells. The effect of l-ergothioneine on the reduced glutathione level was studied. The presence of the “common deletion” in human fibroblasts irradiated with UVA and treated with l-ergothioneine was evaluated by a polymerase chain reaction. We have demonstrated that l-ergothioneine enhanced the level of reduced glutathione and protected cells from the induction of a photoaging-associated mtDNA “common deletion”. In view of our results, l-ergothioneine could be an effective skin care and anti-photoaging ingredient. Discover the world's research 15+ million members 118+ million publications 700k+ research projects Join for free Figures - available via license: CC BY 4.0 Content may be subject to copyright. Chemical structure of L-ergothioneine. Chemical structure of L-ergothioneine. … . PCR primers for detection of the \u0026quot;common deletion\u0026quot; in mtDNA. . PCR primers for detection of the \u0026quot;common deletion\u0026quot; in mtDNA. … . . … +1 No caption available … Available via license: CC BY 4.0 Content may be subject to copyright. Download full-text PDF Cosmetics 2014, 1, 51-60; doi:10.3390\/cosmetics1010051 cosmetics ISSN 2079-9284 www.mdpi.com\/journal\/cosmetics Communication L-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study Karolina Bazela 1,†,*, Aleksandra Solyga-Zurek 2,†, Renata Debowska 1, Katarzyna Rogiewicz 1, Ewa Bartnik 2 and Irena Eris 1 1 Dr. Irena Eris Cosmetic Laboratories, Centre for Science and Research, Pulawska 107a, Warsaw 02-595, Poland; E-Mails: renata.debowska@eris.pl (R.D.); katarzyna.rogiewicz@eris.pl (K.R.); irena.eris@eris.pl (I.E.) 2 Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, Warsaw 02-106, Poland; E-Mails: asolyga@biol.uw.edu.pl (A.S.-Z.); ebartnik@igib.uw.edu.pl (E.B.) † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: karolina.bazela@eris.pl; Tel.: +48-22-717-1248; Fax: +48-22-757-0612. Received: 31 December 2013; in revised form: 10 March 2014 \/ Accepted: 11 March 2014 \/ Published: 20 March 2014 Abstract: Many changes related to aging at the cellular level may be due to the physiological condition of mitochondria. One of the most common types of damage of mtDNA is the so-called “common deletion” referring to a deletion of 4977 base pairs. In the skin cells this phenomenon probably is caused by oxidative damage of mtDNA induced by UV. The present study was aimed at evaluating the effect of the antioxidant L-ergothioneine on UV-induced damage in skin cells. The effect of L-ergothioneine on the reduced glutathione level was studied. The presence of the “common deletion” in human fibroblasts irradiated with UVA and treated with L-ergothioneine was evaluated by a polymerase chain reaction. We have demonstrated that L-ergothioneine enhanced the level of reduced glutathione and protected cells from the induction of a photoaging-associated mtDNA “common deletion”. In view of our results, L-ergothioneine could be an effective skin care and anti-photoaging ingredient. Keywords: L-ergothioneine; common deletion; mitochondria; photoaging OPEN ACCESS Cosmetics 2014, 1 52 1. Introduction Ultraviolet irradiation is one of the most important environmental factors in the development of a number of skin conditions, ranging from photoaging to cancer. UVA\/B rays penetrate into the skin, reach cells and are absorbed by proteins, lipids, and nuclear and mitochondrial DNA, causing a cascade of oxidative events that can result in progressive deterioration of cellular structure and function [1–3]. There are many theories of aging and a number of them encompass the role of mitochondria in this process. Mitochondria are responsible for producing approximately 90% of the cellular energy in the process of oxidative phosphorylation where electrons from NADH and FADH2 are transferred to oxygen. This generates a significant amount of reactive oxygen species (ROS). Mitochondria are able to counteract the production of ROS with antioxidant defense systems which can detoxify the amount of ROS produced, however, some ROS do evade these processes and are able to damage mitochondrial DNA (mtDNA) as well as proteins and lipids. Mitochondria contain their own DNA (mtDNA), which is distinct from nuclear DNA and more susceptible to damage. Mitochondrial DNA mutations and deletions have been shown to accumulate in many tissues in mammals during aging. mtDNA mutations are thought to arise due to the close proximity to the inner membrane where reactive oxygen species are continually produced in the electron transport chain. This, along with the absence of protective histones and impaired DNA photoproduct repair makes mtDNA a sensitive marker of UV-induced DNA damage [4,5]. It has been shown that photoaged skin is characterized by increased mutations in the mitochondrial (mt) genome [6]. The most frequently reported deletion is a large-scale (4977 bp) deletion also called the “common deletion” (CD). In human skin CD has been shown to occur more frequently with increasing sun exposure and thus appears to be a useful marker rather for UVA induced alterations than for chronological aging [7–10]. The use of antioxidants is an effective approach to prevent symptoms related to photo-induced aging of the skin. Many antioxidants have long been used in cosmetology. L-Ergothioneine (EGT) is an unusual sulphur-containing derivative of an amino acid, histidine, which is acquired by mammals exclusively in their diet. L-Ergothioneine has two functional groups: L-thiol (SH) group and quaternary ammonium group N–(CH3)3 (Figure 1). EGT’s thiol group implies an antioxidant role. The quaternary group EGT resembles carnitine and transfers fatty acids into the mitochondria, therefore increasing the ATP level in cells. EGT is concentrated in cells and tissues frequently exposed to oxidative stress. Numerous in vitro assays have demonstrated the antioxidant and cytoprotective capabilities of EGT against a wide range of cellular stressors [11–13]. Figure 1. Chemical structure of L-ergothioneine. Cosmetics 2014, 1 53 On the basis of these data on the antioxidant activity of L-ergothioneine we found it interesting to study the effect of this substance on UV-induced alterations in skin cell cultures, particularly on mtDNA damage. 2. Experimental Section 2.1. Cell Cultures KB cells (epidermoid carcinoma cell line KB, American Type Culture Collection (ATCC), Manassas, VA, USA) were grown in standard RPMI medium (Invitrogen, Carlsbad, CA, USA), supplemented with 10% fetal calf serum, 2 mM L-glutamine and antibiotics (100 U\/mL penicillin, 0.25 µg\/mL streptomycin sulfate) at 37 °C in 5% CO2. The KB cell line was used as a model representing human keratinocytes. Skin samples, obtained from donors undergoing cosmetic surgery, were treated with dispase II solution (5 mg\/mL, Sigma-Aldrich, St. Louis, MO, USA) at 4 °C for 16 h, followed by separation of dermal and epidermal layers with tweezers. Next, the dermis was cut into ~1 mm2 fragments and treated with 2 mg\/mL collagenase and 0.1 mg\/mL DNase (Sigma-Aldrich, St. Louis, MO, USA) overnight. Liberated cells were seeded into cell culture flasks for culture. Primary human fibroblasts were grown in standard DMEM medium (Invitrogen, Carlsbad, CA, USA), supplemented with 10% fetal calf serum (Invitrogen, Carlsbad, CA, USA), 10 mM HEPES, 2 mM L-glutamine and antibiotics (100 U\/mL penicillin, 0.25 µg\/mL streptomycin sulfate) and 50 µg\/mL uridine, with or without 20 µM L-ergothioneine (Barnet Products Corp.,Englewood Cliffs, NJ, USA), at 37 °C in 5% CO2. Confluent passages between 2 and 8 were used. 2.2. UVB Irradiation Confluent KB cells (control and treated with 20 µM L-ergothioneine (Barnet Products Corp., Englewood Cliffs, NJ, USA)) were exposed to UVB (300 J\/m2, fluorescent bulb TL12 Philips, emission peak at 313 nm) through phosphate buffered saline. 2.3. UVA Irradiation The presence of the “common deletion” was evaluated in fibroblasts derived from 2 female donors aged 38 and 45 and from 2 male donors aged 30 and 42. Cells were grown in the presence of 50 µg\/mL uridine (Sigma-Aldrich, St. Louis, MO, USA), with or without 20 µM L-ergothioneine and irradiated with 3 doses (8 J\/cm2, fluorescent bulb GE F4T5\/BLB, emission peak at 368 nm) of UVA per day, through phosphate buffered saline. This procedure was repeated for 4 consecutive days during 3 weeks. 2.4. Colorimetric Determination of Reduced Glutathione (GSH) GSH level was measured using the GSH\/GSSG-412 assay (OxisResearchTM, Portland, OR, USA)—colorimetric determination of reduced and oxidized glutathione. The method employs Ellmanʼs reagent (5,5'-dithiobis-2-nitrobenzoic acid—DTNB), which reacts with GSH to form a product which is spectrophotometrically detectable at 412 nm. The change in absorbance at 412 nm is Cosmetics 2014, 1 54 a linear function of the GSH concentration in the reaction mixture [14]. The protein concentration was measured with Bradford Reagent (Sigma-Aldrich, St. Louis, MO, USA) [15]. Three independent experiments were performed. Comparisons between control and post-treatment measurements were performed using an unpaired Student’s t-test. Probability values of p \u0026lt; 0.05 were considered statistically significant. 2.5. “Common Deletion” (CD) PCR Phenol-chloroform extraction of total DNA and PCR (Fermentas, Lithuania, Vilnius) were performed according to standard protocols. PCR reaction mixture, for both primer pairs, contained: F primer 2 μM; R primer 2 μM; dNTP 20 mM; Taq Buffer with (NH4)2SO4 and 20 mM MgCl2 1×; Taq polymerase 1 U; DNA 100 ng. All reactions were performed in 25 µL volume in the following conditions: the denaturation step was carried out at 94 C for 3 min, 35 cycles of 94 C for 30 s, 58 C for 30 s, 72 C for 1 min, and a final extension of 72 C for 7 min. See Table 1 for primers used. Table 1. PCR primers for detection of the “common deletion” in mtDNA. PCR primer Orientation Position MT1A F 8224-8247 MT1C F 13176-13198MT2 R 13501-13477PCR reaction with primers MT1A–MT2 was carried out, amplifying a fragment 300 bp in length when the “common deletion” was present. In order to ensure that the absence of CD PCR product is caused by the absence of CD and not by an incorrect PCR reaction, PCR with primers MT1A–MT2 was performed. A corresponding product 325 bp in length is obtained when the mitochondrial genome without the deletion is present and thus serves as a control for the PCR reaction. As a positive control of the PCR reaction, DNA isolated from a patient with a previously confirmed common deletion in mtDNA was used. PCR products were detected by electrophoresis on a 1.5% agarose gel with ethidium bromide against a DNA molecular-weight marker. The gel was photographed under UV transillumination. Three independent experiments were performed. 3. Results and Discussion 3.1. L-Ergothioneine Increases the Reduced Glutathione (GSH) Level The tripeptide glutathione (GSH) is the most abundant intracellular non-protein thiol. It is present predominantly in a reduced form (GSH), which is the biologically active form. Over the years, a great deal of information has been gathered on the role of GSH in maintaining the intracellular reduction–oxidation (redox) environment including antioxidant defense via direct interaction with reactive oxygen\/nitrogen species (ROS\/RNS) or via activities of detoxification enzymes like GSH peroxidases and GSH-S-transferases [16]. In our study we tested the effect of L-ergothioneine on the reduced glutathione (GSH) level in the KB cell line using the GSH\/GSSG-412 colorimetric assay. Our studies showed that L-ergothioneine at the 20 µM concentration (chosen according to our previous studies [17]) increased the reduced glutathione (GSH) level both in control and UVB irradiated Cosmetics 2014, 1 55 KB cells (Table 2). Changes between GSH level in control compared with GSH level after treatment with L-ergothioneine, both in cells exposed and unexposed to UVB, were statistically significant. The UVB light was chosen for the irradiation of KB cells since it is the light of the UVB spectrum that is for the most part absorbed by the epidermis in vivo [18]. UVB may also damage epidermal cells both directly and indirectly by inducing the formation of reactive oxygen species, i.e., the superoxide anion [19]. Thus, it was deemed necessary to study the antioxidative effect of EGT on UVB irradiated epidermis. Table 2. Quantitative determination of glutathione (GSH) level in KB cells. KB cells µmol GSH\/µg protein −UVB +UVB (300 J\/m2) control 6.07 ± 0.15 3.03 ± 0.02 20 µM L-ergothioneine 15.37 ± 0.13 4.65 ± 0.06 Our results are in line with numerous studies demonstrating that L-ergothioneine is an integral component of the cellular antioxidant defense system. It scavenges hydroxyl and peroxynitrite radicals as well as the superoxide anion radical and singlet oxygen. In vitro tests have also demonstrated that EGT also has strong copper chelating ability—it potentially inhibits tyrosinase activity [20–22]. Moreover, in vitro tests have demonstrated that in cultured fibroblasts EGT suppressed the tumor necrosis factor α (TNF α) up-regulation induced by UVB irradiation. In addition in fibroblasts exposed to UVA, EGT suppressed the expression of matrix metalloproteinase 1 (MMP 1) protein [23]. EGT also inhibited nuclear factor kβ (NF kβ) activation and limited the transcriptional activation of the gene for interleukin 8 (IL-8)—a chemotaxin which might account for neutrophil recruitment [24]. It has been demonstrated that EGT is a more powerful antioxidant than either coenzyme Q(10) or idebenone due to its relatively greater efficiency in directly scavenging free radicals and in protecting cells from UV-induced ROS [25]. Recently, a high specific transporter for EGT (ETT) was identified in mammalian tissues, which explains the high tissue levels of EGT and implies a physiological role. Depletion of ETT leads to augmented oxidative stress and cell death. ETT is highly concentrated in the plasma membrane and mitochondria [11]. 3.2. L-Rrgothioneine Shows Protective Properties against the Induction of a Photoaging-Associated mtDNA “Common Deletion” One of the best described mt deletions, the 4977 bp “common deletion”, is known to be involved in photoaging of the skin. Intraindividual comparison studies have revealed that the “common deletion” is increased up to 10-fold in photoaged skin, as compared with sun-protected skin of the same individuals [7]. The objective of our study was to evaluate the effect of L-ergothioneine on the occurrence of mtDNA “common deletion” in UV-irradiated human primary fibroblasts obtained from various donors. For the experiments on dermal cells only UVA irradiation was performed, since the great majority of UVB rays is absorbed by the epidermis and hence never reaches the dermal level [18]. UVA is known to cause mainly indirect damage to cellular structures and nucleic acids by inducing the formation of radical oxygen and nitrogen species but may also be responsible for single- and double-strands breaks in DNA [19]. Thus, exposure to UVA may be one of the main causes Cosmetics 2014, 1 56 of mtDNA mutations including mtDNA deletions [26]. In our experiments, in fibroblasts which were not exposed to UVA we did not observe the “common deletion” after DNA isolation nor during 3 weeks of culture (Figure 2, lanes 9, 11 and 13). When we incubated fibroblasts with L-ergothioneine we also observed no “common deletion” PCR product (Figure 3, lanes 9, 11 and 13). To summarize this part of our study: first of all, cultured fibroblasts isolated from various donors did not initially show the “common deletion”. Secondly, L-ergothioneine, itself, had no influence on the presence of the “common deletion”. Figure 2. Representative PCR analysis of the presence of the “common deletion” in a culture of human fibroblasts incubated with and without UVA exposure, without the presence of L-ergothioneine. M, molecular weight marker; C, control PCR reaction, confirming the presence of mtDNA; 1, fibroblasts after 1 week with UVA exposure; 3, fibroblasts after 2 weeks with UVA exposure; 5, fibroblasts after 3 weeks with UVA exposure; 7, positive control—DNA from a patient with a previously confirmed presence of “common deletion”; 9, fibroblasts after 1 week without UVA exposure; 11, fibroblasts after 2 weeks without UVA exposure; 13 fibroblasts after 3 weeks without UVA exposure. We were able to induce the “common deletion” using repetitive UVA irradiation in cultured human fibroblasts derived from two donors (Figure 2, lanes 1, 3 and 5) suggesting that there is an individual susceptibility to the induction of CD, at least in our in vitro model. Due to the fact that our “common deletion” analysis was performed on fibroblasts isolated from four donors, this requires further studies. When fibroblasts were irradiated and co-incubated with 20 µM L-ergothioneine we did not observe the “common deletion” even after 3 weeks with UVA exposure, suggesting that L-ergothioneine may prevent the formation of this particular damage in mtDNA (Figure 3, lanes 1, 3 and 5). Our results are in accordance with the previous studies where repetitive exposure of keratinocytes, fibroblasts or Cosmetics 2014, 1 57 human skin to UVA at physiological doses was found to induce mutations of mtDNA [7,27–29]. Interestingly, it has been shown that in fibroblasts the level of CD is decreasing with prolonged culture, which can be counteracted with uridine supplementation of culture media [6,7,30]. For this reason, uridine supplementation was employed during all CD analyses in this study. Figure 3. Representative PCR analysis of the presence of the “common deletion” in a culture of human fibroblasts incubated with and without UVA exposure, in the presence of 20 µM L-ergothioneine. M, molecular weight marker; C, control PCR reaction, confirming the presence of mtDNA; 1, fibroblasts after 1 week with UVA exposure; 3, fibroblasts after 2 weeks with UVA exposure; 5, fibroblasts after 3 weeks with UVA exposure; 7, positive control—DNA from a patient with a previously confirmed presence of “common deletion”; 9, fibroblasts after 1 week without UVA exposure; 11, fibroblasts after 2 weeks without UVA exposure; 13, fibroblasts after 3 weeks without UVA exposure. Protection against the induction of a photoaging-associated mtDNA mutation has been also previously shown for two other widely applied cosmetic actives—β-carotene and genistein [31,32]. Our results demonstrated that L-ergothioneine may protect skin cells against some UV-induced damage; in particular against the occurrence of mitDNA “common deletion”. Further studies are required to assess the full-spectrum of L-ergothioneine’s protective activity. We conclude that L-ergothioneine, as an active compound of cosmetic products, shows considerable promise as an effective agent against the aging process. On the other hand, we have shown that in cosmetology, the detection of mtDNA deletions could be a useful tool to assess the effect of active ingredients on UV-irradiated human skin cells. Cosmetics 2014, 1 58 4. Conclusions Aging of human skin has been the subject of a profound interest for cosmetic industry which attempts to counteract this process. In our study we tested L-ergothioneine, one of the antioxidants used in cosmetology, and we found that L-ergothioneine enhanced the level of reduced glutathione and protected against the induction of a photoaging-associated mtDNA “common deletion”. L-Ergothioneine might be involved in the protection of mtDNA from ROS generated in the course of electron transport. In view of these results L-ergothioneine could act as an effective skin care and anti-photo-aging ingredient. On the other hand, we have shown that in cosmetology, the detection of mtDNA deletions could be a useful tool to assess the effect of active ingredients on UV-irradiated human skin cells. Acknowledgments Aleksandra Solyga-Zurek was supported by Ministry of Science and Higher Education project grant ref N N302 119735. Author Contributions Study conception and design: Karolina Bazela, Aleksandra Solyga-Zurek, Renata Debowska, Katarzyna Rogiewicz, Irena Eris; Acquisition of data: Karolina Bazela, Aleksandra Solyga-Zurek; Analysis and interpretation of data: Karolina Bazela, Aleksandra Solyga-Zurek, Renata Debowska; Drafting of manuscript: Karolina Bazela, Aleksandra Solyga-Zurek; Critical revision: Ewa Bartnik. Conflicts of Interest The authors declare no conflict of interest. References 1. Glichrest, B.A. Photoaging. J. Invest. Dermatol. 2013, 133, E2–E6. 2. Bickers, D.R.; Athar, M. Oxidative stress in the pathogenesis of skin disease. J. Invest. Dermatol. 2006, 126, 2565–2575. 3. 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Berneburg, M.; Gattermann, N.; Stege, H.; Grewe, M.; Vogelsang, K.; Ruzicka, T.; Krutmann, J. Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system. Photochem. Photobiol. 1997, 66, 271–275 29. Koch H.; Wittern, K.P.; Bergemann, J. In human keratinocytes the common deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A radiation. J. Invest. Dermatol. 2001, 117, 892–897. 30. Bourgeron, T.; Chretien, D.; Rötig, A.; Munnich, A.; Rustin, P. Fate and expression of the deleted mitochondrial DNA differ between human heteroplasmic skin fibroblast and Epstein-Barr virus-transformed lymphocyte cultures. J. Biol. Chem. 1993, 26, 19369–19376. 31. Wang, Y.N.; Wu, W.; Chen, H.C.; Fang, H. Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation. J. Dermatol. Sci. 2010, 58, 19–27. 32. Eicker, J.; Kürten, V.; Wild, S.; Riss, G.; Goralczyk, R.; Krutmann, J.; Berneburg, M. Betacarotene supplementation protects from photoaging-associated mitochondrial DNA mutation. Photochem. Photobiol. Sci. 2003, 2, 655–659. © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http:\/\/creativecommons.org\/licenses\/by\/3.0\/). Citations (6) References (31) ... l-ergothioneine is a powerful anti-oxidant is extracted at high concentrations from mushrooms such as Portabellas and Criminis species [81]. Owing to the excellent antioxidant properties ergothioneine guards the skin from oxidative and DNA damage and hence it is used in anti-aging creams and lotions [82]. Similarly, Gallic acid is a potentially known to have anti-bacterial and free radical scavenging activities. ... Eminence of Microbial Products in Cosmetic Industry Article Full-text available Jun 2019 Prabuddha Gupta Rajput Mahendrapal Singh Tejas Oza Gaurav Sanghvi View Show abstract Evaluation of the Antioxidant Capacity and Protective Effects of a Comprehensive Topical Antioxidant Containing Water-soluble, Enzymatic, and Lipid-soluble Antioxidants Article Full-text available Apr 2019 David H McDanielJacob M Waugh Lily JiangDiane B Nelson View Show abstract L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms Chapter May 2019 Saraswathy NachimuthuRuckmani Kandasamy Ramalingam PonnusamySivasudha Thilagar View Show abstract Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review Article Full-text available Nov 2016IND CROP PROD Oludemi Taofiq Ana M. Gonzalez-paramas Anabela RL MartinsIsabel C.F.R. Ferreira View Show abstract Production of ergothioneine by Methylobacterium species Article Full-text available Oct 2015 Kabir Md AlamgirSachiko Masuda Yoshiko Fujitani Akio Tani View Show abstract Designing of Biodegradable and Biocompatible Release and Delivery Systems of Selected Antioxidants Used in Cosmetology Article Full-text available Oct 2015Biomacromolecules Magdalena Maksymiak Renata Monika Debowska Karolina Bazela Grazyna Adamus View Show abstract Show more\" rel=\"noopener noreferrer\"\u003e [4\u003c\/a\u003e, \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\") L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e5\u003c\/a\u003e]. In addition to this, the mushroom is a rich source for vitamin D \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24494050\" target=\"_blank\" title=\"Photobiology of vitamin D in mushrooms and its bioavailability in humans\" rel=\"noopener noreferrer\"\u003e[6]\u003c\/a\u003e and also has many polysaccharides and triterpenes that serve as antioxidants and anti-irritants, which stimulate the natural renewal process of the skin. 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This Shiitake liquid extract makes the bioactive compounds within the mushroom readily available to you, to make you feel beautiful!\u003cbr\u003e \u003cbr\u003eTo delve deeper into the world of fungi and to learn more about Shiitake mushrooms and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003elink\u003c\/a\u003e to read our latest blogs . . .\u003cbr\u003e\u003cbr\u003e\n\u003ch3\u003eYour Shiitake Liquid Extract\u003c\/h3\u003e\nDo you want to access the bountiful benefits that the Shiitake mushroom can offer you? Then look no further, Life Cykel’s Australian sourced Shiitake liquid extract will easily supply you with all the mushroom goodness you require! \u003cbr\u003e \n\u003cp\u003e\u003cstrong\u003eCustomer Feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e“I couldn’t believe the strength of my nails and the thickness of my hair after using Shiitake for three weeks. Also, my skin feels smoother and my confidence is up. Thanks to holy Shiitake and the Life Cykel crew!”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Malia, New York\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAdd Shiitake liquid double extract directly to your coffee, smoothie, tea, soup broth or water in the evening for best results.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml\u003c\/p\u003e\n\u003cp\u003eLife Cykel's Shiitake mushrooms and liquid extracts are grown and engineered in the Northern Rivers, NSW.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle \u003cspan\u003e(60 day supply\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Australian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e \u003cspan\u003eDistilled Water, Organic Alcohol,\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eLentinula Edodes.\u003c\/em\u003e\u003c\/span\u003e\u003cspan\u003e (\u003c\/span\u003e\u003cspan\u003e\u003cem\u003eLentinula Edodes\u003c\/em\u003e.\u003c\/span\u003e\u003cspan\u003e Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eLentinula Edodes\u003c\/em\u003e.\u003c\/span\u003e\u003cspan\u003e Fruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage: \u003c\/strong\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMushroom Research:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eMushroom Research:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [2] Yamaguchi, Y., Miyahara, E. and Hihara, J. (2011). Efficacy and Safety of Orally Administered Lentinula edodes Mycelia Extract for Patients Undergoing Cancer Chemotherapy: A Pilot Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe American Journal of Chinese Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 39(03), pp.451–459.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Choi, J., Paik, D.-J., Kwon, D.Y. and Park, Y. (2014). Dietary supplementation with rice bran fermented with Lentinus edodes increases interferon-γ activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eNutrition Journal\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, [online] 13(1).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Nachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Keegan, R.-J. H., Lu, Z., Bogusz, J. M., Williams, J. E., \u0026amp; Holick, M. F. (2013). Photobiology of vitamin D in mushrooms and its bioavailability in humans. Dermato-Endocrinology, 5(1), 165–176. doi:10.4161\/derm.23321\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Cosmetic Benefits of Natural Ingredients: Mushrooms, Feverfew, Tea, and Wheat Complex. Whitney P. Bowe MD. Journal Of Drugs in Dermatology 2013. SUNY Downstate College of Medicine, Brooklyn, NY.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003e\u003cspan\u003e * This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T21:55:43+11:00","created_at":"2018-10-03T20:44:35+10:00","vendor":"Life Cykel","type":"","tags":[],"price":3495,"price_min":3495,"price_max":5295,"available":true,"price_varies":true,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":31070775771196,"title":"120ml","option1":"120ml","option2":null,"option3":null,"sku":"SDE120ml-1","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Shiitake Mushroom Liquid Extract - 120ml","public_title":"120ml","options":["120ml"],"price":5295,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"705632689189"},{"id":31070779670588,"title":"60ml","option1":"60ml","option2":null,"option3":null,"sku":"SDE60ml","requires_shipping":true,"taxable":true,"featured_image":{"id":13341076881468,"product_id":1662038736965,"position":2,"created_at":"2019-10-31T15:13:10+11:00","updated_at":"2019-10-31T15:13:10+11:00","alt":null,"width":970,"height":2000,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.shiitake.60ml.png?v=1572495190","variant_ids":[31070779670588]},"available":false,"name":"Shiitake Mushroom Liquid Extract - 60ml","public_title":"60ml","options":["60ml"],"price":3495,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"0793591581811"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Shiitake_Extract_d56ac7e7-6e3c-4977-ae47-bd096eafaae9.jpg?v=1564227735","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.shiitake.60ml.png?v=1572495190"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Shiitake_Extract_d56ac7e7-6e3c-4977-ae47-bd096eafaae9.jpg?v=1564227735","options":["Size"],"content":"\u003ch2\u003e\u003cstrong\u003eHOLY SHIITAKE\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eConnect to your inner radiance with Life Cykel’s Shiitake Mushroom Extract.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Shiitake mushroom is ranked number 2 in the global mushroom market, for its delicious taste as well as its array of health and beauty benefits \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"entinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e. This mushroom has been utilised as an edible and medicinal mushroom in Asia for many years thanks to its immune regulating and anti-ageing actions \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21598414\" target=\"_blank\" title=\"Efficacy and safety of orally administered Lentinula edodes mycelia extract for patients undergoing cancer chemotherapy: a pilot study.\" rel=\"noopener noreferrer\"\u003e[2].\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eThe Benefits of Shiitake Mushroom\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eThere are many bioactive compounds within the Shiitake mushroom, including the polysaccharide, lentinan, which is shown to increase the activity of the immune system \u003ca href=\"https:\/\/nutritionj.biomedcentral.com\/articles\/10.1186\/1475-2891-13-35\" target=\"_blank\" title=\"Dietary supplementation with rice bran fermented with Lentinus edodesincreases interferon-γ activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study\" rel=\"noopener noreferrer\"\u003e[3].\u003c\/a\u003e Further, beta-gluans and ergosterols found within the mushroom have also been seen to prevent sclerosis (the hardening of arteries), which in turn may support a healthy cardiovascular system \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"entinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e The Shiitake mushroom also works wonders for our skin and hair. The mushroom contains large quantities of the amino acid l-Ergothioneine, which helps to reduce damage from UV light\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\" Article (PDF Available) · March 2014 with 142 Reads DOI: 10.3390\/cosmetics1010051 Cite this publication Karolina Bazela 24.13Dr. Irena Eris Aleksandra Solyga-Zurek + 2 Renata Monika Debowska 23.08Independent Researcher Katarzyna Rogiewicz Show more authors Abstract Many changes related to aging at the cellular level may be due to the physiological condition of mitochondria. One of the most common types of damage of mtDNA is the so-called “common deletion” referring to a deletion of 4977 base pairs. In the skin cells this phenomenon probably is caused by oxidative damage of mtDNA induced by UV. The present study was aimed at evaluating the effect of the antioxidant l-ergothioneine on UV-induced damage in skin cells. The effect of l-ergothioneine on the reduced glutathione level was studied. The presence of the “common deletion” in human fibroblasts irradiated with UVA and treated with l-ergothioneine was evaluated by a polymerase chain reaction. We have demonstrated that l-ergothioneine enhanced the level of reduced glutathione and protected cells from the induction of a photoaging-associated mtDNA “common deletion”. In view of our results, l-ergothioneine could be an effective skin care and anti-photoaging ingredient. Discover the world's research 15+ million members 118+ million publications 700k+ research projects Join for free Figures - available via license: CC BY 4.0 Content may be subject to copyright. Chemical structure of L-ergothioneine. Chemical structure of L-ergothioneine. … . PCR primers for detection of the \u0026quot;common deletion\u0026quot; in mtDNA. . PCR primers for detection of the \u0026quot;common deletion\u0026quot; in mtDNA. … . . … +1 No caption available … Available via license: CC BY 4.0 Content may be subject to copyright. Download full-text PDF Cosmetics 2014, 1, 51-60; doi:10.3390\/cosmetics1010051 cosmetics ISSN 2079-9284 www.mdpi.com\/journal\/cosmetics Communication L-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study Karolina Bazela 1,†,*, Aleksandra Solyga-Zurek 2,†, Renata Debowska 1, Katarzyna Rogiewicz 1, Ewa Bartnik 2 and Irena Eris 1 1 Dr. Irena Eris Cosmetic Laboratories, Centre for Science and Research, Pulawska 107a, Warsaw 02-595, Poland; E-Mails: renata.debowska@eris.pl (R.D.); katarzyna.rogiewicz@eris.pl (K.R.); irena.eris@eris.pl (I.E.) 2 Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, Warsaw 02-106, Poland; E-Mails: asolyga@biol.uw.edu.pl (A.S.-Z.); ebartnik@igib.uw.edu.pl (E.B.) † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: karolina.bazela@eris.pl; Tel.: +48-22-717-1248; Fax: +48-22-757-0612. Received: 31 December 2013; in revised form: 10 March 2014 \/ Accepted: 11 March 2014 \/ Published: 20 March 2014 Abstract: Many changes related to aging at the cellular level may be due to the physiological condition of mitochondria. One of the most common types of damage of mtDNA is the so-called “common deletion” referring to a deletion of 4977 base pairs. In the skin cells this phenomenon probably is caused by oxidative damage of mtDNA induced by UV. The present study was aimed at evaluating the effect of the antioxidant L-ergothioneine on UV-induced damage in skin cells. The effect of L-ergothioneine on the reduced glutathione level was studied. The presence of the “common deletion” in human fibroblasts irradiated with UVA and treated with L-ergothioneine was evaluated by a polymerase chain reaction. We have demonstrated that L-ergothioneine enhanced the level of reduced glutathione and protected cells from the induction of a photoaging-associated mtDNA “common deletion”. In view of our results, L-ergothioneine could be an effective skin care and anti-photoaging ingredient. Keywords: L-ergothioneine; common deletion; mitochondria; photoaging OPEN ACCESS Cosmetics 2014, 1 52 1. Introduction Ultraviolet irradiation is one of the most important environmental factors in the development of a number of skin conditions, ranging from photoaging to cancer. UVA\/B rays penetrate into the skin, reach cells and are absorbed by proteins, lipids, and nuclear and mitochondrial DNA, causing a cascade of oxidative events that can result in progressive deterioration of cellular structure and function [1–3]. There are many theories of aging and a number of them encompass the role of mitochondria in this process. Mitochondria are responsible for producing approximately 90% of the cellular energy in the process of oxidative phosphorylation where electrons from NADH and FADH2 are transferred to oxygen. This generates a significant amount of reactive oxygen species (ROS). Mitochondria are able to counteract the production of ROS with antioxidant defense systems which can detoxify the amount of ROS produced, however, some ROS do evade these processes and are able to damage mitochondrial DNA (mtDNA) as well as proteins and lipids. Mitochondria contain their own DNA (mtDNA), which is distinct from nuclear DNA and more susceptible to damage. Mitochondrial DNA mutations and deletions have been shown to accumulate in many tissues in mammals during aging. mtDNA mutations are thought to arise due to the close proximity to the inner membrane where reactive oxygen species are continually produced in the electron transport chain. This, along with the absence of protective histones and impaired DNA photoproduct repair makes mtDNA a sensitive marker of UV-induced DNA damage [4,5]. It has been shown that photoaged skin is characterized by increased mutations in the mitochondrial (mt) genome [6]. The most frequently reported deletion is a large-scale (4977 bp) deletion also called the “common deletion” (CD). In human skin CD has been shown to occur more frequently with increasing sun exposure and thus appears to be a useful marker rather for UVA induced alterations than for chronological aging [7–10]. The use of antioxidants is an effective approach to prevent symptoms related to photo-induced aging of the skin. Many antioxidants have long been used in cosmetology. L-Ergothioneine (EGT) is an unusual sulphur-containing derivative of an amino acid, histidine, which is acquired by mammals exclusively in their diet. L-Ergothioneine has two functional groups: L-thiol (SH) group and quaternary ammonium group N–(CH3)3 (Figure 1). EGT’s thiol group implies an antioxidant role. The quaternary group EGT resembles carnitine and transfers fatty acids into the mitochondria, therefore increasing the ATP level in cells. EGT is concentrated in cells and tissues frequently exposed to oxidative stress. Numerous in vitro assays have demonstrated the antioxidant and cytoprotective capabilities of EGT against a wide range of cellular stressors [11–13]. Figure 1. Chemical structure of L-ergothioneine. Cosmetics 2014, 1 53 On the basis of these data on the antioxidant activity of L-ergothioneine we found it interesting to study the effect of this substance on UV-induced alterations in skin cell cultures, particularly on mtDNA damage. 2. Experimental Section 2.1. Cell Cultures KB cells (epidermoid carcinoma cell line KB, American Type Culture Collection (ATCC), Manassas, VA, USA) were grown in standard RPMI medium (Invitrogen, Carlsbad, CA, USA), supplemented with 10% fetal calf serum, 2 mM L-glutamine and antibiotics (100 U\/mL penicillin, 0.25 µg\/mL streptomycin sulfate) at 37 °C in 5% CO2. The KB cell line was used as a model representing human keratinocytes. Skin samples, obtained from donors undergoing cosmetic surgery, were treated with dispase II solution (5 mg\/mL, Sigma-Aldrich, St. Louis, MO, USA) at 4 °C for 16 h, followed by separation of dermal and epidermal layers with tweezers. Next, the dermis was cut into ~1 mm2 fragments and treated with 2 mg\/mL collagenase and 0.1 mg\/mL DNase (Sigma-Aldrich, St. Louis, MO, USA) overnight. Liberated cells were seeded into cell culture flasks for culture. Primary human fibroblasts were grown in standard DMEM medium (Invitrogen, Carlsbad, CA, USA), supplemented with 10% fetal calf serum (Invitrogen, Carlsbad, CA, USA), 10 mM HEPES, 2 mM L-glutamine and antibiotics (100 U\/mL penicillin, 0.25 µg\/mL streptomycin sulfate) and 50 µg\/mL uridine, with or without 20 µM L-ergothioneine (Barnet Products Corp.,Englewood Cliffs, NJ, USA), at 37 °C in 5% CO2. Confluent passages between 2 and 8 were used. 2.2. UVB Irradiation Confluent KB cells (control and treated with 20 µM L-ergothioneine (Barnet Products Corp., Englewood Cliffs, NJ, USA)) were exposed to UVB (300 J\/m2, fluorescent bulb TL12 Philips, emission peak at 313 nm) through phosphate buffered saline. 2.3. UVA Irradiation The presence of the “common deletion” was evaluated in fibroblasts derived from 2 female donors aged 38 and 45 and from 2 male donors aged 30 and 42. Cells were grown in the presence of 50 µg\/mL uridine (Sigma-Aldrich, St. Louis, MO, USA), with or without 20 µM L-ergothioneine and irradiated with 3 doses (8 J\/cm2, fluorescent bulb GE F4T5\/BLB, emission peak at 368 nm) of UVA per day, through phosphate buffered saline. This procedure was repeated for 4 consecutive days during 3 weeks. 2.4. Colorimetric Determination of Reduced Glutathione (GSH) GSH level was measured using the GSH\/GSSG-412 assay (OxisResearchTM, Portland, OR, USA)—colorimetric determination of reduced and oxidized glutathione. The method employs Ellmanʼs reagent (5,5'-dithiobis-2-nitrobenzoic acid—DTNB), which reacts with GSH to form a product which is spectrophotometrically detectable at 412 nm. The change in absorbance at 412 nm is Cosmetics 2014, 1 54 a linear function of the GSH concentration in the reaction mixture [14]. The protein concentration was measured with Bradford Reagent (Sigma-Aldrich, St. Louis, MO, USA) [15]. Three independent experiments were performed. Comparisons between control and post-treatment measurements were performed using an unpaired Student’s t-test. Probability values of p \u0026lt; 0.05 were considered statistically significant. 2.5. “Common Deletion” (CD) PCR Phenol-chloroform extraction of total DNA and PCR (Fermentas, Lithuania, Vilnius) were performed according to standard protocols. PCR reaction mixture, for both primer pairs, contained: F primer 2 μM; R primer 2 μM; dNTP 20 mM; Taq Buffer with (NH4)2SO4 and 20 mM MgCl2 1×; Taq polymerase 1 U; DNA 100 ng. All reactions were performed in 25 µL volume in the following conditions: the denaturation step was carried out at 94 C for 3 min, 35 cycles of 94 C for 30 s, 58 C for 30 s, 72 C for 1 min, and a final extension of 72 C for 7 min. See Table 1 for primers used. Table 1. PCR primers for detection of the “common deletion” in mtDNA. PCR primer Orientation Position MT1A F 8224-8247 MT1C F 13176-13198MT2 R 13501-13477PCR reaction with primers MT1A–MT2 was carried out, amplifying a fragment 300 bp in length when the “common deletion” was present. In order to ensure that the absence of CD PCR product is caused by the absence of CD and not by an incorrect PCR reaction, PCR with primers MT1A–MT2 was performed. A corresponding product 325 bp in length is obtained when the mitochondrial genome without the deletion is present and thus serves as a control for the PCR reaction. As a positive control of the PCR reaction, DNA isolated from a patient with a previously confirmed common deletion in mtDNA was used. PCR products were detected by electrophoresis on a 1.5% agarose gel with ethidium bromide against a DNA molecular-weight marker. The gel was photographed under UV transillumination. Three independent experiments were performed. 3. Results and Discussion 3.1. L-Ergothioneine Increases the Reduced Glutathione (GSH) Level The tripeptide glutathione (GSH) is the most abundant intracellular non-protein thiol. It is present predominantly in a reduced form (GSH), which is the biologically active form. Over the years, a great deal of information has been gathered on the role of GSH in maintaining the intracellular reduction–oxidation (redox) environment including antioxidant defense via direct interaction with reactive oxygen\/nitrogen species (ROS\/RNS) or via activities of detoxification enzymes like GSH peroxidases and GSH-S-transferases [16]. In our study we tested the effect of L-ergothioneine on the reduced glutathione (GSH) level in the KB cell line using the GSH\/GSSG-412 colorimetric assay. Our studies showed that L-ergothioneine at the 20 µM concentration (chosen according to our previous studies [17]) increased the reduced glutathione (GSH) level both in control and UVB irradiated Cosmetics 2014, 1 55 KB cells (Table 2). Changes between GSH level in control compared with GSH level after treatment with L-ergothioneine, both in cells exposed and unexposed to UVB, were statistically significant. The UVB light was chosen for the irradiation of KB cells since it is the light of the UVB spectrum that is for the most part absorbed by the epidermis in vivo [18]. UVB may also damage epidermal cells both directly and indirectly by inducing the formation of reactive oxygen species, i.e., the superoxide anion [19]. Thus, it was deemed necessary to study the antioxidative effect of EGT on UVB irradiated epidermis. Table 2. Quantitative determination of glutathione (GSH) level in KB cells. KB cells µmol GSH\/µg protein −UVB +UVB (300 J\/m2) control 6.07 ± 0.15 3.03 ± 0.02 20 µM L-ergothioneine 15.37 ± 0.13 4.65 ± 0.06 Our results are in line with numerous studies demonstrating that L-ergothioneine is an integral component of the cellular antioxidant defense system. It scavenges hydroxyl and peroxynitrite radicals as well as the superoxide anion radical and singlet oxygen. In vitro tests have also demonstrated that EGT also has strong copper chelating ability—it potentially inhibits tyrosinase activity [20–22]. Moreover, in vitro tests have demonstrated that in cultured fibroblasts EGT suppressed the tumor necrosis factor α (TNF α) up-regulation induced by UVB irradiation. In addition in fibroblasts exposed to UVA, EGT suppressed the expression of matrix metalloproteinase 1 (MMP 1) protein [23]. EGT also inhibited nuclear factor kβ (NF kβ) activation and limited the transcriptional activation of the gene for interleukin 8 (IL-8)—a chemotaxin which might account for neutrophil recruitment [24]. It has been demonstrated that EGT is a more powerful antioxidant than either coenzyme Q(10) or idebenone due to its relatively greater efficiency in directly scavenging free radicals and in protecting cells from UV-induced ROS [25]. Recently, a high specific transporter for EGT (ETT) was identified in mammalian tissues, which explains the high tissue levels of EGT and implies a physiological role. Depletion of ETT leads to augmented oxidative stress and cell death. ETT is highly concentrated in the plasma membrane and mitochondria [11]. 3.2. L-Rrgothioneine Shows Protective Properties against the Induction of a Photoaging-Associated mtDNA “Common Deletion” One of the best described mt deletions, the 4977 bp “common deletion”, is known to be involved in photoaging of the skin. Intraindividual comparison studies have revealed that the “common deletion” is increased up to 10-fold in photoaged skin, as compared with sun-protected skin of the same individuals [7]. The objective of our study was to evaluate the effect of L-ergothioneine on the occurrence of mtDNA “common deletion” in UV-irradiated human primary fibroblasts obtained from various donors. For the experiments on dermal cells only UVA irradiation was performed, since the great majority of UVB rays is absorbed by the epidermis and hence never reaches the dermal level [18]. UVA is known to cause mainly indirect damage to cellular structures and nucleic acids by inducing the formation of radical oxygen and nitrogen species but may also be responsible for single- and double-strands breaks in DNA [19]. Thus, exposure to UVA may be one of the main causes Cosmetics 2014, 1 56 of mtDNA mutations including mtDNA deletions [26]. In our experiments, in fibroblasts which were not exposed to UVA we did not observe the “common deletion” after DNA isolation nor during 3 weeks of culture (Figure 2, lanes 9, 11 and 13). When we incubated fibroblasts with L-ergothioneine we also observed no “common deletion” PCR product (Figure 3, lanes 9, 11 and 13). To summarize this part of our study: first of all, cultured fibroblasts isolated from various donors did not initially show the “common deletion”. Secondly, L-ergothioneine, itself, had no influence on the presence of the “common deletion”. Figure 2. Representative PCR analysis of the presence of the “common deletion” in a culture of human fibroblasts incubated with and without UVA exposure, without the presence of L-ergothioneine. M, molecular weight marker; C, control PCR reaction, confirming the presence of mtDNA; 1, fibroblasts after 1 week with UVA exposure; 3, fibroblasts after 2 weeks with UVA exposure; 5, fibroblasts after 3 weeks with UVA exposure; 7, positive control—DNA from a patient with a previously confirmed presence of “common deletion”; 9, fibroblasts after 1 week without UVA exposure; 11, fibroblasts after 2 weeks without UVA exposure; 13 fibroblasts after 3 weeks without UVA exposure. We were able to induce the “common deletion” using repetitive UVA irradiation in cultured human fibroblasts derived from two donors (Figure 2, lanes 1, 3 and 5) suggesting that there is an individual susceptibility to the induction of CD, at least in our in vitro model. Due to the fact that our “common deletion” analysis was performed on fibroblasts isolated from four donors, this requires further studies. When fibroblasts were irradiated and co-incubated with 20 µM L-ergothioneine we did not observe the “common deletion” even after 3 weeks with UVA exposure, suggesting that L-ergothioneine may prevent the formation of this particular damage in mtDNA (Figure 3, lanes 1, 3 and 5). Our results are in accordance with the previous studies where repetitive exposure of keratinocytes, fibroblasts or Cosmetics 2014, 1 57 human skin to UVA at physiological doses was found to induce mutations of mtDNA [7,27–29]. Interestingly, it has been shown that in fibroblasts the level of CD is decreasing with prolonged culture, which can be counteracted with uridine supplementation of culture media [6,7,30]. For this reason, uridine supplementation was employed during all CD analyses in this study. Figure 3. Representative PCR analysis of the presence of the “common deletion” in a culture of human fibroblasts incubated with and without UVA exposure, in the presence of 20 µM L-ergothioneine. M, molecular weight marker; C, control PCR reaction, confirming the presence of mtDNA; 1, fibroblasts after 1 week with UVA exposure; 3, fibroblasts after 2 weeks with UVA exposure; 5, fibroblasts after 3 weeks with UVA exposure; 7, positive control—DNA from a patient with a previously confirmed presence of “common deletion”; 9, fibroblasts after 1 week without UVA exposure; 11, fibroblasts after 2 weeks without UVA exposure; 13, fibroblasts after 3 weeks without UVA exposure. Protection against the induction of a photoaging-associated mtDNA mutation has been also previously shown for two other widely applied cosmetic actives—β-carotene and genistein [31,32]. Our results demonstrated that L-ergothioneine may protect skin cells against some UV-induced damage; in particular against the occurrence of mitDNA “common deletion”. Further studies are required to assess the full-spectrum of L-ergothioneine’s protective activity. We conclude that L-ergothioneine, as an active compound of cosmetic products, shows considerable promise as an effective agent against the aging process. On the other hand, we have shown that in cosmetology, the detection of mtDNA deletions could be a useful tool to assess the effect of active ingredients on UV-irradiated human skin cells. Cosmetics 2014, 1 58 4. Conclusions Aging of human skin has been the subject of a profound interest for cosmetic industry which attempts to counteract this process. In our study we tested L-ergothioneine, one of the antioxidants used in cosmetology, and we found that L-ergothioneine enhanced the level of reduced glutathione and protected against the induction of a photoaging-associated mtDNA “common deletion”. L-Ergothioneine might be involved in the protection of mtDNA from ROS generated in the course of electron transport. In view of these results L-ergothioneine could act as an effective skin care and anti-photo-aging ingredient. On the other hand, we have shown that in cosmetology, the detection of mtDNA deletions could be a useful tool to assess the effect of active ingredients on UV-irradiated human skin cells. Acknowledgments Aleksandra Solyga-Zurek was supported by Ministry of Science and Higher Education project grant ref N N302 119735. Author Contributions Study conception and design: Karolina Bazela, Aleksandra Solyga-Zurek, Renata Debowska, Katarzyna Rogiewicz, Irena Eris; Acquisition of data: Karolina Bazela, Aleksandra Solyga-Zurek; Analysis and interpretation of data: Karolina Bazela, Aleksandra Solyga-Zurek, Renata Debowska; Drafting of manuscript: Karolina Bazela, Aleksandra Solyga-Zurek; Critical revision: Ewa Bartnik. Conflicts of Interest The authors declare no conflict of interest. References 1. Glichrest, B.A. Photoaging. J. Invest. Dermatol. 2013, 133, E2–E6. 2. Bickers, D.R.; Athar, M. Oxidative stress in the pathogenesis of skin disease. J. Invest. Dermatol. 2006, 126, 2565–2575. 3. Puizina-Ivic, N. Skin aging. Acta Derm. 2008, 17, 47–54. 4. Tońska, K.; Sołyga, A.; Bartnik, E. Mitochondria and aging: Innocent bystanders or guilty parties? J. Appl. Genet. 2009, 50, 55–62. 5. Alexeyev, M.F.; LeDoux, S.P.; Wilson, G.L. Mitochondrial DNA and aging. Clin. Sci. 2004, 107, 355–364. 6. Krishnan, K.J.; Greaves, L.C.; Reeve, A.K.; Turnbull, D. The ageing mitochondrial genome. Nucleic Acids Res. 2007, 35, 7399–7405. 7. Birch-Machin, M.A.; Tindall, M.; Turner, R.; Haldane, F.; Rees, J.L. Mitochondrial DNA deletions in human skin reflect photo rather than chronologic aging. J. Invest. Dermatol. 1998, 110, 149–152. 8. Yang, J.H.; Lee, H.C.; Lin, K.J.; Wei, Y.H. A specific 4977-bp deletion of mitochondrial DNA in human ageing skin. Arch. Dermatol. Res. 1994, 286, 386–390. Cosmetics 2014, 1 59 9. Yang, J.H.; Lee, H.C.; Wei, Y.H. Photoageing-associated mitochondrial DNA length mutations in human skin. Arch. Dermatol. Res. 1995, 287, 641–648. 10. Ray, A.J.; Turner, R.; Nikaido, O.; Rees, J.L.; Birch-Machin, M.A. The spectrum of mitochondrial DNA deletions is a ubiquitous marker of ultraviolet radiation exposure in human skin. J. Invest. Dermatol. 2000, 115, 674–679. 11. Paul, B.D.; Snyder, S.H. The unusual amino acid L-ergothioneine is a physiologic cytoprotectant. Cell Death Differ. 2010, 17, 1134–1140. 12. Cheah, I.K.; Halliwell, B. Ergothioneine; antioxidant potential, physiological function and role in disease. Biochim. Biophys. Acta 2012, 1822, 784–793. 13. Markova, N.G.; Karaman-Jurukovska, N.; Dong, K.K.; Damaghi, N.; Smiles, K.A.; Yarosh, D.B. Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system. Free Radic. Biol. Med. 2009, 46, 1168–1176. 14. Tietze, F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal. Biochem. 1969, 27, 502–522. 15. Bradford, M.M. Rapid and sensitive method for quantitation of microgram quantities of protein utilising principle of protein dye binding. Anal. Biochem. 1976, 72, 248–254. 16. Dickinson, D.A.; Forman, H.J. Cellular glutathione and thiols metabolism. Biochem. Pharmacol. 2002, 64, 1019–1026. 17. Bazela, K.; Debowska, R.; Zielinska, A.; Jastrzebska-Brucka, E.; Kawczuga, D.; Eris, I. Protective role of Antioxidant Complex (AC) on human skin cells. In Proceedings of the 3rd International Conference on Oxidative Stress in Skin Medicine and Biology, Andros, Greece, 21–24 September 2006. 18. Kligman, L.H. Photoaging. Manifestations, prevention, and treatment. Dermatol. Clin. 1986, 4, 517–528. 19. Ichihashi, M.; Ueda, M.; Budiyanto, A.; Bito, T.; Oka, M.; Fukunaga, M.; Tsuru, K.; Horikawa, T. UV-induced skin damage. Toxicology 2003, 189, 21–39. 20. Aruoma, O.I.; Spencer, J.P.; Mahmood, N. Protection against oxidative damage and cell death by the natural antioxidant ergothioneine. Food Chem. Toxicol. 1999, 37, 1043–1053. 21. Laurenza, I.; Colognato, R.; Migliore, L.; Del Prato, S.; Benzi, L. Modulation of palmitic acid-induced cell death by ergothioneine: Evidence of an anti-inflammatory action. Biofactors 2008, 33, 237–247. 22. Franzoni, F.; Colognato, R.; Galetta, F.; Laurenza, I.; Barsotti, M.; Di Stefano, R.; Bocchetti, R.; Regoli, F.; Carpi, A.; Balbarini, A.; et al. An in vitro study on the free radical scavenging capacity of ergothioneine: Comparison with reduced glutathione, uric acid and trolox. Biomed. Pharmacother. 2006, 60, 453–457. 23. Obayashi, K.; Kurihara, K.; Okano, Y.; Masaki, H.; Yarosh, D.B. L-Ergothioneine scavenges superoxide and singlet oxygen and suppresses TNF-α and MMP-1 expression in UV-irradiated human dermal fibroblasts. J. Cosmet. Sci. 2005, 56, 17–27. 24. Rahman, I.; Gilmour, P.S.; Jimenez, L.A.; Biswas, S.K.; Antonicelli, F.; Aruoma, O.I. Ergothioneine inhibits oxidative stress- and TNF-α-induced NF-κB activation and interleukin-8 release in alveolar epithelial cells. Biochem. Biophys. Res. Commun. 2003, 302, 860–864. Cosmetics 2014, 1 60 25. Dong, K.K.; Damaghi, N.; Kibitel, J.; Canning, M.T.; Smiles, K.A.; Yarosh, D.B. A comparison of the relative antioxidant potency of L-ergothioneine and idebenone. J. Cosmet. Dermatol. 2007, 6, 183–188. 26. Krishnan, K.J.; Reeve, A.K.; Samuels, D.C.; Chinnery, P.F.; Blackwood, J.K.; Taylor, R.W.; Wanrooij, S.; Spelbrink, J.N.; Lightowlers, R.N.; Turnbull, D.M. What causes mitochondrial DNA deletions in human cells? Nat. Genet. 2008, 40, 275–279. 27. Berneburg, M.; Plettenberg, H.; Medve-König, K.; Pfahlberg, A.; Gers-Barlag, H.; Gefeller, O.; Krutmann, J. Induction of the photoaging-associated mitochondrial common deletion in vivo in normal human skin. J. Invest. Dermatol. 2004, 122, 1277–1283. 28. Berneburg, M.; Gattermann, N.; Stege, H.; Grewe, M.; Vogelsang, K.; Ruzicka, T.; Krutmann, J. Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system. Photochem. Photobiol. 1997, 66, 271–275 29. Koch H.; Wittern, K.P.; Bergemann, J. In human keratinocytes the common deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A radiation. J. Invest. Dermatol. 2001, 117, 892–897. 30. Bourgeron, T.; Chretien, D.; Rötig, A.; Munnich, A.; Rustin, P. Fate and expression of the deleted mitochondrial DNA differ between human heteroplasmic skin fibroblast and Epstein-Barr virus-transformed lymphocyte cultures. J. Biol. Chem. 1993, 26, 19369–19376. 31. Wang, Y.N.; Wu, W.; Chen, H.C.; Fang, H. Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation. J. Dermatol. Sci. 2010, 58, 19–27. 32. Eicker, J.; Kürten, V.; Wild, S.; Riss, G.; Goralczyk, R.; Krutmann, J.; Berneburg, M. Betacarotene supplementation protects from photoaging-associated mitochondrial DNA mutation. Photochem. Photobiol. Sci. 2003, 2, 655–659. © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http:\/\/creativecommons.org\/licenses\/by\/3.0\/). Citations (6) References (31) ... l-ergothioneine is a powerful anti-oxidant is extracted at high concentrations from mushrooms such as Portabellas and Criminis species [81]. Owing to the excellent antioxidant properties ergothioneine guards the skin from oxidative and DNA damage and hence it is used in anti-aging creams and lotions [82]. Similarly, Gallic acid is a potentially known to have anti-bacterial and free radical scavenging activities. ... Eminence of Microbial Products in Cosmetic Industry Article Full-text available Jun 2019 Prabuddha Gupta Rajput Mahendrapal Singh Tejas Oza Gaurav Sanghvi View Show abstract Evaluation of the Antioxidant Capacity and Protective Effects of a Comprehensive Topical Antioxidant Containing Water-soluble, Enzymatic, and Lipid-soluble Antioxidants Article Full-text available Apr 2019 David H McDanielJacob M Waugh Lily JiangDiane B Nelson View Show abstract L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms Chapter May 2019 Saraswathy NachimuthuRuckmani Kandasamy Ramalingam PonnusamySivasudha Thilagar View Show abstract Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review Article Full-text available Nov 2016IND CROP PROD Oludemi Taofiq Ana M. Gonzalez-paramas Anabela RL MartinsIsabel C.F.R. Ferreira View Show abstract Production of ergothioneine by Methylobacterium species Article Full-text available Oct 2015 Kabir Md AlamgirSachiko Masuda Yoshiko Fujitani Akio Tani View Show abstract Designing of Biodegradable and Biocompatible Release and Delivery Systems of Selected Antioxidants Used in Cosmetology Article Full-text available Oct 2015Biomacromolecules Magdalena Maksymiak Renata Monika Debowska Karolina Bazela Grazyna Adamus View Show abstract Show more\" rel=\"noopener noreferrer\"\u003e [4\u003c\/a\u003e, \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\") L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e5\u003c\/a\u003e]. In addition to this, the mushroom is a rich source for vitamin D \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24494050\" target=\"_blank\" title=\"Photobiology of vitamin D in mushrooms and its bioavailability in humans\" rel=\"noopener noreferrer\"\u003e[6]\u003c\/a\u003e and also has many polysaccharides and triterpenes that serve as antioxidants and anti-irritants, which stimulate the natural renewal process of the skin. Therefore this mushroom can be particularly effective in skin care applications that protect against photoageing and improving skin elasticity \u003ca href=\"https:\/\/jddonline.com\/articles\/dermatology\/S1545961613S0133X\/\" target=\"_blank\" title=\"Cosmetic Benefits of Natural Ingredients: Mushrooms, Feverfew, Tea, and Wheat Complex\" rel=\"noopener noreferrer\"\u003e[7]\u003c\/a\u003e.\u003cbr\u003e\u003cbr\u003e\n\u003ch3\u003e\u003cstrong\u003eThe Use of Shiitake Liquid Extract\u003c\/strong\u003e\u003c\/h3\u003e\nThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today. As is the effortless way of incorporating these mushroom extracts into your day to day life. This Shiitake liquid extract makes the bioactive compounds within the mushroom readily available to you, to make you feel beautiful!\u003cbr\u003e \u003cbr\u003eTo delve deeper into the world of fungi and to learn more about Shiitake mushrooms and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003elink\u003c\/a\u003e to read our latest blogs . . .\u003cbr\u003e\u003cbr\u003e\n\u003ch3\u003eYour Shiitake Liquid Extract\u003c\/h3\u003e\nDo you want to access the bountiful benefits that the Shiitake mushroom can offer you? Then look no further, Life Cykel’s Australian sourced Shiitake liquid extract will easily supply you with all the mushroom goodness you require! \u003cbr\u003e \n\u003cp\u003e\u003cstrong\u003eCustomer Feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e“I couldn’t believe the strength of my nails and the thickness of my hair after using Shiitake for three weeks. Also, my skin feels smoother and my confidence is up. Thanks to holy Shiitake and the Life Cykel crew!”\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Malia, New York\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAdd Shiitake liquid double extract directly to your coffee, smoothie, tea, soup broth or water in the evening for best results.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml\u003c\/p\u003e\n\u003cp\u003eLife Cykel's Shiitake mushrooms and liquid extracts are grown and engineered in the Northern Rivers, NSW.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle \u003cspan\u003e(60 day supply\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003e- 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Australian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e \u003cspan\u003eDistilled Water, Organic Alcohol,\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eLentinula Edodes.\u003c\/em\u003e\u003c\/span\u003e\u003cspan\u003e (\u003c\/span\u003e\u003cspan\u003e\u003cem\u003eLentinula Edodes\u003c\/em\u003e.\u003c\/span\u003e\u003cspan\u003e Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e\u003c\/span\u003e\u003cspan\u003e \u003cem\u003eLentinula Edodes\u003c\/em\u003e.\u003c\/span\u003e\u003cspan\u003e Fruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage: \u003c\/strong\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMushroom Research:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding.\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eMushroom Research:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [2] Yamaguchi, Y., Miyahara, E. and Hihara, J. (2011). Efficacy and Safety of Orally Administered Lentinula edodes Mycelia Extract for Patients Undergoing Cancer Chemotherapy: A Pilot Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe American Journal of Chinese Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 39(03), pp.451–459.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Choi, J., Paik, D.-J., Kwon, D.Y. and Park, Y. (2014). Dietary supplementation with rice bran fermented with Lentinus edodes increases interferon-γ activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eNutrition Journal\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, [online] 13(1).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Nachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Keegan, R.-J. H., Lu, Z., Bogusz, J. M., Williams, J. E., \u0026amp; Holick, M. F. (2013). Photobiology of vitamin D in mushrooms and its bioavailability in humans. Dermato-Endocrinology, 5(1), 165–176. doi:10.4161\/derm.23321\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Cosmetic Benefits of Natural Ingredients: Mushrooms, Feverfew, Tea, and Wheat Complex. Whitney P. Bowe MD. Journal Of Drugs in Dermatology 2013. SUNY Downstate College of Medicine, Brooklyn, NY.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003e\u003cspan\u003e * This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/details\u003e"} [{"id":92048490565,"handle":"all","title":"All","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2019-02-18T10:20:43+11:00","sort_order":"best-selling","template_suffix":"","disjunctive":false,"rules":[{"column":"variant_price","relation":"greater_than","condition":"0"},{"column":"variant_inventory","relation":"greater_than","condition":"0"},{"column":"type","relation":"not_equals","condition":"Insurance"}],"published_scope":"web"},{"id":80859955269,"handle":"liquid-extracts","title":"Liquid Mushroom Extract - The Elixir of Life","updated_at":"2019-11-12T12:30:03+11:00","body_html":"\u003cp\u003eGive your body and mind proper support on your journey to vitality and longevity. Find the best organic liquid Mushroom extracts at Life Cykel today!\u003c\/p\u003e\n\u003cp\u003eFor thousands of years, traditional medicine has used mushroom tinctures as a primary means of treatment, due to the vast array of health benefits they provide. The positive outcomes and the strong faith in the power of the mushroom liquid extract, has gained them the title ”\u003cstrong\u003e\u003cem\u003eelixirs of life\u003c\/em\u003e\u003c\/strong\u003e”. These beneficial mushrooms have mainly been used in Asia \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e, but are now spreading to all corners of the world, and are being named \u003cstrong\u003e\u003cem\u003efunctional mushrooms.\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdetails\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eFunctional mushrooms are considered a superfood and are now commonly used as dietary supplements \u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09168451.2018.1431519?journalCode=tbbb20\" target=\"_blank\" title=\"Biologically functional molecules from mushroom-forming fungi. \" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003eToday, we are discovering more and more about the benefits of using these mushrooms and extensive research is being undertaken to understand the bioactive compounds within the mushrooms that provide them with such power.\u003c\/p\u003e\n\u003cp\u003e By using Life Cykel’s mushroom liquid extract, as a supplement in your everyday diet, you can effortlessly give your body and mind the proper support it requires on your mission of health and wellness.\u003c\/p\u003e\n\u003cp\u003e Life Cykel's liquid \u003cstrong\u003e\u003cem\u003edouble\u003c\/em\u003e\u003c\/strong\u003e extracts have been carefully created to be some of the most potent mushroom extracts in the world. Our extract range includes Reishi, Cordyceps, Shiitake, Lion's Mane and Turkey Tail mushrooms.\u003c\/p\u003e\n\u003cp\u003eNot only do we provide you with the best mushroom liquid extract, when producing our extracts we aim to integrate Circular Economy principles wherever possible and where available we're using Australian native mushroom strains that have been meticulously infused with Australian native, wild harvested Kakadu Plum.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/lions-mane-mushroom-liquid-extract\" title=\"Buy Lion's Mane Liquid Extract\"\u003eLion’s Mane Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eLion's Mane Mushroom is known for its positive effects on cognitive health \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24266378\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" rel=\"noopener noreferrer\"\u003e[3]\u003c\/a\u003e. This mushroom is rich in bioactive components \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26244378\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" rel=\"noopener noreferrer\"\u003e[5]\u003c\/a\u003e, which could be responsible for some important physiological activities, this includes antioxidant and anti- inflammatory activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26559695\" title=\"The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\"\u003e [6\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906890\/\" target=\"_blank\" title=\"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities\" rel=\"noopener noreferrer\"\u003e7]\u003c\/a\u003e and neural growth \u003ca href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jnatprod.6b00371?src=recsys\" target=\"_blank\" title=\"Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e, improving memory and focus as well as enhancing your dreams and mood \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31118969\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?\" rel=\"noopener noreferrer\"\u003e[8]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/cordyceps-mushroom-liquid-extract\" title=\"Buy Cordyceps Liquid Extract\"\u003eCordyceps Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eCordyceps mushroom is an extraordinary mushroom. The bioactive compounds within the mushroom, show to promote anti-inflammatory, anti-microbial and anti-oxidative activities (anti-ageing) [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=86265\" target=\"_blank\" title=\"The Effect of the Hot Water Extracts of the Paecilomyces hepiali and Cordyceps militaris Mycelia on the Growth of Gastrointestinal Bacteria\" rel=\"noopener noreferrer\"\u003e10]\u003c\/a\u003e, as well as having beneficial effects on lipid metabolism [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24231073\" target=\"_blank\" title=\"Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice.\" rel=\"noopener noreferrer\"\u003e11]\u003c\/a\u003e and may improve your endurance to prolonged and high intensity exercise \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e[9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5236007\/\" target=\"_blank\" title=\"Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation\" rel=\"noopener noreferrer\"\u003e12\u003c\/a\u003e,\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28094746\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming.\" rel=\"noopener noreferrer\"\u003e13\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/reishi-mushroom-liquid-extract\" title=\"Buy Reishi Liquid Extract\"\u003eReishi Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eFor many millennia the Reishi mushroom has been used to treat a variety of diseases, including cardiovascular diseases and insomnia \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e[14]\u003c\/a\u003e. The constituents within the mushroom may help to enhance anti-microbial, anti-oxidant and immunomodulating activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e [14\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ingentaconnect.com\/contentone\/ben\/cpb\/2016\/00000017\/00000003\/art00010\" target=\"_blank\" title=\"Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents\" rel=\"noopener noreferrer\"\u003e15\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24386913\" target=\"_blank\" title=\"Concentration variation and molecular characteristics of soluble (1,3;1,6)-β-D-glucans in submerged cultivation products of Ganoderma lucidum mycelium\" rel=\"noopener noreferrer\"\u003e16\u003c\/a\u003e]. The mushroom is also well known for its beneficial effects on sleep and relaxation [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e17\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Extract+of+Ganoderma+lucidum+prolongs+sleep+time+in+rats\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats\" rel=\"noopener noreferrer\"\u003e18\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/turkey-tail-mushroom-liquid-extract\" title=\"Buy Turkey Tail Liquid Extract\"\u003eTurkey Tail Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eThe Turkey Tail mushroom is mainly consumed to regulate the immune system. However, more recent research is also showing evidence that the mushroom may have the ability of modulating the composition of the human microbiome [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25006989\" target=\"_blank\" title=\"Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial\" rel=\"noopener noreferrer\"\u003e19\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23435630\" target=\"_blank\" title=\"Trametes versicolor extract modifies human fecal microbiota composition in vitro.\" rel=\"noopener noreferrer\"\u003e20]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/shiitake-mushroom-liquid-extract\" title=\"Buy Shiitake Liquid Extract\"\u003eShiitake mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eShiitake mushrooms have been utilised for their anti-sclerotic (reduce hardening of arteries) activities as well as helping to reduce damage from UV light and helping to increase the renewal process of the skin, therefore this mushroom could be considered as an effective anti-photoaging and skin care ingredient \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\"L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e[21,\u003c\/a\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\"l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study\" rel=\"noopener noreferrer\"\u003e 22,\u003c\/a\u003e \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e23]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eLearn more about our mushrooms by browsing our range of liquid mushroom extracts below or click \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003ehere\u003c\/u\u003e\u003c\/a\u003e to read our latest blogs on these fantastic fungi!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2] Choi, J.-H. (2018). Biologically functional molecules from mushroom-forming fungi. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eBioscience, Biotechnology, and Biochemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 82(3), pp.372–382.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [8] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eExperimental and Therapeutic Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 12(1), pp.513–517.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[9] Das, S.K., Masuda, M., Sakurai, A. and Sakakibara, M. (2010). Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eFitoterapia\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 81(8), pp.961–968.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[10] Ko and Leung. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[11] Gamage, S., Nakayama, J., Fuyuno, Y. and Ohga, S. (2018). The Effect of the Hot Water Extracts of the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePaecilomyces hepiali \u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003eand \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCordyceps militaris\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e Mycelia on the Growth of Gastrointestinal Bacteria. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdvances in Microbiology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 08(07), pp.490–505.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[12] Kim, S.B., Ahn, B., Kim, M., Ji, H.-J., Shin, S.-K., Hong, I.P., Kim, C.Y., Hwang, B.Y. and Lee, M.K. (2014). Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 151(1), pp.478–484.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [13] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[14] Cilerdzic, J., Stajic, M. and Vukojevic, J. (2016). Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCurrent Pharmaceutical Biotechnology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(3), pp.275–282.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[15] Wang, C.-H., Hsieh, S.-C., Wang, H.-J., Chen, M.-L., Lin, B.-F., Chiang, B.-H. and Lu, T.-J. (2014). Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 62(3), pp.634–641.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[16] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[17] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[18] Pallav, K., Dowd, S.E., Villafuerte, J., Yang, X., Kabbani, T., Hansen, J., Dennis, M., Leffler, D.A., Newburg, D.S. and Kelly, C.P. (2014). Effects of polysaccharopeptide fromTrametes Versicolorand amoxicillin on the gut microbiome of healthy volunteers. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eGut Microbes\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 5(4), pp.458–467.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[19] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePlant Foods for Human Nutrition\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 68(2), pp.107–112\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[20] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eNachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[21] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[22] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T22:45:41+11:00","sort_order":"best-selling","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-03T21:01:43+10:00","alt":"","width":2657,"height":2657,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/Reishi_Liquid_Extract.jpg?v=1561725306"}},{"id":81919148101,"handle":"our-most-popular-products","title":"Our most popular products","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2018-10-09T20:31:53+11:00","sort_order":"manual","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-09T21:38:37+11:00","alt":"","width":1000,"height":1061,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/mushroom-box-grown_9f7cd2ae-9917-4975-be1f-7e05481b2d9d.jpg?v=1539081517"}}]$34.95 AUD
Cordyceps Mushroom Liquid Extract
{"id":1662060363845,"title":"Cordyceps Mushroom Liquid Extract","handle":"cordyceps-mushroom-liquid-extract","description":"\u003ch1\u003eThe Mighty Cordyceps Mushroom\u003c\/h1\u003e\n\u003cp\u003eThe Cordyceps mushroom is an extraordinary fungi to say the least, it is commonly known to enhance your energy levels\u003cspan style=\"color: #00aaff;\"\u003e \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e[1,\u003c\/span\u003e\u003c\/a\u003e \u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/19390211.2016.1203386?journalCode=ijds20\" target=\"_blank\" title=\"Cordyceps militarisImproves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation\" style=\"color: #00aaff; text-decoration: underline;\" rel=\"noopener noreferrer\"\u003e6\u003c\/a\u003e\u003c\/span\u003e, \u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,57162b26264a3b98,4ad6a16757705f93.html\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming\" style=\"color: #00aaff; text-decoration: underline;\" rel=\"noopener noreferrer\"\u003e7]\u003c\/a\u003e.\u003c\/span\u003e\u003c\/span\u003e This mushroom has been extensively used in traditional Chinese medicine for centuries, due to its abundant source of health benefits when consumed \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: #00aaff; text-decoration: underline;\"\u003e[1\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0367326X10001863\" target=\"_blank\" title=\"Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: #00aaff; text-decoration: underline;\"\u003e2]\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eThis mushroom is traditionally used to treat fatigue, low sex drive and kidney disease \u003ca href=\"https:\/\/cmjournal.biomedcentral.com\/articles\/10.1186\/1749-8546-2-3\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: #00aaff; text-decoration: underline;\"\u003e[3]\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e. However, as the Cordyceps mushroom has spread globally, more research is discovering important bioactive compounds within the mushroom, in particular the amino acid cordycepin, as well as many polysaccharides and ergosterols that promote biological activities which are extremely beneficial to our health and wellbeing \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0367326X10001863\" target=\"_blank\" title=\"Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eThe Benefits of Cordyceps Mushroom\u003c\/h2\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eThe extensive research into the Cordyceps mushroom shows that the bioactive compounds found within the mushroom can reduce inflammation, increase libido, prevent oxidative stress (anti-ageing) \u003cspan style=\"color: #00aaff;\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0367326X10001863\" target=\"_blank\" title=\"Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects\" style=\"color: #00aaff; text-decoration: underline;\" rel=\"noopener noreferrer\"\u003e[2\u003c\/a\u003e]\u003c\/span\u003e \u003c\/span\u003eand hold antimicrobial effects \u003ca href=\"https:\/\/www.researchgate.net\/publication\/326626497_The_Effect_of_the_Hot_Water_Extracts_of_the_Paecilomyces_hepiali_and_Cordyceps_militaris_Mycelia_on_the_Growth_of_Gastrointestinal_Bacteria\" target=\"_blank\" title=\"The Effect of the Hot Water Extracts of the Paecilomyces hepiali and Cordyceps militaris Mycelia on the Growth of Gastrointestinal Bacteria\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: #00aaff; text-decoration: underline;\"\u003e[4]\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e, and this is just to name a few of the benefits of this powerful mushroom.\u003c\/p\u003e\n\u003cp\u003eThe Cordyceps mushroom is popularly known for its potential to provide energy, research shows that the mushroom may have beneficial effects on lipid metabolism \u003cspan\u003e[\u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874113007903?via%3Dihub\" target=\"_blank\" title=\"Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice\" rel=\"noopener noreferrer\"\u003e5\u003c\/a\u003e, \u003ca href=\"https:\/\/www.semanticscholar.org\/paper\/Lipid-lowering-effect-of-cordycepin-from-Cordyceps-Gao-Lian\/271445936cac5c2d0c0c01156618feb0ce08c521\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"color: #00aaff;\" title=\". “Lipid-lowering effect of cordycepin (3'-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats.” \"\u003e9\u003c\/a\u003e\u003cspan\u003e]\u003c\/span\u003e, protection of your mitochondria – the power house of the cell [\u003cspan\u003e\u003ca href=\"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X10008494\" target=\"_blank\" title=\"Protective Effects on Mitochondria and Anti-Aging Activity of Polysaccharides from Cultivated Fruiting Bodies of Cordyceps militaris\" rel=\"noopener noreferrer\"\u003e8\u003c\/a\u003e\u003c\/span\u003e\u003cspan\u003e] \u003c\/span\u003eand can improve your endurance to prolonged and high intensity exercise \u003cspan style=\"color: #00aaff;\"\u003e [\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: #00aaff; text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/cmjournal.biomedcentral.com\/articles\/10.1186\/1749-8546-2-3\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs\" rel=\"noopener noreferrer\"\u003e3\u003c\/a\u003e ,\u003c\/span\u003e\u003c\/span\u003e\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/19390211.2016.1203386?journalCode=ijds20\" target=\"_blank\" title=\"Cordyceps militarisImproves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e6\u003c\/a\u003e, \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,57162b26264a3b98,4ad6a16757705f93.html\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e7\u003c\/a\u003e]\u003c\/span\u003e\u003cspan\u003e.\u003c\/span\u003eThis mushroom will really get you going!\u003c\/p\u003e\n\u003ch3\u003eThe Use of Cordyceps Liquid Extract\u003c\/h3\u003e\n\u003cp\u003eThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today. As is the effortless way of incorporating mushroom tinctures into your day to day life. This Cordyceps mushroom liquid extract makes the bioactive compounds readily available to you to kick start your day.\u003c\/p\u003e\n\u003cp\u003eTo delve deeper into the world of fungi and to learn more about Cordyceps mushrooms and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: #00aaff; text-decoration: underline;\"\u003elink\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003cspan color=\"#00aaff\" style=\"color: #00aaff;\"\u003e \u003c\/span\u003eto to read our latest blogs.\u003c\/p\u003e\n\u003ch4\u003eYour Cordyceps Liquid Double Extract\u003c\/h4\u003e\n\u003cp\u003eMany people are now seeking the great benefits from the Cordyceps mushroom and that is why Life Cykel is bringing to you an easy way to access all the mushroom goodness in our mushroom liquid extract.\u003c\/p\u003e\n\u003cp\u003eSo, if you need that little extra boost in your day, then you’re in the right place to buy Cordyceps mushroom liquid extract, one of Australia’s most unique products.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCustomer feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e“I had heard a lot about Cordyceps and was wondering whether it would live up to its reputation but I was surprisingly impressed and found myself back on the rowing machine and lifting weights with all the extra energy I got.\"\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Sam, Brisbane\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eSome of our customers include: athletes, people with active lifestyles, gymnasts, performers, hikers, professional sports players and doers.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add Cordyceps liquid double extract directly to your coffee, smoothie, tea or water in the morning for best results.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e\u003cspan\u003e 2 \u003c\/span\u003eml \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eLife Cykel's Cordyceps mushroom liquid double extracts are engineered in the Northern Rivers, NSW.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle (60 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eOriginally harvested in the USA\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eAustralian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eINGREDIENTS\u003c\/strong\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eDistilled Water, Organic Alcohol, \u003c\/span\u003e\u003ci\u003eCordyceps militaris.\u003c\/i\u003e\u003cspan\u003e (\u003c\/span\u003e\u003ci\u003eCordyceps militaris. \u003c\/i\u003eMycelial biomass and\u003ci\u003e Cordyceps militaris. \u003c\/i\u003e\u003cspan\u003eFruiting Body), Natural Wild Harvested Kakadu Plum\u003ci\u003e.\u003c\/i\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage: \u003c\/strong\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMushroom Research:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e[1] Chang, S.-T. and Wasser, S.P. (2012). The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health. \u003cem\u003eInternational Journal of Medicinal Mushrooms\u003c\/em\u003e, 14(2), pp.95–134.\u003c\/li\u003e\n\u003cli\u003e\n\u003cp style=\"display: inline !important;\"\u003e[2] Das, S.K., Masuda, M., Sakurai, A. and Sakakibara, M. (2010). Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects. \u003cem\u003eFitoterapia\u003c\/em\u003e, 81(8), pp.961–968.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e[3] Ko and Leung. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China\u003c\/li\u003e\n\u003cli\u003e[4] Gamage, S., Nakayama, J., Fuyuno, Y. and Ohga, S. (2018). The Effect of the Hot Water Extracts of the \u003cem\u003ePaecilomyces hepiali \u003c\/em\u003eand \u003cem\u003eCordyceps militaris\u003c\/em\u003e Mycelia on the Growth of Gastrointestinal Bacteria. \u003cem\u003eAdvances in Microbiology\u003c\/em\u003e, 08(07), pp.490–505.\u003c\/li\u003e\n\u003cli\u003e[5] Kim, S.B., Ahn, B., Kim, M., Ji, H.-J., Shin, S.-K., Hong, I.P., Kim, C.Y., Hwang, B.Y. and Lee, M.K. (2014). Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice. \u003cem\u003eJournal of Ethnopharmacology\u003c\/em\u003e, 151(1), pp.478–484.\u003c\/li\u003e\n\u003cli\u003e[6] Hirsch, K.R., Smith-Ryan, A.E., Roelofs, E.J., Trexler, E.T. and Mock, M.G. (2016). Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. \u003cem\u003eJournal of Dietary Supplements\u003c\/em\u003e, 14(1), pp.42–53.\u003c\/li\u003e\n\u003cli\u003e[7] Xu, Y.-F. (2016). Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming. \u003cem\u003eInternational Journal of Medicinal Mushrooms\u003c\/em\u003e, 18(12), pp.1083–1092.\u003c\/li\u003e\n\u003cli\u003e[8] Li, X.-T., Li, H.-C., Li, C.-B., Dou, D.-Q. and Gao, M.-B. (2010). Protective Effects on Mitochondria and Anti-Aging Activity of Polysaccharides from Cultivated Fruiting Bodies of Cordyceps militaris. \u003cem\u003eThe American Journal of Chinese Medicine\u003c\/em\u003e, 38(06), pp.1093–1106.\u003c\/li\u003e\n\u003cli\u003e[9] Gao, Jian et al. “Lipid-lowering effect of cordycepin (3'-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats.” \u003cem\u003eYao xue xue bao = Acta pharmaceutica Sinica\u003c\/em\u003e 46 6 (2011): 669-76 \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e* This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T21:37:01+11:00","created_at":"2018-10-03T20:47:51+10:00","vendor":"Life Cykel","type":"","tags":[],"price":3495,"price_min":3495,"price_max":5295,"available":true,"price_varies":true,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":31069797449788,"title":"120ml","option1":"120ml","option2":null,"option3":null,"sku":"CDE120ml-1","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Cordyceps Mushroom Liquid Extract - 120ml","public_title":"120ml","options":["120ml"],"price":5295,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"705632689172"},{"id":31070714560572,"title":"60ml","option1":"60ml","option2":null,"option3":null,"sku":"CDE60ml","requires_shipping":true,"taxable":true,"featured_image":{"id":13340987588668,"product_id":1662060363845,"position":2,"created_at":"2019-10-31T14:57:49+11:00","updated_at":"2019-10-31T14:57:49+11:00","alt":null,"width":1117,"height":1500,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.cordyceps.60ml.png?v=1572494269","variant_ids":[31070714560572]},"available":false,"name":"Cordyceps Mushroom Liquid Extract - 60ml","public_title":"60ml","options":["60ml"],"price":3495,"weight":500,"compare_at_price":null,"inventory_management":"shopify","barcode":"0793591711218"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Cordyceps_Extract.png?v=1564227601","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.cordyceps.60ml.png?v=1572494269"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Cordyceps_Extract.png?v=1564227601","options":["Size"],"content":"\u003ch1\u003eThe Mighty Cordyceps Mushroom\u003c\/h1\u003e\n\u003cp\u003eThe Cordyceps mushroom is an extraordinary fungi to say the least, it is commonly known to enhance your energy levels\u003cspan style=\"color: #00aaff;\"\u003e \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e[1,\u003c\/span\u003e\u003c\/a\u003e \u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/19390211.2016.1203386?journalCode=ijds20\" target=\"_blank\" title=\"Cordyceps militarisImproves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation\" style=\"color: #00aaff; text-decoration: underline;\" rel=\"noopener noreferrer\"\u003e6\u003c\/a\u003e\u003c\/span\u003e, \u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,57162b26264a3b98,4ad6a16757705f93.html\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming\" style=\"color: #00aaff; text-decoration: underline;\" rel=\"noopener noreferrer\"\u003e7]\u003c\/a\u003e.\u003c\/span\u003e\u003c\/span\u003e This mushroom has been extensively used in traditional Chinese medicine for centuries, due to its abundant source of health benefits when consumed \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: #00aaff; text-decoration: underline;\"\u003e[1\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0367326X10001863\" target=\"_blank\" title=\"Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: #00aaff; text-decoration: underline;\"\u003e2]\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eThis mushroom is traditionally used to treat fatigue, low sex drive and kidney disease \u003ca href=\"https:\/\/cmjournal.biomedcentral.com\/articles\/10.1186\/1749-8546-2-3\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: #00aaff; text-decoration: underline;\"\u003e[3]\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e. However, as the Cordyceps mushroom has spread globally, more research is discovering important bioactive compounds within the mushroom, in particular the amino acid cordycepin, as well as many polysaccharides and ergosterols that promote biological activities which are extremely beneficial to our health and wellbeing \u003cspan style=\"color: #00aaff;\"\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0367326X10001863\" target=\"_blank\" title=\"Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eThe Benefits of Cordyceps Mushroom\u003c\/h2\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eThe extensive research into the Cordyceps mushroom shows that the bioactive compounds found within the mushroom can reduce inflammation, increase libido, prevent oxidative stress (anti-ageing) \u003cspan style=\"color: #00aaff;\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0367326X10001863\" target=\"_blank\" title=\"Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects\" style=\"color: #00aaff; text-decoration: underline;\" rel=\"noopener noreferrer\"\u003e[2\u003c\/a\u003e]\u003c\/span\u003e \u003c\/span\u003eand hold antimicrobial effects \u003ca href=\"https:\/\/www.researchgate.net\/publication\/326626497_The_Effect_of_the_Hot_Water_Extracts_of_the_Paecilomyces_hepiali_and_Cordyceps_militaris_Mycelia_on_the_Growth_of_Gastrointestinal_Bacteria\" target=\"_blank\" title=\"The Effect of the Hot Water Extracts of the Paecilomyces hepiali and Cordyceps militaris Mycelia on the Growth of Gastrointestinal Bacteria\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: #00aaff; text-decoration: underline;\"\u003e[4]\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e, and this is just to name a few of the benefits of this powerful mushroom.\u003c\/p\u003e\n\u003cp\u003eThe Cordyceps mushroom is popularly known for its potential to provide energy, research shows that the mushroom may have beneficial effects on lipid metabolism \u003cspan\u003e[\u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874113007903?via%3Dihub\" target=\"_blank\" title=\"Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice\" rel=\"noopener noreferrer\"\u003e5\u003c\/a\u003e, \u003ca href=\"https:\/\/www.semanticscholar.org\/paper\/Lipid-lowering-effect-of-cordycepin-from-Cordyceps-Gao-Lian\/271445936cac5c2d0c0c01156618feb0ce08c521\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"color: #00aaff;\" title=\". “Lipid-lowering effect of cordycepin (3'-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats.” \"\u003e9\u003c\/a\u003e\u003cspan\u003e]\u003c\/span\u003e, protection of your mitochondria – the power house of the cell [\u003cspan\u003e\u003ca href=\"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X10008494\" target=\"_blank\" title=\"Protective Effects on Mitochondria and Anti-Aging Activity of Polysaccharides from Cultivated Fruiting Bodies of Cordyceps militaris\" rel=\"noopener noreferrer\"\u003e8\u003c\/a\u003e\u003c\/span\u003e\u003cspan\u003e] \u003c\/span\u003eand can improve your endurance to prolonged and high intensity exercise \u003cspan style=\"color: #00aaff;\"\u003e [\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: #00aaff; text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/cmjournal.biomedcentral.com\/articles\/10.1186\/1749-8546-2-3\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs\" rel=\"noopener noreferrer\"\u003e3\u003c\/a\u003e ,\u003c\/span\u003e\u003c\/span\u003e\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/19390211.2016.1203386?journalCode=ijds20\" target=\"_blank\" title=\"Cordyceps militarisImproves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e6\u003c\/a\u003e, \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,57162b26264a3b98,4ad6a16757705f93.html\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming\" style=\"color: #00aaff;\" rel=\"noopener noreferrer\"\u003e7\u003c\/a\u003e]\u003c\/span\u003e\u003cspan\u003e.\u003c\/span\u003eThis mushroom will really get you going!\u003c\/p\u003e\n\u003ch3\u003eThe Use of Cordyceps Liquid Extract\u003c\/h3\u003e\n\u003cp\u003eThe simple and clean method of extracting the beneficial bioactive compounds from mushrooms in alcohol, to create a liquid extract, is still applicable today. As is the effortless way of incorporating mushroom tinctures into your day to day life. This Cordyceps mushroom liquid extract makes the bioactive compounds readily available to you to kick start your day.\u003c\/p\u003e\n\u003cp\u003eTo delve deeper into the world of fungi and to learn more about Cordyceps mushrooms and other functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: #00aaff; text-decoration: underline;\"\u003elink\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003cspan color=\"#00aaff\" style=\"color: #00aaff;\"\u003e \u003c\/span\u003eto to read our latest blogs.\u003c\/p\u003e\n\u003ch4\u003eYour Cordyceps Liquid Double Extract\u003c\/h4\u003e\n\u003cp\u003eMany people are now seeking the great benefits from the Cordyceps mushroom and that is why Life Cykel is bringing to you an easy way to access all the mushroom goodness in our mushroom liquid extract.\u003c\/p\u003e\n\u003cp\u003eSo, if you need that little extra boost in your day, then you’re in the right place to buy Cordyceps mushroom liquid extract, one of Australia’s most unique products.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCustomer feedback:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e“I had heard a lot about Cordyceps and was wondering whether it would live up to its reputation but I was surprisingly impressed and found myself back on the rowing machine and lifting weights with all the extra energy I got.\"\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e- Sam, Brisbane\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eSome of our customers include: athletes, people with active lifestyles, gymnasts, performers, hikers, professional sports players and doers.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add Cordyceps liquid double extract directly to your coffee, smoothie, tea or water in the morning for best results.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e\u003cspan\u003e 2 \u003c\/span\u003eml \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eLife Cykel's Cordyceps mushroom liquid double extracts are engineered in the Northern Rivers, NSW.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e120 ml bottle (60 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e60 ml bottle (30 day supply - 2 ml a day)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Non-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003e Vegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eOriginally harvested in the USA\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eAustralian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan style=\"font-weight: 400;\"\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eINGREDIENTS\u003c\/strong\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cstrong\u003e:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eDistilled Water, Organic Alcohol, \u003c\/span\u003e\u003ci\u003eCordyceps militaris.\u003c\/i\u003e\u003cspan\u003e (\u003c\/span\u003e\u003ci\u003eCordyceps militaris. \u003c\/i\u003eMycelial biomass and\u003ci\u003e Cordyceps militaris. \u003c\/i\u003e\u003cspan\u003eFruiting Body), Natural Wild Harvested Kakadu Plum\u003ci\u003e.\u003c\/i\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage: \u003c\/strong\u003eStore in a cool, dry place\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePlease note - we do not deliver to countries that do not allow alcohol based products in their postal service. In these cases we suggest to order our mushroom powder products instead. Thank you for your understanding\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMushroom Research:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e[1] Chang, S.-T. and Wasser, S.P. (2012). The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health. \u003cem\u003eInternational Journal of Medicinal Mushrooms\u003c\/em\u003e, 14(2), pp.95–134.\u003c\/li\u003e\n\u003cli\u003e\n\u003cp style=\"display: inline !important;\"\u003e[2] Das, S.K., Masuda, M., Sakurai, A. and Sakakibara, M. (2010). Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects. \u003cem\u003eFitoterapia\u003c\/em\u003e, 81(8), pp.961–968.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e[3] Ko and Leung. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China\u003c\/li\u003e\n\u003cli\u003e[4] Gamage, S., Nakayama, J., Fuyuno, Y. and Ohga, S. (2018). The Effect of the Hot Water Extracts of the \u003cem\u003ePaecilomyces hepiali \u003c\/em\u003eand \u003cem\u003eCordyceps militaris\u003c\/em\u003e Mycelia on the Growth of Gastrointestinal Bacteria. \u003cem\u003eAdvances in Microbiology\u003c\/em\u003e, 08(07), pp.490–505.\u003c\/li\u003e\n\u003cli\u003e[5] Kim, S.B., Ahn, B., Kim, M., Ji, H.-J., Shin, S.-K., Hong, I.P., Kim, C.Y., Hwang, B.Y. and Lee, M.K. (2014). Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice. \u003cem\u003eJournal of Ethnopharmacology\u003c\/em\u003e, 151(1), pp.478–484.\u003c\/li\u003e\n\u003cli\u003e[6] Hirsch, K.R., Smith-Ryan, A.E., Roelofs, E.J., Trexler, E.T. and Mock, M.G. (2016). Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. \u003cem\u003eJournal of Dietary Supplements\u003c\/em\u003e, 14(1), pp.42–53.\u003c\/li\u003e\n\u003cli\u003e[7] Xu, Y.-F. (2016). Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming. \u003cem\u003eInternational Journal of Medicinal Mushrooms\u003c\/em\u003e, 18(12), pp.1083–1092.\u003c\/li\u003e\n\u003cli\u003e[8] Li, X.-T., Li, H.-C., Li, C.-B., Dou, D.-Q. and Gao, M.-B. (2010). Protective Effects on Mitochondria and Anti-Aging Activity of Polysaccharides from Cultivated Fruiting Bodies of Cordyceps militaris. \u003cem\u003eThe American Journal of Chinese Medicine\u003c\/em\u003e, 38(06), pp.1093–1106.\u003c\/li\u003e\n\u003cli\u003e[9] Gao, Jian et al. “Lipid-lowering effect of cordycepin (3'-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats.” \u003cem\u003eYao xue xue bao = Acta pharmaceutica Sinica\u003c\/em\u003e 46 6 (2011): 669-76 \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e* This product is not intended to diagnose, treat, cure or prevent any disease\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/details\u003e"} [{"id":92048490565,"handle":"all","title":"All","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2019-02-18T10:20:43+11:00","sort_order":"best-selling","template_suffix":"","disjunctive":false,"rules":[{"column":"variant_price","relation":"greater_than","condition":"0"},{"column":"variant_inventory","relation":"greater_than","condition":"0"},{"column":"type","relation":"not_equals","condition":"Insurance"}],"published_scope":"web"},{"id":80859955269,"handle":"liquid-extracts","title":"Liquid Mushroom Extract - The Elixir of Life","updated_at":"2019-11-12T12:30:03+11:00","body_html":"\u003cp\u003eGive your body and mind proper support on your journey to vitality and longevity. Find the best organic liquid Mushroom extracts at Life Cykel today!\u003c\/p\u003e\n\u003cp\u003eFor thousands of years, traditional medicine has used mushroom tinctures as a primary means of treatment, due to the vast array of health benefits they provide. The positive outcomes and the strong faith in the power of the mushroom liquid extract, has gained them the title ”\u003cstrong\u003e\u003cem\u003eelixirs of life\u003c\/em\u003e\u003c\/strong\u003e”. These beneficial mushrooms have mainly been used in Asia \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e, but are now spreading to all corners of the world, and are being named \u003cstrong\u003e\u003cem\u003efunctional mushrooms.\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdetails\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eFunctional mushrooms are considered a superfood and are now commonly used as dietary supplements \u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09168451.2018.1431519?journalCode=tbbb20\" target=\"_blank\" title=\"Biologically functional molecules from mushroom-forming fungi. \" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003eToday, we are discovering more and more about the benefits of using these mushrooms and extensive research is being undertaken to understand the bioactive compounds within the mushrooms that provide them with such power.\u003c\/p\u003e\n\u003cp\u003e By using Life Cykel’s mushroom liquid extract, as a supplement in your everyday diet, you can effortlessly give your body and mind the proper support it requires on your mission of health and wellness.\u003c\/p\u003e\n\u003cp\u003e Life Cykel's liquid \u003cstrong\u003e\u003cem\u003edouble\u003c\/em\u003e\u003c\/strong\u003e extracts have been carefully created to be some of the most potent mushroom extracts in the world. Our extract range includes Reishi, Cordyceps, Shiitake, Lion's Mane and Turkey Tail mushrooms.\u003c\/p\u003e\n\u003cp\u003eNot only do we provide you with the best mushroom liquid extract, when producing our extracts we aim to integrate Circular Economy principles wherever possible and where available we're using Australian native mushroom strains that have been meticulously infused with Australian native, wild harvested Kakadu Plum.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/lions-mane-mushroom-liquid-extract\" title=\"Buy Lion's Mane Liquid Extract\"\u003eLion’s Mane Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eLion's Mane Mushroom is known for its positive effects on cognitive health \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24266378\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" rel=\"noopener noreferrer\"\u003e[3]\u003c\/a\u003e. This mushroom is rich in bioactive components \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26244378\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" rel=\"noopener noreferrer\"\u003e[5]\u003c\/a\u003e, which could be responsible for some important physiological activities, this includes antioxidant and anti- inflammatory activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26559695\" title=\"The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\"\u003e [6\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906890\/\" target=\"_blank\" title=\"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities\" rel=\"noopener noreferrer\"\u003e7]\u003c\/a\u003e and neural growth \u003ca href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jnatprod.6b00371?src=recsys\" target=\"_blank\" title=\"Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e, improving memory and focus as well as enhancing your dreams and mood \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31118969\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?\" rel=\"noopener noreferrer\"\u003e[8]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/cordyceps-mushroom-liquid-extract\" title=\"Buy Cordyceps Liquid Extract\"\u003eCordyceps Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eCordyceps mushroom is an extraordinary mushroom. The bioactive compounds within the mushroom, show to promote anti-inflammatory, anti-microbial and anti-oxidative activities (anti-ageing) [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=86265\" target=\"_blank\" title=\"The Effect of the Hot Water Extracts of the Paecilomyces hepiali and Cordyceps militaris Mycelia on the Growth of Gastrointestinal Bacteria\" rel=\"noopener noreferrer\"\u003e10]\u003c\/a\u003e, as well as having beneficial effects on lipid metabolism [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24231073\" target=\"_blank\" title=\"Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice.\" rel=\"noopener noreferrer\"\u003e11]\u003c\/a\u003e and may improve your endurance to prolonged and high intensity exercise \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e[9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5236007\/\" target=\"_blank\" title=\"Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation\" rel=\"noopener noreferrer\"\u003e12\u003c\/a\u003e,\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28094746\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming.\" rel=\"noopener noreferrer\"\u003e13\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/reishi-mushroom-liquid-extract\" title=\"Buy Reishi Liquid Extract\"\u003eReishi Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eFor many millennia the Reishi mushroom has been used to treat a variety of diseases, including cardiovascular diseases and insomnia \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e[14]\u003c\/a\u003e. The constituents within the mushroom may help to enhance anti-microbial, anti-oxidant and immunomodulating activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e [14\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ingentaconnect.com\/contentone\/ben\/cpb\/2016\/00000017\/00000003\/art00010\" target=\"_blank\" title=\"Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents\" rel=\"noopener noreferrer\"\u003e15\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24386913\" target=\"_blank\" title=\"Concentration variation and molecular characteristics of soluble (1,3;1,6)-β-D-glucans in submerged cultivation products of Ganoderma lucidum mycelium\" rel=\"noopener noreferrer\"\u003e16\u003c\/a\u003e]. The mushroom is also well known for its beneficial effects on sleep and relaxation [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e17\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Extract+of+Ganoderma+lucidum+prolongs+sleep+time+in+rats\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats\" rel=\"noopener noreferrer\"\u003e18\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/turkey-tail-mushroom-liquid-extract\" title=\"Buy Turkey Tail Liquid Extract\"\u003eTurkey Tail Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eThe Turkey Tail mushroom is mainly consumed to regulate the immune system. However, more recent research is also showing evidence that the mushroom may have the ability of modulating the composition of the human microbiome [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25006989\" target=\"_blank\" title=\"Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial\" rel=\"noopener noreferrer\"\u003e19\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23435630\" target=\"_blank\" title=\"Trametes versicolor extract modifies human fecal microbiota composition in vitro.\" rel=\"noopener noreferrer\"\u003e20]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/shiitake-mushroom-liquid-extract\" title=\"Buy Shiitake Liquid Extract\"\u003eShiitake mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eShiitake mushrooms have been utilised for their anti-sclerotic (reduce hardening of arteries) activities as well as helping to reduce damage from UV light and helping to increase the renewal process of the skin, therefore this mushroom could be considered as an effective anti-photoaging and skin care ingredient \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\"L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e[21,\u003c\/a\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\"l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study\" rel=\"noopener noreferrer\"\u003e 22,\u003c\/a\u003e \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e23]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eLearn more about our mushrooms by browsing our range of liquid mushroom extracts below or click \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003ehere\u003c\/u\u003e\u003c\/a\u003e to read our latest blogs on these fantastic fungi!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2] Choi, J.-H. (2018). Biologically functional molecules from mushroom-forming fungi. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eBioscience, Biotechnology, and Biochemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 82(3), pp.372–382.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [8] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eExperimental and Therapeutic Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 12(1), pp.513–517.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[9] Das, S.K., Masuda, M., Sakurai, A. and Sakakibara, M. (2010). Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eFitoterapia\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 81(8), pp.961–968.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[10] Ko and Leung. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[11] Gamage, S., Nakayama, J., Fuyuno, Y. and Ohga, S. (2018). The Effect of the Hot Water Extracts of the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePaecilomyces hepiali \u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003eand \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCordyceps militaris\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e Mycelia on the Growth of Gastrointestinal Bacteria. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdvances in Microbiology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 08(07), pp.490–505.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[12] Kim, S.B., Ahn, B., Kim, M., Ji, H.-J., Shin, S.-K., Hong, I.P., Kim, C.Y., Hwang, B.Y. and Lee, M.K. (2014). Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 151(1), pp.478–484.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [13] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[14] Cilerdzic, J., Stajic, M. and Vukojevic, J. (2016). Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCurrent Pharmaceutical Biotechnology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(3), pp.275–282.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[15] Wang, C.-H., Hsieh, S.-C., Wang, H.-J., Chen, M.-L., Lin, B.-F., Chiang, B.-H. and Lu, T.-J. (2014). Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 62(3), pp.634–641.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[16] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[17] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[18] Pallav, K., Dowd, S.E., Villafuerte, J., Yang, X., Kabbani, T., Hansen, J., Dennis, M., Leffler, D.A., Newburg, D.S. and Kelly, C.P. (2014). Effects of polysaccharopeptide fromTrametes Versicolorand amoxicillin on the gut microbiome of healthy volunteers. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eGut Microbes\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 5(4), pp.458–467.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[19] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePlant Foods for Human Nutrition\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 68(2), pp.107–112\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[20] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eNachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[21] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[22] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T22:45:41+11:00","sort_order":"best-selling","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-03T21:01:43+10:00","alt":"","width":2657,"height":2657,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/Reishi_Liquid_Extract.jpg?v=1561725306"}},{"id":81919148101,"handle":"our-most-popular-products","title":"Our most popular products","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2018-10-09T20:31:53+11:00","sort_order":"manual","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-09T21:38:37+11:00","alt":"","width":1000,"height":1061,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/mushroom-box-grown_9f7cd2ae-9917-4975-be1f-7e05481b2d9d.jpg?v=1539081517"}}]$34.95 AUD
Biohacker Set - 5 Extracts
{"id":3865110970437,"title":"Biohacker Set - 5 Extracts","handle":"cordyceps-reishi-turkey-tail-shiitake-mushrooms","description":"\u003ch2\u003eBuy 4 Extracts Get 1 Free \u003c\/h2\u003e\n\u003cp\u003eThis is the Ultimate Professional Biohacker Value Pack!\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIncludes the following Double Liquid Extracts (120ml each):\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e- Lion's Mane\u003cbr\u003e- Cordyceps\u003cbr\u003e- Reishi\u003cbr\u003e- Turkey Tail\u003cbr\u003e- Shiitake\u003c\/p\u003e\n\u003cp\u003eTry out our full range of mushroom extracts and have the tools that are needed to bring a smooth flowing day into your life and bring out your best, to benefit yourself and the people around you. \u003cspan\u003eOur double extracts have been carefully created in the Northern Rivers, NSW and make it super easy to add some mushroom goodness to your daily routine. The mushrooms used in our double extracts have been grown locally by integrating Circular Economy principles. Our mushroom strains have been meticulously infused with Australian native, wild harvested Kakadu Plum. We call this our \"perfect fusion\". We hope you feel the mushroom and bush essence of living in harmony.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eLion's Mane\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eSome of our customers include: authors, poets, mathematicians, scientists, brain trauma patients, academics, students, mindful people, biohackers, corporate professionals, information technologists, travellers and dreamers.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e\u003cspan\u003e: Distilled Water, Organic Alcohol, Australian Hericium coralloides (Hericium coralloides Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e Hericium coralloides Fruiting Body), Natural Wild Harvest Kakadu Plum \u003c\/span\u003e \u003c\/p\u003e\n\u003ch3\u003eCordyceps\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eSome of our customers include: athletes, people with active lifestyles, gymnasts, performers, hikers, professional sports players and doers.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eINGREDIENTS\u003c\/strong\u003e\u003cstrong\u003e:\u003c\/strong\u003e Distilled Water, Organic Alcohol, \u003ci\u003eCordyceps militaris\u003c\/i\u003e (\u003ci\u003eCordyceps militaris. \u003c\/i\u003eFruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eReishi\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eSome of our customers include: chillers, relaxers, deep breathers, meditators, yoga and Pilates practitioners, mystics, bohemians, surfers, channelers, people in flow, gardeners, kind people, missionaries and musicians.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e: Distilled Water, Organic Alcohol, Ganoderma lucidium (Ganoderma lucidium Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e Ganoderma lucidium Fruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eTurkey Tail\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eSome of our customers include: airplane travellers, young families, city people, prebiotic enthusiasts, balanced humans, gut focused people, partiers, seekers of immunity, talkers, walkers, workers and contributors.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e Distilled Water, Alcohol, Australian \u003ci\u003eTrametes versicolor \u003c\/i\u003e(\u003ci\u003eTrametes versicolor \u003c\/i\u003eMycelial Biomass, Tra\u003ci\u003emetes versicolor \u003c\/i\u003eFruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eShiitake\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eSome of our customers include: beauticians, dermatologists self lovers, nutritionists, naturopaths, perfectionists, models, actors, radiant people, inner beauty babes, sensual people, gods and goddesses.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e Distilled Water, Organic Alcohol, Lentinula Edodes (Lentinula E. Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e Lentinula E. Fruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add your liquid double extracts directly to your coffee, smoothie, tea or water.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003e120 ml bottles (60 day supply each extract - 2 ml per day)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e60 ml bottles (30 day supply each extract - 2 ml per day)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eNon-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eVegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eAustralian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml \u003c\/p\u003e\n\u003cstrong\u003eStorage: \u003c\/strong\u003eStore in a cool, dry place","published_at":"2019-06-28T14:43:56+10:00","created_at":"2019-06-28T22:25:23+10:00","vendor":"Life Cykel","type":"","tags":["exclude","specials"],"price":13980,"price_min":13980,"price_max":21180,"available":true,"price_varies":true,"compare_at_price":17475,"compare_at_price_min":17475,"compare_at_price_max":26475,"compare_at_price_varies":true,"variants":[{"id":31083076485180,"title":"120ml","option1":"120ml","option2":null,"option3":null,"sku":"LDE5SET120ml","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Biohacker Set - 5 Extracts - 120ml","public_title":"120ml","options":["120ml"],"price":21180,"weight":1560,"compare_at_price":26475,"inventory_management":"shopify","barcode":"793591581781"},{"id":31083353997372,"title":"60ml","option1":"60ml","option2":null,"option3":null,"sku":"LDE5SET60ml","requires_shipping":true,"taxable":true,"featured_image":{"id":13352516812860,"product_id":3865110970437,"position":4,"created_at":"2019-11-01T16:18:02+11:00","updated_at":"2019-11-01T16:18:02+11:00","alt":null,"width":2713,"height":1499,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.set.60ml.png?v=1572585482","variant_ids":[31083353997372]},"available":true,"name":"Biohacker Set - 5 Extracts - 60ml","public_title":"60ml","options":["60ml"],"price":13980,"weight":1040,"compare_at_price":17475,"inventory_management":"shopify","barcode":""}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Reishi_Liquid_Extract_800x_8c3492f1-2e36-4c4a-b6c7-1b564fc62d64.jpg?v=1562024796","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Aus_Extract_Range.JPG?v=1562024797","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/P8100361.jpg?v=1572585482","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/aust.set.60ml.png?v=1572585482"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Reishi_Liquid_Extract_800x_8c3492f1-2e36-4c4a-b6c7-1b564fc62d64.jpg?v=1562024796","options":["Size"],"content":"\u003ch2\u003eBuy 4 Extracts Get 1 Free \u003c\/h2\u003e\n\u003cp\u003eThis is the Ultimate Professional Biohacker Value Pack!\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIncludes the following Double Liquid Extracts (120ml each):\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e- Lion's Mane\u003cbr\u003e- Cordyceps\u003cbr\u003e- Reishi\u003cbr\u003e- Turkey Tail\u003cbr\u003e- Shiitake\u003c\/p\u003e\n\u003cp\u003eTry out our full range of mushroom extracts and have the tools that are needed to bring a smooth flowing day into your life and bring out your best, to benefit yourself and the people around you. \u003cspan\u003eOur double extracts have been carefully created in the Northern Rivers, NSW and make it super easy to add some mushroom goodness to your daily routine. The mushrooms used in our double extracts have been grown locally by integrating Circular Economy principles. Our mushroom strains have been meticulously infused with Australian native, wild harvested Kakadu Plum. We call this our \"perfect fusion\". We hope you feel the mushroom and bush essence of living in harmony.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eLion's Mane\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eSome of our customers include: authors, poets, mathematicians, scientists, brain trauma patients, academics, students, mindful people, biohackers, corporate professionals, information technologists, travellers and dreamers.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e\u003cspan\u003e: Distilled Water, Organic Alcohol, Australian Hericium coralloides (Hericium coralloides Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e Hericium coralloides Fruiting Body), Natural Wild Harvest Kakadu Plum \u003c\/span\u003e \u003c\/p\u003e\n\u003ch3\u003eCordyceps\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eSome of our customers include: athletes, people with active lifestyles, gymnasts, performers, hikers, professional sports players and doers.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eINGREDIENTS\u003c\/strong\u003e\u003cstrong\u003e:\u003c\/strong\u003e Distilled Water, Organic Alcohol, \u003ci\u003eCordyceps militaris\u003c\/i\u003e (\u003ci\u003eCordyceps militaris. \u003c\/i\u003eFruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eReishi\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eSome of our customers include: chillers, relaxers, deep breathers, meditators, yoga and Pilates practitioners, mystics, bohemians, surfers, channelers, people in flow, gardeners, kind people, missionaries and musicians.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cb\u003eINGREDIENTS\u003c\/b\u003e: Distilled Water, Organic Alcohol, Ganoderma lucidium (Ganoderma lucidium Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e Ganoderma lucidium Fruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eTurkey Tail\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eSome of our customers include: airplane travellers, young families, city people, prebiotic enthusiasts, balanced humans, gut focused people, partiers, seekers of immunity, talkers, walkers, workers and contributors.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e Distilled Water, Alcohol, Australian \u003ci\u003eTrametes versicolor \u003c\/i\u003e(\u003ci\u003eTrametes versicolor \u003c\/i\u003eMycelial Biomass, Tra\u003ci\u003emetes versicolor \u003c\/i\u003eFruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eShiitake\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eSome of our customers include: beauticians, dermatologists self lovers, nutritionists, naturopaths, perfectionists, models, actors, radiant people, inner beauty babes, sensual people, gods and goddesses.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e Distilled Water, Organic Alcohol, Lentinula Edodes (Lentinula E. Mycelial Biomass,\u003ci\u003e\u003c\/i\u003e Lentinula E. Fruiting Body), Natural Wild Harvested Kakadu Plum\u003c\/span\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e Add your liquid double extracts directly to your coffee, smoothie, tea or water.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003e120 ml bottles (60 day supply each extract - 2 ml per day)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003e60 ml bottles (30 day supply each extract - 2 ml per day)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eNon-GMO\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eVegan-friendly\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eGluten free\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eAustralian sourced ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 2 ml \u003c\/p\u003e\n\u003cstrong\u003eStorage: \u003c\/strong\u003eStore in a cool, dry place"} [{"id":92048490565,"handle":"all","title":"All","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2019-02-18T10:20:43+11:00","sort_order":"best-selling","template_suffix":"","disjunctive":false,"rules":[{"column":"variant_price","relation":"greater_than","condition":"0"},{"column":"variant_inventory","relation":"greater_than","condition":"0"},{"column":"type","relation":"not_equals","condition":"Insurance"}],"published_scope":"web"},{"id":80859955269,"handle":"liquid-extracts","title":"Liquid Mushroom Extract - The Elixir of Life","updated_at":"2019-11-12T12:30:03+11:00","body_html":"\u003cp\u003eGive your body and mind proper support on your journey to vitality and longevity. Find the best organic liquid Mushroom extracts at Life Cykel today!\u003c\/p\u003e\n\u003cp\u003eFor thousands of years, traditional medicine has used mushroom tinctures as a primary means of treatment, due to the vast array of health benefits they provide. The positive outcomes and the strong faith in the power of the mushroom liquid extract, has gained them the title ”\u003cstrong\u003e\u003cem\u003eelixirs of life\u003c\/em\u003e\u003c\/strong\u003e”. These beneficial mushrooms have mainly been used in Asia \u003ca href=\"http:\/\/www.dl.begellhouse.com\/journals\/708ae68d64b17c52,28491335273756b2,5b2516df6bbf4bbd.html\" target=\"_blank\" title=\"The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e, but are now spreading to all corners of the world, and are being named \u003cstrong\u003e\u003cem\u003efunctional mushrooms.\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdetails\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003eFunctional mushrooms are considered a superfood and are now commonly used as dietary supplements \u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09168451.2018.1431519?journalCode=tbbb20\" target=\"_blank\" title=\"Biologically functional molecules from mushroom-forming fungi. \" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003eToday, we are discovering more and more about the benefits of using these mushrooms and extensive research is being undertaken to understand the bioactive compounds within the mushrooms that provide them with such power.\u003c\/p\u003e\n\u003cp\u003e By using Life Cykel’s mushroom liquid extract, as a supplement in your everyday diet, you can effortlessly give your body and mind the proper support it requires on your mission of health and wellness.\u003c\/p\u003e\n\u003cp\u003e Life Cykel's liquid \u003cstrong\u003e\u003cem\u003edouble\u003c\/em\u003e\u003c\/strong\u003e extracts have been carefully created to be some of the most potent mushroom extracts in the world. Our extract range includes Reishi, Cordyceps, Shiitake, Lion's Mane and Turkey Tail mushrooms.\u003c\/p\u003e\n\u003cp\u003eNot only do we provide you with the best mushroom liquid extract, when producing our extracts we aim to integrate Circular Economy principles wherever possible and where available we're using Australian native mushroom strains that have been meticulously infused with Australian native, wild harvested Kakadu Plum.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/lions-mane-mushroom-liquid-extract\" title=\"Buy Lion's Mane Liquid Extract\"\u003eLion’s Mane Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eLion's Mane Mushroom is known for its positive effects on cognitive health \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24266378\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia.\" rel=\"noopener noreferrer\"\u003e[3]\u003c\/a\u003e. This mushroom is rich in bioactive components \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26244378\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" rel=\"noopener noreferrer\"\u003e[5]\u003c\/a\u003e, which could be responsible for some important physiological activities, this includes antioxidant and anti- inflammatory activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26559695\" title=\"The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\"\u003e [6\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906890\/\" target=\"_blank\" title=\"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities\" rel=\"noopener noreferrer\"\u003e7]\u003c\/a\u003e and neural growth \u003ca href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.jnatprod.6b00371?src=recsys\" target=\"_blank\" title=\"Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e, improving memory and focus as well as enhancing your dreams and mood \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31118969\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?\" rel=\"noopener noreferrer\"\u003e[8]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/cordyceps-mushroom-liquid-extract\" title=\"Buy Cordyceps Liquid Extract\"\u003eCordyceps Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eCordyceps mushroom is an extraordinary mushroom. The bioactive compounds within the mushroom, show to promote anti-inflammatory, anti-microbial and anti-oxidative activities (anti-ageing) [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=86265\" target=\"_blank\" title=\"The Effect of the Hot Water Extracts of the Paecilomyces hepiali and Cordyceps militaris Mycelia on the Growth of Gastrointestinal Bacteria\" rel=\"noopener noreferrer\"\u003e10]\u003c\/a\u003e, as well as having beneficial effects on lipid metabolism [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24231073\" target=\"_blank\" title=\"Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice.\" rel=\"noopener noreferrer\"\u003e11]\u003c\/a\u003e and may improve your endurance to prolonged and high intensity exercise \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.\" rel=\"noopener noreferrer\"\u003e[9\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5236007\/\" target=\"_blank\" title=\"Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation\" rel=\"noopener noreferrer\"\u003e12\u003c\/a\u003e,\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28094746\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming.\" rel=\"noopener noreferrer\"\u003e13\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/reishi-mushroom-liquid-extract\" title=\"Buy Reishi Liquid Extract\"\u003eReishi Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eFor many millennia the Reishi mushroom has been used to treat a variety of diseases, including cardiovascular diseases and insomnia \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e[14]\u003c\/a\u003e. The constituents within the mushroom may help to enhance anti-microbial, anti-oxidant and immunomodulating activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/\" target=\"_blank\" title=\"Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom\" rel=\"noopener noreferrer\"\u003e [14\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ingentaconnect.com\/contentone\/ben\/cpb\/2016\/00000017\/00000003\/art00010\" target=\"_blank\" title=\"Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents\" rel=\"noopener noreferrer\"\u003e15\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24386913\" target=\"_blank\" title=\"Concentration variation and molecular characteristics of soluble (1,3;1,6)-β-D-glucans in submerged cultivation products of Ganoderma lucidum mycelium\" rel=\"noopener noreferrer\"\u003e16\u003c\/a\u003e]. The mushroom is also well known for its beneficial effects on sleep and relaxation [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism.\" rel=\"noopener noreferrer\"\u003e17\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Extract+of+Ganoderma+lucidum+prolongs+sleep+time+in+rats\" target=\"_blank\" title=\"Extract of Ganoderma lucidum prolongs sleep time in rats\" rel=\"noopener noreferrer\"\u003e18\u003c\/a\u003e].\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/turkey-tail-mushroom-liquid-extract\" title=\"Buy Turkey Tail Liquid Extract\"\u003eTurkey Tail Mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eThe Turkey Tail mushroom is mainly consumed to regulate the immune system. However, more recent research is also showing evidence that the mushroom may have the ability of modulating the composition of the human microbiome [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25006989\" target=\"_blank\" title=\"Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial\" rel=\"noopener noreferrer\"\u003e19\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23435630\" target=\"_blank\" title=\"Trametes versicolor extract modifies human fecal microbiota composition in vitro.\" rel=\"noopener noreferrer\"\u003e20]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/shiitake-mushroom-liquid-extract\" title=\"Buy Shiitake Liquid Extract\"\u003eShiitake mushroom\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eShiitake mushrooms have been utilised for their anti-sclerotic (reduce hardening of arteries) activities as well as helping to reduce damage from UV light and helping to increase the renewal process of the skin, therefore this mushroom could be considered as an effective anti-photoaging and skin care ingredient \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-6382-5_16\" target=\"_blank\" title=\"L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms\" rel=\"noopener noreferrer\"\u003e[21,\u003c\/a\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/285138045_l-Ergothioneine_Protects_Skin_Cells_against_UV-Induced_Damage-A_Preliminary_Study\" target=\"_blank\" title=\"l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study\" rel=\"noopener noreferrer\"\u003e 22,\u003c\/a\u003e \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1319562X16000231\" target=\"_blank\" title=\"Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality\" rel=\"noopener noreferrer\"\u003e23]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eLearn more about our mushrooms by browsing our range of liquid mushroom extracts below or click \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003ehere\u003c\/u\u003e\u003c\/a\u003e to read our latest blogs on these fantastic fungi!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2] Choi, J.-H. (2018). Biologically functional molecules from mushroom-forming fungi. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eBioscience, Biotechnology, and Biochemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 82(3), pp.372–382.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Ying, C.-C. (1989). \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eIcons of medicinal fungi from China\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Beijing, China: Science Press.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [8] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eExperimental and Therapeutic Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 12(1), pp.513–517.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[9] Das, S.K., Masuda, M., Sakurai, A. and Sakakibara, M. (2010). Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eFitoterapia\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 81(8), pp.961–968.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[10] Ko and Leung. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[11] Gamage, S., Nakayama, J., Fuyuno, Y. and Ohga, S. (2018). The Effect of the Hot Water Extracts of the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePaecilomyces hepiali \u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003eand \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCordyceps militaris\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e Mycelia on the Growth of Gastrointestinal Bacteria. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdvances in Microbiology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 08(07), pp.490–505.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[12] Kim, S.B., Ahn, B., Kim, M., Ji, H.-J., Shin, S.-K., Hong, I.P., Kim, C.Y., Hwang, B.Y. and Lee, M.K. (2014). Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 151(1), pp.478–484.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [13] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[14] Cilerdzic, J., Stajic, M. and Vukojevic, J. (2016). Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCurrent Pharmaceutical Biotechnology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(3), pp.275–282.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[15] Wang, C.-H., Hsieh, S.-C., Wang, H.-J., Chen, M.-L., Lin, B.-F., Chiang, B.-H. and Lu, T.-J. (2014). Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 62(3), pp.634–641.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[16] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[17] Cui, X.-Y., Cui, S.-Y., Zhang, J., Wang, Z.-J., Yu, B., Sheng, Z.-F., Zhang, X.-Q. and Zhang, Y.-H. (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 139(3), pp.796–800.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[18] Pallav, K., Dowd, S.E., Villafuerte, J., Yang, X., Kabbani, T., Hansen, J., Dennis, M., Leffler, D.A., Newburg, D.S. and Kelly, C.P. (2014). Effects of polysaccharopeptide fromTrametes Versicolorand amoxicillin on the gut microbiome of healthy volunteers. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eGut Microbes\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 5(4), pp.458–467.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[19] Yu, Z.-T., Liu, B., Mukherjee, P. and Newburg, D.S. (2013). Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePlant Foods for Human Nutrition\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 68(2), pp.107–112\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[20] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eNachimuthu S., Kandasamy R., Ponnusamy R., Deruiter J., Dhanasekaran M., Thilagar S. (2019) L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms. In: Agrawal D., Dhanasekaran M. (eds) Medicinal Mushrooms. Springer, Singapore\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[21] Bazela, K., Solyga-Zurek, A., Debowska, R., Rogiewicz, K., Bartnik, E. and Eris, I. (2014). l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCosmetics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 1(1), pp.51–60.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[22] Rahman, M. A., Abdullah, N., \u0026amp; Aminudin, N. (2016). Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality. Saudi Journal of Biological Sciences. doi:10.1016\/j.sjbs.2016.01.021\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c\/details\u003e","published_at":"2019-02-25T22:45:41+11:00","sort_order":"best-selling","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-03T21:01:43+10:00","alt":"","width":2657,"height":2657,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/Reishi_Liquid_Extract.jpg?v=1561725306"}},{"id":81919148101,"handle":"our-most-popular-products","title":"Our most popular products","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2018-10-09T20:31:53+11:00","sort_order":"manual","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-09T21:38:37+11:00","alt":"","width":1000,"height":1061,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/mushroom-box-grown_9f7cd2ae-9917-4975-be1f-7e05481b2d9d.jpg?v=1539081517"}},{"id":150889955397,"handle":"life-cykel-specials","title":"Specials","updated_at":"2019-11-12T11:40:03+11:00","body_html":"Check in here for special deals and discounts on our range of products and bundles!","published_at":"2019-09-23T13:52:32+10:00","sort_order":"best-selling","template_suffix":"","disjunctive":false,"rules":[{"column":"tag","relation":"equals","condition":"specials"}],"published_scope":"web","image":{"created_at":"2019-09-23T13:56:04+10:00","alt":null,"width":2000,"height":1147,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/3.kits.horizontal.flowers.png?v=1569210964"}}]$139.80 AUD
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Mushroom Coffee
{"id":1974091022405,"title":"Mushroom Coffee","handle":"mushroom-coffee-2","description":"\u003cmeta charset=\"utf-8\"\u003e\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003e100% SMOOTH\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA smooth blend of coffee, Cordyceps and Chaga mushrooms, providing you with the health benefits of increased antioxidants, immunity and oxygen utilisation\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections\u003c\/strong\u003e: Add one tsp (3g) to 240ml of hot water, to drink black or white, with your choice of milk\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing size:\u003c\/strong\u003e One tsp (3g), once or twice daily\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eVegan friendly\u003c\/li\u003e\n\u003cli\u003eGluten free\u003c\/li\u003e\n\u003cli\u003eNon-GMO\u003c\/li\u003e\n\u003cli\u003ePacked in Australia from imported ingredients\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e Coffee Powder, Organic Chaga Extract, Organic \u003cem\u003eCordyceps militaris\u003c\/em\u003e extract\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a cool, dry place\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eAbout the mushrooms used:\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch3\u003eCHAGA\u003c\/h3\u003e\n\u003cp\u003eKnown as the king of mushrooms as it has the highest source of antioxidants gram for gram in the world 1 serve equalling 5 large cups of blueberries. Due to this its benefit on the immune system is profound, boosting or soothing as needed by your body. Chaga has a pleasant nutty, earthy taste, that grows on Siberian birch trees and is kind on the environment. Only the outer fruiting body is collected, leaving the mycelium whole and happy. High in zinc and potassium, Chaga’s alkalinity reduces the bitter taste of black coffee making it much smoother while also removing any digestive discomfort of plain coffee that some people suffer.\u003c\/p\u003e\n\u003ch3\u003eCORDYCEPS\u003c\/h3\u003e\n\u003cp\u003eVery popular with athletes particularly those in endurance categories. Commonly used as a pre workout as it increases our V02 max and the ability for the body to uptake oxygen. At the same time it is known as an adaptogen helping support the immune system during times of stress. It really is perfect for those needing extra energy whether it be during sport or a long day at work. The flavour of cordyceps is mild and creamy.\u003c\/p\u003e\n\u003cp\u003e* These statements have not been evaluated by the Food and Drug Administration or the Therapeutic Goods of Australia. These products are not intended to diagnose, treat, cure, or prevent any disease*\u003c\/p\u003e","published_at":"2019-04-15T15:26:00+10:00","created_at":"2018-12-14T17:27:18+11:00","vendor":"Life Cykel","type":"","tags":["Coffee","Cordyceps","Mushroom","Mushroom Coffee","Mushroom Drink"],"price":2195,"price_min":2195,"price_max":2195,"available":false,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":18807950999621,"title":"40g","option1":"40g","option2":null,"option3":null,"sku":"MC40G","requires_shipping":true,"taxable":false,"featured_image":{"id":5672427061317,"product_id":1974091022405,"position":1,"created_at":"2018-12-14T17:27:37+11:00","updated_at":"2019-04-15T15:26:00+10:00","alt":null,"width":4404,"height":2936,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Mushroom_Coffee.jpg?v=1555305960","variant_ids":[18807950999621]},"available":false,"name":"Mushroom Coffee - 40g","public_title":"40g","options":["40g"],"price":2195,"weight":40,"compare_at_price":null,"inventory_management":"shopify","barcode":"797776553105"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Mushroom_Coffee.jpg?v=1555305960","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Drink_Range_1aa23114-217c-4421-86d3-408326e8c4ae.jpg?v=1555305960"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/Mushroom_Coffee.jpg?v=1555305960","options":["Size"],"content":"\u003cmeta charset=\"utf-8\"\u003e\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003e100% SMOOTH\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA smooth blend of coffee, Cordyceps and Chaga mushrooms, providing you with the health benefits of increased antioxidants, immunity and oxygen utilisation\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections\u003c\/strong\u003e: Add one tsp (3g) to 240ml of hot water, to drink black or white, with your choice of milk\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing size:\u003c\/strong\u003e One tsp (3g), once or twice daily\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eVegan friendly\u003c\/li\u003e\n\u003cli\u003eGluten free\u003c\/li\u003e\n\u003cli\u003eNon-GMO\u003c\/li\u003e\n\u003cli\u003ePacked in Australia from imported ingredients\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eINGREDIENTS:\u003c\/strong\u003e Coffee Powder, Organic Chaga Extract, Organic \u003cem\u003eCordyceps militaris\u003c\/em\u003e extract\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a cool, dry place\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eAbout the mushrooms used:\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch3\u003eCHAGA\u003c\/h3\u003e\n\u003cp\u003eKnown as the king of mushrooms as it has the highest source of antioxidants gram for gram in the world 1 serve equalling 5 large cups of blueberries. Due to this its benefit on the immune system is profound, boosting or soothing as needed by your body. Chaga has a pleasant nutty, earthy taste, that grows on Siberian birch trees and is kind on the environment. Only the outer fruiting body is collected, leaving the mycelium whole and happy. High in zinc and potassium, Chaga’s alkalinity reduces the bitter taste of black coffee making it much smoother while also removing any digestive discomfort of plain coffee that some people suffer.\u003c\/p\u003e\n\u003ch3\u003eCORDYCEPS\u003c\/h3\u003e\n\u003cp\u003eVery popular with athletes particularly those in endurance categories. Commonly used as a pre workout as it increases our V02 max and the ability for the body to uptake oxygen. At the same time it is known as an adaptogen helping support the immune system during times of stress. It really is perfect for those needing extra energy whether it be during sport or a long day at work. The flavour of cordyceps is mild and creamy.\u003c\/p\u003e\n\u003cp\u003e* These statements have not been evaluated by the Food and Drug Administration or the Therapeutic Goods of Australia. These products are not intended to diagnose, treat, cure, or prevent any disease*\u003c\/p\u003e"} [{"id":80372269125,"handle":"frontpage","title":"Home page","updated_at":"2019-11-12T10:05:01+11:00","body_html":"","published_at":"2018-10-01T12:48:52+10:00","sort_order":"best-selling","template_suffix":"","published_scope":"web"},{"id":80833282117,"handle":"musroom-drink-mixes","title":"Mushroom Drink Mixes","updated_at":"2019-11-12T10:05:01+11:00","body_html":"Enrich your life with the goodness of medicinal mushrooms. Our mushroom drink mixes are making it easy for you to add mushrooms to your daily routine in a delicious way. Choose from Cacao Reishi, Lion's Mane Latte or Mushroom Coffee with Chaga and Cordyceps.","published_at":"2018-10-03T16:55:36+10:00","sort_order":"best-selling","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-03T17:07:25+10:00","alt":"","width":1084,"height":722,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/Screen_Shot_2018-10-03_at_5.01.14_PM.JPG?v=1545219242"}},{"id":81919148101,"handle":"our-most-popular-products","title":"Our most popular products","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2018-10-09T20:31:53+11:00","sort_order":"manual","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-09T21:38:37+11:00","alt":"","width":1000,"height":1061,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/mushroom-box-grown_9f7cd2ae-9917-4975-be1f-7e05481b2d9d.jpg?v=1539081517"}}]$21.95 AUD
Lion's Mane Mushroom Powder
{"id":1660586229829,"title":"Lion's Mane Mushroom Powder","handle":"lions-mane-mushroom-drinks-powder","description":"\u003cdiv class=\"woocommerce-product-details__short-description\"\u003e\n\u003cdiv class=\"woocommerce-product-details__short-description\"\u003e\n\u003ch3\u003eReach The Peak With Lion’s Mane Mushroom Powder\u003c\/h3\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane\u003c\/span\u003e \u003cspan style=\"font-weight: 400;\"\u003emushroom\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e has one of the most unique appearances in the \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eFungi\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e Kingdom, with white coral-like structures that resemble a \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27588730\" target=\"_blank\" title=\"Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides.\" rel=\"noopener noreferrer\"\u003e [1]\u003c\/a\u003e. This \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003emushroom powder\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e has been used in China for many centuries and is ingrained into their traditional medicine due to the wide variety of health benefits it provides \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Neurotrophic+Properties+of+the+Lion%E2%80%99s+Mane+Medicinal+Mushroom%2C+Hericium+erinaceus+(Higher+Basidiomycetes)+from+Malaysia.\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia\" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane mushroom\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e is commonly known for its bioactive compounds that are thought to improve cognitive ability, by supporting neural growth, antioxidant activity and reduce inflammation [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27588730\" target=\"_blank\" title=\"Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides.\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Neurotrophic+Properties+of+the+Lion%E2%80%99s+Mane+Medicinal+Mushroom%2C+Hericium+erinaceus+(Higher+Basidiomycetes)+from+Malaysia.\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia\" rel=\"noopener noreferrer\"\u003e2\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26244378\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" rel=\"noopener noreferrer\"\u003e3,\u003c\/a\u003e \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=The+Anti-Inflammatory+Effects+of+Lion%E2%80%99s+Mane+Culinary-Medicinal+Mushroom%2C+Hericium+erinaceus+(Higher+Basidiomycetes)+in+a+Coculture+System+of+3T3-L1+Adipocytes+and+RAW264+Macrophages\" target=\"_blank\" title=\"The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\" rel=\"noopener noreferrer\"\u003e4]\u003c\/a\u003e. The \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003emushroom\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e is also said to improve sleep quality and mood (listen \u003c\/span\u003e\u003ca href=\"https:\/\/podcasts.apple.com\/us\/podcast\/mushrooms-are-your-new-anti-aging-strategy-life-cykel-603\/id451295014?i=1000442712896\" target=\"_blank\" title=\"Mushroom podcast with Dave Asprey\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"font-weight: 400;\"\u003ehere\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e to biohacker Dave Asprey talk mushrooms) \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=The+Anti-Inflammatory+Effects+of+Lion%E2%80%99s+Mane+Culinary-Medicinal+Mushroom%2C+Hericium+erinaceus+(Higher+Basidiomycetes)+in+a+Coculture+System+of+3T3-L1+Adipocytes+and+RAW264+Macrophages\" target=\"_blank\" title=\" Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities\" rel=\"noopener noreferrer\"\u003e[5\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31118969\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? \" rel=\"noopener noreferrer\"\u003e6]\u003c\/a\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOur \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane mushroom powder\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e contains \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane mushroom extract\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e, for you to readily access all the \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003emushroom\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e goodness\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eDoes \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane mushroom powder\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e sound like the perfect supplement to add to your diet\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e? \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eNow you can easily feed your brain with Life Cykel’s \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane Mushroom Powder\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e or if you are feeling a bit more adventurous, why not try our \u003c\/span\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/lions-mane-mushroom-maca-carob-hemp-drinks\" title=\"Buy Lion's Mane Maca Mushroom Drink\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e Maca \u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003emushroom\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e drink\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eTo delve deeper into the world of fungi and to learn more about \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane mushrooms\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e and other functional mushrooms, follow this \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003elink\u003c\/span\u003e \u003cspan style=\"font-weight: 400;\"\u003eto read our latest \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003eblogs \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections: \u003c\/strong\u003eAdd one tsp (3g) to 240ml hot water, coffee, smoothies or to your desired recipe\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 1tsp (3g), once or twice daily.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eVegan friendly \u003c\/li\u003e\n\u003cli\u003eGluten free\u003c\/li\u003e\n\u003cli\u003eNon-GMO\u003c\/li\u003e\n\u003cli\u003ePacked in Australia from imported ingredients\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eIngredients:\u003c\/strong\u003e Lion’s Mane Mushroom 10:1 Dual Extract Powder.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e \u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e*These statements have not been evaluated by the TGA. This product is not intended to diagnose, treat, cure or prevent any disease.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\" mce-data-marked=\"1\"\u003eMushroom Research\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eWittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2]\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [4] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eWasser, S.P. (2017). Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 19(4), pp.279–317.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Vigna, L., Morelli, F., Agnelli, G.M., Napolitano, F., Ratto, D., Occhinegro, A., Di Iorio, C., Savino, E., Girometta, C., Brandalise, F. and Rossi, P. (2019). Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eEvidence-Based Complementary and Alternative Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 2019, pp.1–12.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","published_at":"2018-10-01T12:57:09+10:00","created_at":"2018-10-03T15:11:26+10:00","vendor":"Life Cykel","type":"","tags":[],"price":2995,"price_min":2995,"price_max":4995,"available":true,"price_varies":true,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":15202697609285,"title":"50g","option1":"50g","option2":null,"option3":null,"sku":"OLMMP50G","requires_shipping":true,"taxable":false,"featured_image":{"id":5672326856773,"product_id":1660586229829,"position":3,"created_at":"2018-12-14T17:14:00+11:00","updated_at":"2019-03-07T13:57:22+11:00","alt":null,"width":4877,"height":3251,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/50g_Lion_s_Mane_Powder.jpg?v=1551927442","variant_ids":[15202697609285]},"available":true,"name":"Lion's Mane Mushroom Powder - 50g","public_title":"50g","options":["50g"],"price":2995,"weight":98,"compare_at_price":null,"inventory_management":"shopify","barcode":"735850088228"},{"id":15202697642053,"title":"100g","option1":"100g","option2":null,"option3":null,"sku":"OLMMP100G","requires_shipping":true,"taxable":false,"featured_image":{"id":5672328724549,"product_id":1660586229829,"position":2,"created_at":"2018-12-14T17:14:13+11:00","updated_at":"2019-03-07T13:57:22+11:00","alt":null,"width":4877,"height":3251,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/100g_Lion_s_Mane_Powder.jpg?v=1551927442","variant_ids":[15202697642053]},"available":true,"name":"Lion's Mane Mushroom Powder - 100g","public_title":"100g","options":["100g"],"price":4995,"weight":165,"compare_at_price":null,"inventory_management":"shopify","barcode":"735850088235"}],"images":["\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/100g_50g_Lion_s_Mane_Powder.jpg?v=1551927442","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/100g_Lion_s_Mane_Powder.jpg?v=1551927442","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/50g_Lion_s_Mane_Powder.jpg?v=1551927442","\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/lion_s_mane_mushroom.jpg?v=1551927442"],"featured_image":"\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/products\/100g_50g_Lion_s_Mane_Powder.jpg?v=1551927442","options":["Size"],"content":"\u003cdiv class=\"woocommerce-product-details__short-description\"\u003e\n\u003cdiv class=\"woocommerce-product-details__short-description\"\u003e\n\u003ch3\u003eReach The Peak With Lion’s Mane Mushroom Powder\u003c\/h3\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane\u003c\/span\u003e \u003cspan style=\"font-weight: 400;\"\u003emushroom\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e has one of the most unique appearances in the \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eFungi\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e Kingdom, with white coral-like structures that resemble a \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27588730\" target=\"_blank\" title=\"Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides.\" rel=\"noopener noreferrer\"\u003e [1]\u003c\/a\u003e. This \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003emushroom powder\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e has been used in China for many centuries and is ingrained into their traditional medicine due to the wide variety of health benefits it provides \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Neurotrophic+Properties+of+the+Lion%E2%80%99s+Mane+Medicinal+Mushroom%2C+Hericium+erinaceus+(Higher+Basidiomycetes)+from+Malaysia.\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia\" rel=\"noopener noreferrer\"\u003e[2]\u003c\/a\u003e. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane mushroom\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e is commonly known for its bioactive compounds that are thought to improve cognitive ability, by supporting neural growth, antioxidant activity and reduce inflammation [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27588730\" target=\"_blank\" title=\"Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides.\" rel=\"noopener noreferrer\"\u003e1\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Neurotrophic+Properties+of+the+Lion%E2%80%99s+Mane+Medicinal+Mushroom%2C+Hericium+erinaceus+(Higher+Basidiomycetes)+from+Malaysia.\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia\" rel=\"noopener noreferrer\"\u003e2\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26244378\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds\" rel=\"noopener noreferrer\"\u003e3,\u003c\/a\u003e \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=The+Anti-Inflammatory+Effects+of+Lion%E2%80%99s+Mane+Culinary-Medicinal+Mushroom%2C+Hericium+erinaceus+(Higher+Basidiomycetes)+in+a+Coculture+System+of+3T3-L1+Adipocytes+and+RAW264+Macrophages\" target=\"_blank\" title=\"The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\" rel=\"noopener noreferrer\"\u003e4]\u003c\/a\u003e. The \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003emushroom\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e is also said to improve sleep quality and mood (listen \u003c\/span\u003e\u003ca href=\"https:\/\/podcasts.apple.com\/us\/podcast\/mushrooms-are-your-new-anti-aging-strategy-life-cykel-603\/id451295014?i=1000442712896\" target=\"_blank\" title=\"Mushroom podcast with Dave Asprey\" rel=\"noopener noreferrer\"\u003e\u003cspan style=\"font-weight: 400;\"\u003ehere\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e to biohacker Dave Asprey talk mushrooms) \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=The+Anti-Inflammatory+Effects+of+Lion%E2%80%99s+Mane+Culinary-Medicinal+Mushroom%2C+Hericium+erinaceus+(Higher+Basidiomycetes)+in+a+Coculture+System+of+3T3-L1+Adipocytes+and+RAW264+Macrophages\" target=\"_blank\" title=\" Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities\" rel=\"noopener noreferrer\"\u003e[5\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31118969\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? \" rel=\"noopener noreferrer\"\u003e6]\u003c\/a\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOur \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane mushroom powder\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e contains \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane mushroom extract\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e, for you to readily access all the \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003emushroom\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e goodness\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cdetails open=\"\"\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eDoes \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane mushroom powder\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e sound like the perfect supplement to add to your diet\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e? \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eNow you can easily feed your brain with Life Cykel’s \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane Mushroom Powder\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e or if you are feeling a bit more adventurous, why not try our \u003c\/span\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/lions-mane-mushroom-maca-carob-hemp-drinks\" title=\"Buy Lion's Mane Maca Mushroom Drink\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e Maca \u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003emushroom\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e drink\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eTo delve deeper into the world of fungi and to learn more about \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eLion’s Mane mushrooms\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e and other functional mushrooms, follow this \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003elink\u003c\/span\u003e \u003cspan style=\"font-weight: 400;\"\u003eto read our latest \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003eblogs \u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections: \u003c\/strong\u003eAdd one tsp (3g) to 240ml hot water, coffee, smoothies or to your desired recipe\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eServing Size:\u003c\/strong\u003e 1tsp (3g), once or twice daily.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eVegan friendly \u003c\/li\u003e\n\u003cli\u003eGluten free\u003c\/li\u003e\n\u003cli\u003eNon-GMO\u003c\/li\u003e\n\u003cli\u003ePacked in Australia from imported ingredients\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eIngredients:\u003c\/strong\u003e Lion’s Mane Mushroom 10:1 Dual Extract Powder.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e \u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e*These statements have not been evaluated by the TGA. This product is not intended to diagnose, treat, cure or prevent any disease.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\" mce-data-marked=\"1\"\u003eMushroom Research\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eWittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2]\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [4] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eWasser, S.P. (2017). Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 19(4), pp.279–317.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[6] Vigna, L., Morelli, F., Agnelli, G.M., Napolitano, F., Ratto, D., Occhinegro, A., Di Iorio, C., Savino, E., Girometta, C., Brandalise, F. and Rossi, P. (2019). Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eEvidence-Based Complementary and Alternative Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 2019, pp.1–12.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/details\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e"} [{"id":92048490565,"handle":"all","title":"All","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2019-02-18T10:20:43+11:00","sort_order":"best-selling","template_suffix":"","disjunctive":false,"rules":[{"column":"variant_price","relation":"greater_than","condition":"0"},{"column":"variant_inventory","relation":"greater_than","condition":"0"},{"column":"type","relation":"not_equals","condition":"Insurance"}],"published_scope":"web"},{"id":80372269125,"handle":"frontpage","title":"Home page","updated_at":"2019-11-12T10:05:01+11:00","body_html":"","published_at":"2018-10-01T12:48:52+10:00","sort_order":"best-selling","template_suffix":"","published_scope":"web"},{"id":80835444805,"handle":"other-products","title":"More Products","updated_at":"2019-11-12T10:05:01+11:00","body_html":"","published_at":"2018-10-03T17:18:17+10:00","sort_order":"best-selling","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-03T17:19:34+10:00","alt":"","width":3240,"height":3240,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/Keep_Cup_3.png?v=1538551174"}},{"id":80835018821,"handle":"mushroom-powders","title":"Mushroom Powders","updated_at":"2019-11-11T16:45:01+11:00","body_html":"\u003ch1\u003eMushroom Powder as a Dietary Supplement\u003c\/h1\u003e\n\u003cp\u003eDried organic mushrooms in a pure mushroom powder form to easily add to your daily drinks and recipes. The use of pure mushroom powder dates centuries ago. Primarily used in traditional eastern medicine, mushroom powders were considered a powerful treatment due to their great nutritional value and additional beneficial properties \u003ca href=\"https:\/\/pdfs.semanticscholar.org\/f7b4\/834d5a9c43bf507d04f3e4879ab3262e6de2.pdf\" target=\"_blank\" title=\"Nutritional and medicinal importance of mushrooms\" rel=\"noopener noreferrer\"\u003e[1]\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003ePositive experiences from mushroom powders resulted in increased interest in several specific types of fungi: Reishi, Lion’s Mane and Cordyceps mushrooms. The potential power of these mushroom powders is to support the functions of the human body and to have the ability to improve vital processes, which has gained them their modern nickname - \u003cstrong\u003e\u003cem\u003ethe functional \u003c\/em\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cem\u003emushrooms \u003ca href=\"https:\/\/pdfs.semanticscholar.org\/f7b4\/834d5a9c43bf507d04f3e4879ab3262e6de2.pdf\" target=\"_blank\" title=\"Nutritional and medicinal importance of mushrooms\" rel=\"noopener noreferrer\"\u003e[1\u003c\/a\u003e,\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09168451.2018.1431519?journalCode=tbbb20\" target=\"_blank\" title=\"Biologically functional molecules from mushroom-forming fungi\" rel=\"noopener noreferrer\"\u003e 2]\u003c\/a\u003e.\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eUsing mushroom powders as a natural supplement in your dietary routine can result in an enhanced amount of valuable nutrition needed for your journey of health and wellness.\u003c\/p\u003e\n\u003cdetails\u003e\u003csummary\u003eRead More\u003c\/summary\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/lions-mane-mushroom-drinks-powder\" title=\"Buy Lion's Mane Mushroom Powder\"\u003eLion’s Mane Mushroom Powder\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eLion's Mane Mushroom is known for its positive effects on cognitive health \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=).+Neurotrophic+Properties+of+the+Lion%E2%80%99s+Mane+Medicinal+Mushroom%2C+Hericium+erinaceus+(Higher+Basidiomycetes)+from+Malaysia\" target=\"_blank\" title=\"Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia\" rel=\"noopener noreferrer\"\u003e[3]\u003c\/a\u003e. The mushroom is seen to enhance physiological activities, such as antioxidant and anti- inflammatory activities\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=The+Role+of+Culinary-Medicinal+Mushrooms+on+Human+Welfare+with+a+Pyramid+Model+for+Human+Health\" target=\"_blank\" title=\"The role of culinary-medicinal mushrooms on human welfare with a pyramid model for human health.\" rel=\"noopener noreferrer\"\u003e [5\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Chemistry%2C+Nutrition%2C+and+Health-Promoting+Properties+ofHericium+erinaceus(Lion%E2%80%99s+Mane)+Mushroom+Fruiting+Bodies+and+Mycelia+and+Their+Bioactive+Compounds\" target=\"_blank\" title=\"Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds.\" rel=\"noopener noreferrer\"\u003e6\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26559695\" target=\"_blank\" title=\"The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages\" rel=\"noopener noreferrer\"\u003e7\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Comparative+studies+on+extracts+from+Hericium+erinaceus+by+different+polarity+reagents+to+gain+higher+antioxidant+activitie\" target=\"_blank\" title=\"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities.\" rel=\"noopener noreferrer\"\u003e8\u003c\/a\u003e] and neural growth \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Corallocins+A%E2%80%93C%2C+Nerve+Growth+and+Brain-De\" target=\"_blank\" title=\"Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides.\" rel=\"noopener noreferrer\"\u003e[4]\u003c\/a\u003e, improving memory and focus as well as enhancing your dreams and mood [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Hericium+erinaceus+Improves+Mood+and+Sleep+Disorders+in+Patients+Affected+by+Overweight+or+Obesity%3A+Could+Circulating+Pro-BDNF+and+BDNF+Be+Potential+Biomarkers\" target=\"_blank\" title=\"Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?\" rel=\"noopener noreferrer\"\u003e9]\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/cordyceps-mushroom-powder-organic-free-shipping\" title=\"Buy Cordyceps Mushroom Powder\"\u003eCordyceps Mushroom Powder\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eCordyceps mushroom shows to promote anti-inflammatory, anti-microbial and anti-oxidative activities (anti-ageing) [\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0367326X10001863\" target=\"_blank\" title=\"Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects\" rel=\"noopener noreferrer\"\u003e10\u003c\/a\u003e, \u003ca href=\"https:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=86265\" target=\"_blank\" title=\" Abstract Full-Text HTML XML Download Download as PDF (Size:624KB) PP. 490-505 DOI: 10.4236\/aim.2018.87034 417 Downloads 816 Views Author(s) Leave a commentSanath Gamage1, Jiro Nakayama2, Yusuke Fuyuno2, Shoji Ohga1Affiliation(s) 1Department of Agro-Environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan. 2Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan. ABSTRACT The gastrointestinal health is very important aspect concerning human health. It refers to nutrient and vitamin absorption, food digestion and various infectious diseases. The Paecilomyces hepiali and Cordyceps militaris are highly enriched with cordycepin and ergosterol which are considered as anti bacterial substances. Present study finds out comparative effect of hot water extract of particular fungal material on growth of six species of gastrointestinal bacteria that belong to both aerobic and anaerobic and, consist with harmful and commensal categories. The appropriate concentration level of hot water extract of both strains was identified. The individual specific bacterial growing media were prepared and calculated; amounts of bacteria cultures were inoculated by using micro pipettes. The optical density and number of bacterial colonies were measured after 24 hours. The pure mycelial extract of P. hepiali with 2 × 10-3 g\/ml of concentration has significant effect on depleting the growth of E. coli, E. faecalis, S. aureus, L. gasseri and B. ovatus bacteria. B. longum has no significant effect by particular extract. Same type of extract of C. militaris has significantly reduced the growth of every bacteria used in this study. Hot water extract of C. militaris cultivated on soy bean has significant growth retardation toward E. coli, E. faecalis, S. aureus and L. gasseri. It has stimulated the growth of B. ovatus and B. longum which are considered as beneficial bacteria for human gut. This study shows that extracts of both mycelia include antimicrobial substances like cordycepin and ergosterol which can be used as food supplements to enhance human gut health. KEYWORDS Ophiocordyceps sinensis , Cordyceps militaris , Antibacterial Activity, Human Gut Bacteria 1. IntroductionThe wild Ophiocordyceps sinensis and Cordyceps militaris are important kind of medicinal fungi belonging to the phylum Ascomycota. Those are an abundant resource in nature with various biological activities and have been used extensively as a tonic and health supplement [1] . Chioza et al. reported that Paecilomyces hepiali and Hirsutella sinensis do coexist in O. sinensis. They found DNA of these fungi in both the caterpillar and fruiting bodies of natural O. sinensis. However, those isolates commonly exist in natural O. sinensis as a result of being endoparasites or epiphytes of the host insect [2] . In this study, P. hepiali and C. militaris have been used to prepare mycelial hot water extract.O. sinensis is a macro fungus of biomedical importance, contains a number of bioactive components. Many of them are biological response modifiers which activate our immune systems for a multitude of defensive functions. The immunomodulating effects are associated with its antitumor activity [1] and lower fasting plasma levels of glucose and insulin improve oral glucose tolerance, and increase glucose-insulin index [3] . Extract of O. sinensis has inhibited hepatic fibrogenesis [4] in rats with CCl4-induced liver fibrosis and reduced the weight loss, polydipsia, and hyperglycemia in streptozotocin-induced diabetic rats [5] . The water extract of C. militaris has reduced fasting serum glucose level and enhanced glucose utilization in skeletal muscles and improved insulin secretion in rats [6] . The bioactive constituents of particular fungus have been extracted such as cordycepin, polysaccharides, ergosterol, mannitol, and adenosine [7] [8] . Meanwhile, various pharmacological actions of these chemical constituents have been reported, including antitumor effect, antioxidant, nephroprotective, antiapoptotic, antibacterial properties and inflammatory effects [1] which are the most proverbial effect of O. sinensis and C. militaris.The effect of O. sinensis and C. militaris may be caused by a single active ingredient or by the combined action of many active agents that existed in the extractions. Research is necessary to get an overview about the genus Ophiocordyceps and Cordyceps because of the increasing interest both for medicine and mycology [9] [10] . This study has been observed pharmacological actions of the P. hepiali and C. militaris for its significant role in the development of new drugs and therapeutics for various bacterial diseases.Gastrointestinal BacteriaColonization of the gastrointestinal tract of newborn infants starts immediately after birth and occurs within a few days. Pioneer bacteria can modulate expression of genes in host epithelial cells [11] thus creating a favorable habitat for themselves, and can prevent growth of other bacteria introduced later in the ecosystem. The composition of the gut bacteria community in the stomach and colon is distinctive, which is mainly due to different physicochemical conditions, such as intestinal motility, pH value, redox condition, nutrients and host secretions. Additionally, they can be influenced by many factors, such as the use of antibiotics, illness, stress, aging, bad dietary habits and lifestyle [12] [13] .Generally around 400 species of bacteria have evolved and adapted to live and grow in the human intestine. The large intestine contains a complex and dynamic microbial ecosystem with high densities of living bacteria, which achieve concentrations of up to 1011 or 1012 cells\/g of luminal contents [14] . The genera Bacteroides, Bifidobacterium, Eubacterium, Clostridium, Peptococcus, Peptostreptococcus, and Ruminococcus are predominant in human beings, whereas aerobes (facultative anaerobes) such as Escherichia, Enterobacter, Enterococcus, Klebsiella, Lactobacillus, Proteus, etc. are among the subdominant genera [15] . Bacteria can supply essential nutrients, synthesize vitamin K, aid in the digestion of cellulose, and promote angiogenesis and enteric nerve function. They produce a wide spectrum of enzymes that, being reductive and hydrolytic in nature, are actively involved in many processes in the colon, such as carbohydrate and protein fermentation, bile acid and steroid transformation, metabolism of xenobiotic substances, as well as the activation and destruction of potential mutagenic metabolites [12] [16] . Nitroreductase, azoreductase, N-oxide and sulfoxide reductase are the most extensively investigated reductive enzymes, while glucosidase and glucronidase are the most extensively studied hydrolytic enzymes [14] .Some of these bacteria are potential pathogens and can be a source of infection and sepsis under some circumstances for instance when the integrity of the bowel barrier is physically or functionally breached. However, the constant interaction between the host and its microbial guests can infer important health benefits to the human host. Other hand, management of microbiota in the gut is crucial specially reducing pathogenic bacteria [17] .This study has been focused on utilization of fungal material of O. sinensis and C. militaris as food supplements and evaluation of the antibacterial activities of six species of bacteria which are categorized as commensal and pathogenic have been done. The fungal extract or synthesized drug from particular fungi can be used as prebiotic for target bacteria or symbiotic with ameliorated bacteria strains and also used as a selective inhibitor towards harmful bacteria.2. Materials and Methods2.1. Fungal StrainThe P. hepiali strain which used in this study was originally brought from Jilin Agricultural University, China and assigned to accession number KUMB1081 and C. militaris assigned to accession number KUMB1061 in the mushroom culture bank at the Laboratory of Forest Production Control, Kyushu University.2.2. Bacterial StrainThe strains which have been used this experiment and the places where bacterial strains were originally brought have been shown in Table 1.2.3. Culture Condition and Media PreparationThe E. faecalis, S. aureus and E. coli were grown in LB broth (Difco) at 37˚C. Culture media of the E. coli was shaken to provide optimum growing condition. Other strains have been incubated at 37˚C. Colony counting was done by using agar powder (Waco) ameliorated LB broth. The L. gasseri, B. longum and B. ovatus have been cultured in GAM broth (Nissui) at 37˚C. Those strains have been provided anaerobiosis conditions by using anaeropack (Mitsubishi Gas Chemical Co., Inc.). The cell enumerations have been carried out on modified GAM media which agar powder (Waco) was ameliorated to the media (24 hours at 37˚C).Two different types of hot water extracts of both P. hepiali and C. militaris were prepared. Two flaks with 500 ml of potato dextrose broth (Difco) were prepared according to company instruction. Meanwhile, oil removed soy bean, wheat brand and distilled water were mixed at a ratio of 4:1:2 and put in to polypropylene bags. Both flaks and both bags were autoclaved at 121˚C for 30 minutes. After overnight cooling, a 5 mm diameter agar plugs with actively growing mycelium of both fungal strains were inoculated in to each potato dextrose broth and soy bean media. Those media were incubated under 25˚C for 20 days. Potato dextrose broth was used for obtain pure mycelia of both fungal strains. Day 20, both types of cultures have reached appropriate amount of mycelia. Liquid media were filtered (Advantec, 0.45 μm) and mycelial mats were collected. Mycelia were dried for 12 hours at 50˚C. From each strain, 5 g of pure mycelia were collected by following same method for few flasks and mycelia chopped by using electrical blender. When they broken in to small pieces, 500 ml of water was added and continue more few minutes. This mixture was boiled 3 hours and residual were filtered by using Advantec vacuum filter unit with 0.45 μm filter papers at first. Then 0.2 μm filter papers were used for obtaining more purified extract. Rotary evaporator was used to evaporate excess water from extract for concentrate the solution up to 2 × 10−3 g\/ml. Pycnometer (specific gravity bottle) method was used measuring the concentrations of the extracts. Then severalTable 1. Information of bacterial strains (accession number and origin).levels of concentrations were prepared by adding required amount of water. Both strains which were fully colonized on soy bean media were dried as above method and 50 g were collected. Compared to pure mycelia, soy bean media includes many substances which are removed at filtration process. That’s why 50 g of soy bean media was taken and they were broken in to small parts by using blender. Then 500 ml of water were added in to blender and continue more few minutes. Same procedure was continued for making concentrated hot water extract.2.4. Experiment Set up2.5. Statistical AnalysisThe analyses were done using Minitab 18 statistical software (Minitab Inc.) and Microsoft Excel. Identification of statistical differences within treatments was done by Analysis of Variance (ANOVA) followed by Tukey’s post hoc test. All the analyses were done with 0.05 significance levels. All graphs are presented with standard error bars.3. Results and DiscussionThe identification of antibacterial effect expressed by hot water extracts of both P. hepiali and C. militaris was done. The limited spectrum of antibacterial activity of the aqueous extracts has been compared with the control. It was hard to justify since all the extracts contained the metabolites, though not in the same proportions. As shown in Table 2, effective concentration of extract was evaluated for further experiment by using both aerobic and anaerobic bacterial strains. Nutritional requirements of higher fungi play critical role in production of mycelia in submerged cultures. It has been found that medium constituents strongly affect chemical composition, structure and productivity [19] [20] . Mycelial biomass is one of the useful product containing various bioactive compounds, production yield of mycelial biomass should be simultaneously considered in the processes of submerged culture of P. hepiali and C. militaris.3.1. Effect of Concentration Levels on Bacterial GrowthThe clue was given by the result shown in Table 2 that extract of P. hepiali has anti bacterial effect. The bacterial growth of E. coli and L. gasseri in every concentration level show less growth compared with its own controls in terms of optical density of 600 nm [13] [21] . Suggestion can be made as the extracts have one or more antibacterial compound that has been dissolved. It has been reported the active components of Cordyceps and O. sinensis are peptides, a glycoprotein, DNase [3] , adenosine, adenine, hypoxanthine, cordycepin [22] .The inner cellular material of the both mycelium of P. hepiali and C. militaris are important for inhibit bacterial growth. As expected, high concentration has high effect on bacterial growth inhibition. Both aerobic and anaerobic bacterial strains were responded with growth retardations. It has been reported that high concentration of extract provided significant effect on bacterial inhibition [23] . The concentration of 2 × 10−3 g\/ml has shown significantly lower bacterial growth compared with other low concentration levels in terms of OD 600 nm. In this study, 2 × 10−3 g\/ml of concentration has been used for further treatments.The bacterial growths of selected six types of bacteria in the presence of pure mycelial hot water extract of P. hepiali and C. militaris have been shown in Table 3. Control plots of each bacterial strain have been represented its growth without adding any extract.Table 2. This table represents four different concentration levels of pure mycelial extract of P. hepiali effect on two different bacterial strains. The values in last four columns represent every mean ± SD of OD 600 nm values measured at 24 hours after inoculations. Values in the same column and its own control column with different letters differ significantly according to Tukey’s test (p \u0026lt; 0.05).Table 3. This table represents the effect of pure mycelial hot water extracts of both P. hepiali and C. militaris on six different bacterial strains. The values in each column represent every mean ± SD of OD 600 nm values measured at 24 hours after inoculations. Values in the same row with different letters differ significantly according to Tukey’s test (p \u0026lt; 0.05).It has been reported that cordycepin mainly dissolved in submerged cultures [24] , referring to extract preparation of this study extracellular secretions in submerged culture has been filtered and completely wash away. The mycelia with remaining intracellular substances were used for extract preparation. It has been suggested that antibacterial substances can be found inner cellular part of mycelia as well. That might be cordycepin or ergosterol. As for the extracellular polysaccharides from mycelial cultures of Cordyceps, different constituents have been demonstrated according to species and culture conditions [24] [25] .3.2. Effect on Aerobic Bacterial GrowthEven though inside of gut consist with lack of oxygen environment, there are so many type of facultative anaerobes bacteria. The effects of pure mycelial hot water extracts of both P. hepiali and C. militaris on aerobic bacteria have been shown in Figure 1.The inhibition effect done by extract of both P. hepiali and C. militaris was not a selective effect on specific bacterial strain but the strength of inhibition was different among bacteria strain and between two extracts. Pure mycelial hot water extract of both P. hepiali and C. militaris have significant effect of bacterial growth inhibition towards E. coli, E. faecalis and S. aureus.3.3. Effect on Anaerobic Bacterial GrowthThe human gut accommodates hundred of anaerobic bacteria as well. Out of them, growth of three selected bacterial strain at the presence of hot water extracts of pure mycelia has been presented in Figure 2.The inhibition effect done by pure mycelial extracts of P. hepiali was represented a selective effect on specific bacteria. Particular extract has no anyFigure 1. This graph represents the effect of pure mycelial hot water extracts of both P. hepiali and C. militaris on three different aerobic bacterial strains. The values in each column represent every mean ± SD of OD 600 nm values measured at 24 hours after inoculations. The error bars represent standard error. Means values in the same bacterial strain that do not share a letter are significantly different according to Tukey’s test (p \u0026lt; 0.05).Figure 2. This graph represents the effect of pure mycelial hot water extracts of both P. hepiali and C. militaris on three different anaerobic bacterial strains. The values in each column represent every mean ± SD of OD 600 nm values measured at 24 hours after inoculations. The error bars represent standard error. Means values in the same bacterial strain that do not share a letter are significantly different according to Tukey’s test (p \u0026lt; 0.05).significant effect on growth inhibition of B. lonum strain. Meanwhile, extract of C. militaris has significnly inhibited bacterial growth of every selected strain in terms of OD 600 nm measurements.Even though extracellular polymeric substances washed away from pure mycelial hot water extract of both P. hepiali and C. militaris, when the mycelia submerged culture was filtered and cleaned, active compound has still been remained to inhibit bacterial growth. There were some extracellular polymeric substances which have strong biological activities as detected from fruiting bodies of Cordyceps [19] [20] . In this regard, much attention was given to prepare hot water extract with active compound from both extracellular and inner cellular parts and, soy bean solid growing media was selected.3.4. Effect on Bacterial Growth of Hot Water Extract of C. militaris Grown on Soy Bean MediaIt was generally accepted that mycelia of many different mushrooms and entomopathogenic fungi can be grown, to some extent, on a wide range of carbon sources [24] [26] . However, the nutriant source yielding maximum growth differs from species to species. C. militaris has been investigated in this study utilizing soy bean as the preferred major nutriant source. The omission of nitrogen in the medium greatly affects fungal growth and metabolite production. Nitrogen source may be supplied to media in the form of ammonia, nitrate, or as organic compounds, such as amino acids or proteins. In comparison with organic nitrogen sources, inorganic nitrogen sources often yield relatively lower mycelial biomass production than organic sources [27] [28] .The soybean steep powder and tryptone were more efficient for mycelial growth and also enhancements obtained from using the organic sources of nitrogen may indeed not only reflect the form that the nitrogen is in, but also the fact that other non nitrogen components could play a role in the improvements [29] .The bacterial strains which belong to aerobic and anaerobic categories were treated by hot water extract of C. militaris which has been cultivated on soy bean media. The growth inhibition effect was messured as OD 600 nm absorbtion and colony count method as shown in Table 4.As graphically shown in Figure 3, hot water extract of C. militaris cultivated on soy bean significantly effect on growth retardation of S. aureus, E. coli, E. faecalis and L. gasseri. Mean while, B. ovatus and B. longum have grown in hot water extract treated media at a high bacteria density compared to its controls.The colony count method was followed to obtain visual detection of the effect after optical density measurements. Colony count measurements of the bacterial cultures after 24 hours of inoculation have been presented in Figure 4. Serial dilution method was followed with 0.01 dilution factor. Hot water extract of C. militaris grown on soy bean has significant effect on growth retardation of S. aureus and E. coli. In terms of colony count there was no any significant growth retardation of bacterial strains of E. faecalis, L. gasseri, B. ovatus and B. longum.It has been identified that the active compounds as cordycepin and ergosterol which are correspondent to the antibacterial effect [13] . The cordycepin was firstTable 4. This table represents the effect of hot water extracts of C. militaris grown on soy bean media towards six different bacterial strains. The values in second and third columns represent every mean ± SD of OD 600 nm values and fourth and fifth columns represent every mean ± SD of colony count done at 24 hours after inoculations. Values of OD 600 and colony count share different letters with their own control are significantly different according to Tukey’s test (p \u0026lt; 0.05).Figure 3. This graph represents the effect of hot water extracts of C. militaris grown on soy bean media towards six different bacterial strains. The values in each column represent every mean ± SD of OD 600 nm values measured at 24 hours after inoculations. The error bars represent standard error. Means values in the same column that do not share a letter are significantly different according to Tukey’s test (p \u0026lt; 0.05).isolated from C. militaris and its structural formula was confirmed as 3'-deoxyadenosine [30] . Cordycepin is the most considerable adenosine analogue from some Cordyceps [31] , which is a derivative of the nucleoside adenosine. It was later found to be present in small amounts in O. sinensis. The cordycepin is a category of compounds that exhibits significant therapeutic potential and has many intracellular targets, including nucleic acid, apoptosis, and cell cycle. It has been reported that the variety of molecular mechanisms thatFigure 4. This figure represents the appearance and density of colonies of S. aureus and E. coli bacterial strains measured at 24 hours after inoculations. The effect of hot water extracts of C. militaris grown on soy bean media has been shown compared with colony growth of their own control. Dilution factor was 0.01 (10−2). Numbers on the dishes represented level of dilution (1). 10−4 folds dilution (2). 10−6 folds dilution (3). 10−8 folds dilution.mediate the pharmacological effects of cordycepin. Besides, they deem that cordycepin can participate in various molecular processes in cells because of its similarity with adenosine [8] . Cordycepin is a broad spectrum biocidal compound possessing not only antitumor activity but also antibacteria, antivirus, and insecticidal activities [9] . It was confirmed as a marker for C. militaris within the content profiles of nucleosides in Cordyceps product [32] . Cordycepin could be an attractive therapeutic candidate with oral activity against I\/R-associated heart diseases such as myocardial infarction [1] and also it is a potent anti-inflammatory and analgesic medicine [33] . Cordycepin can intensively regulate the functions of human immune cells in vitro [34] . It has stimulated the release of some cytokines of resting PBMCs and influenced proliferation of PBMCs and transcription factors in THP-1 cell line.The researchers have shown that cordycepin is generally present in solid substrate grown Cordyceps, but not in liquid cultured Cordyceps. The presence or absence of cordycepin is dependent upon many factors, including the method of mycelial culture [24] . In this study hot water extract of C. militaris grown on soy bean solid media has some sort of beneficial effect in terms of human gut health because compared with pure mycelial extract; soy bean extract has inhibited few harmful bacterial strains while stimulating beneficial bacterial growth.The ergosterol content in C. sinensis has been determined with HPLC method and high yield has been obtained. The ergosterol is a characteristic of fungi sterol, an important source of vitamin D2 and existed in free and combined states [35] . It is an important raw material in the production of steroid hormone drugs and food, feed, and pharmaceutical raw material [36] . The cytotoxicity and antimicrobial activity of ergosterol have been proven. It possesses weak cytotoxicity against HL-60 and BEL-7402 cell lines and moderate antimicrobial activity against the bacteria E. aerogenes and P. aeruginosa and the fungus C. albicans [12] . Genetically modified strains which biosynthesis high yield of ergosterol can be produced [37] .Adenosine is a major nucleoside in Cordyceps and plays an important role in biochemical process in the organism [1] . The content of adenosine is much higher in cultured C. sinensis than in the natural one. Among them, cultured C. sinensis has a large number of adenosines, which are much higher than those in cultured C. militaris [38] . Nucleotide named AMP can be degraded to adenosine and the source of inosine in natural C. sinensis may be the oxidative deamination of adenosine.The soy bean media which C. militaris has actively been grown or its hot water extract can be used as a prebiotic. Because it includes food ingredient that beneficially affects the host by selectively stimulating the growth, activity, or both of B. ovatus and B. longum bacterial species already resident in the colon. Moreover, fully colonized soy bean media of C. militaris can be used as method of synbiotics microflora management, in which probiotics and prebiotics are used in combination. C. militaris grown on soy bean media can be used for conjunction with B. ovatus and B. longum strains. This combination could improve the survival of the probiotic organism, because its specific substrate is readily available for its fermentation [39] . Among the various human intestinal microorganisms, bifidobacteria are often taken as useful indicators of human health under most environmental conditions, on the basis that they play important roles in metabolism such as amino acid and vitamin production, aid defense against infection, are associated with longevity, antitumor activity, pathogen inhibition, improvement of lactose tolerance of milk products, and immune potentiation.The selective growth inhibitors play important role of understanding of the biochemical or molecular mechanisms of the bacterial infection and prevention of human diseases. It would be desirable to both inhibit the growth of potential pathogens and increase the numbers of bifidobacteria in the human gut. Selective growth promoters for bifidobacteria or inhibitors for harmful bacteria are especially important for human health, because intake of these extract may normalize functions that result in the prevention of diseases caused by pathogens in the gastrointestinal tract [13] . However, human gastrointestinal tract is a complex and hostile environment, it appears unlikely that a few probiotic bacterial strain capable of influencing the microbial ecology of the host and of beneficially affecting lactose intolerance, the incidence of diarrhea, mucosal immune responses, blood cholesterol concentrations, and the induction of cancer.4. ConclusionThe P. hepiali and C. militaris derived materials intake would be expected to alter the growth and composition of the intestinal flora and modulate the genesis of potentially harmful agents, thus maintaining optimal human health. On the basis of our data and earlier findings, inhibitory action of hot water extracts of P. hepiali and C. militaris toward the S. aureus, E. coli, E. faecalis and L. gasseri used without any adverse effect on bifidobacteria used may be an indication of at least one of the pharmacological actions of P. hepiali and C. militaris. It is noteworthy that C. militaris has a more potent activity than the much more expensive C. sinensis. The natural resources of the P. hepiali and C. militaris are diminishing, and it is feasible to artificially cultivation of the fruiting bodies. Thus, it would be important to find out if both Cordyceps species possess similar activities. The bioactive constituents with potential therapeutic value which belongs to both P. hepiali and C. militaris should be isolated. Additionally, cordycepin may also have potential in the preservation of food and selective media for the propagation of bifidobacteria. New methods and technologies need to be adopted to extract and analyze the components, requiring evaluation along the modern scientific line. Discoveries are needed about these special creatures to harvest its value for development of mankind. More researches have to be made on the herbal-medicinal and therapeutic values of O. sinensis and C. militaris species.Conflicts of InterestThe authors declare no conflicts of interest regarding the publication of this paper.Conflicts of InterestThe authors declare no conflicts of interest.Cite this paper Gamage, S. , Nakayama, J. , Fuyuno, Y. and Ohga, S. (2018) The Effect of the Hot Water Extracts of the Paecilomyces hepiali and Cordyceps militaris Mycelia on the Growth of Gastrointestinal Bacteria. Advances in Microbiology, 8, 490-505. doi: 10.4236\/aim.2018.87034. References [1]\tLiu, Y., Wang, J., Wang, W., Zhang, H., Zhang, X. and Han, C. (2015) The Chemical Constituents and Pharmacological Actions of Cordyceps sinensis. 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Food Research International, 36, 895-904. https:\/\/doi.org\/10.1016\/S0963-9969(03)00098-X \" rel=\"noopener noreferrer\"\u003e12\u003c\/a\u003e], the mushroom also has beneficial effects on lipid metabolism [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24231073\" target=\"_blank\" title=\"Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice\" rel=\"noopener noreferrer\"\u003e11\u003c\/a\u003e] and improves your endurance to prolonged and high intensity exercise [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs\" rel=\"noopener noreferrer\"\u003e13\u003c\/a\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" target=\"_blank\" title=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17386115\" rel=\"noopener noreferrer\"\u003e,\u003c\/a\u003e \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27408987\" target=\"_blank\" title=\"Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation.\" rel=\"noopener noreferrer\"\u003e14\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=).+Effect+of+Polysaccharide+from+Cordyceps+militaris+(Ascomycetes)+on+Physical+Fatigue+Induced+by+Forced+Swimming\" target=\"_blank\" title=\"Effect of Polysaccharide from Cordyceps militaris (Ascomycetes) on Physical Fatigue Induced by Forced Swimming\" rel=\"noopener noreferrer\"\u003e15]\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003e\u003ca href=\"https:\/\/lifecykel.com\/products\/reishi-powder\" title=\"Buy Reishi Mushroom Powder\"\u003eReishi Mushroom Powder\u003c\/a\u003e\u003c\/h3\u003e\n\u003cp\u003eThe constituents within Reishi mushroom help to enhance anti-microbial, anti-oxidant and immunomodulating activities [\u003ca href=\"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.6b00973\" target=\"_blank\" title=\"Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids\" rel=\"noopener noreferrer\"\u003e16\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ingentaconnect.com\/content\/ben\/cpb\/2016\/00000017\/00000003\/art00010?crawler=true\" target=\"_blank\" title=\"Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents\" rel=\"noopener noreferrer\"\u003e17\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24386913\" target=\"_blank\" title=\"Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium\" rel=\"noopener noreferrer\"\u003e18\u003c\/a\u003e]. The mushroom is also well known for its beneficial effects on sleep and relaxation [\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24386913\" target=\"_blank\" title=\"Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium\" rel=\"noopener noreferrer\"\u003e18\u003c\/a\u003e, \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17383716\" target=\"_blank\" title=\"Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism\" rel=\"noopener noreferrer\"\u003e19\u003c\/a\u003e]. The positive experience of the usage of Reishi mushroom powder in Asian culture has helped Reishi become a symbol of longevity, balance and well-being of the mind, body and spirit.\u003c\/p\u003e\n\u003ch4\u003eMushroom Powder Dosage\u003c\/h4\u003e\n\u003cp\u003eLion’s Mane, Cordyceps and Reishi mushroom powder dosage as a daily supplement should be 1 tsp once or twice a day. Mushroom powders are easy and convenient to use, simply add the mushroom powder to coffee, smoothies, water, tea or use it in your favourite recipes. Click \u003ca href=\"https:\/\/lifecykel.com\/blogs\/recipes\" title=\"Mushroom Recipes\"\u003e\u003cu\u003ehere\u003c\/u\u003e\u003c\/a\u003e to view some of our delicious mushroom recipes for some inspiration!\u003c\/p\u003e\n\u003cp\u003eIf you want to buy Lion’s Mane, Cordyceps or Reishi mushroom powder, Australia’s best organic mushroom powders, you are in the perfect place, browse our collection of mushroom powders below\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e To delve deeper into the world of fungi and to learn more about functional mushrooms, follow this \u003ca href=\"https:\/\/lifecykel.com\/blogs\/mushrooms\" title=\"Mushroom Blog\"\u003e\u003cu\u003elink \u003c\/u\u003e\u003c\/a\u003eto read our latest blogs.\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[1] Bilal, A.W., R, H.B. and A, H.W. (2010). Nutritional and medicinal importance of mushrooms. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Medicinal Plants Research\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 4(24), pp.2598–2604.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[2] Choi, J.-H. (2018). Biologically functional molecules from mushroom-forming fungi. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eBioscience, Biotechnology, and Biochemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 82(3), pp.372–382.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[3] Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R.P., Kuppusamy, U.R., Abdullah, N. and Malek, S.N.A. (2013). Neurotrophic Properties of the Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 15(6), pp.539–554.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[4] Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. and Stadler, M. (2016). Corallocins A–C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the MushroomHericium coralloides. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 79(9), pp.2264-2269.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[5] Chang, S.-T. and Wasser, S.P. (2012). The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 14(2), pp.95–134.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [6] Friedman, M. (2015). Chemistry, Nutrition, and Health-Promoting Properties ofHericium erinaceus(Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 63(32), pp.7108–7123.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[7] Mori, K., Ouchi, K. and Hirasawa, N. (2015). The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eInternational Journal of Medicinal Mushrooms\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(7), pp.609–618.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [8] JIANG, S., WANG, Y. and ZHANG, X. (2016). Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eExperimental and Therapeutic Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 12(1), pp.513–517.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[9] Das, S.K., Masuda, M., Sakurai, A. and Sakakibara, M. (2010). Medicinal uses of the mushroom Cordyceps militaris: Current state and prospects. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eFitoterapia\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 81(8), pp.961–968.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[10] Ko and Leung. Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs. Chin Med. 2007. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[11] Gamage, S., Nakayama, J., Fuyuno, Y. and Ohga, S. (2018). The Effect of the Hot Water Extracts of the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePaecilomyces hepiali \u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003eand \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCordyceps militaris\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e Mycelia on the Growth of Gastrointestinal Bacteria. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdvances in Microbiology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 08(07), pp.490–505.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[12] Kim, S.B., Ahn, B., Kim, M., Ji, H.-J., Shin, S.-K., Hong, I.P., Kim, C.Y., Hwang, B.Y. and Lee, M.K. (2014). Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL\/6J mice. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Ethnopharmacology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 151(1), pp.478–484.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e [13] Isaka, M., Chinthanom, P., Sappan, M., Supothina, S., Vichai, V., Danwisetkanjana, K., Boonpratuang, T., Hyde, K.D. and Choeyklin, R. (2017). Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Natural Products\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 80(5), pp.1361–1369.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[14] Cilerdzic, J., Stajic, M. and Vukojevic, J. (2016). Potential of Submergedly Cultivated Mycelia of Ganoderma spp. as Antioxidant and Antimicrobial Agents. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eCurrent Pharmaceutical Biotechnology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 17(3), pp.275–282.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[15] Wang, C.-H., Hsieh, S.-C., Wang, H.-J., Chen, M.-L., Lin, B.-F., Chiang, B.-H. and Lu, T.-J. (2014). Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Agricultural and Food Chemistry\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 62(3), pp.634–641.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e[16] Chu, Q.-P., Wang, L.-E., Cui, X.-Y., Fu, H.-Z., Lin, Z.-B., Lin, S.-Q. and Zhang, Y.-H. (2007). Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ePharmacology Biochemistry and Behavior\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e, 86(4), pp.693–698.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003c\/details\u003e","published_at":"2018-10-03T17:13:28+10:00","sort_order":"best-selling","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-03T17:17:02+10:00","alt":"","width":2000,"height":1602,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/Powder_Chaga.png?v=1570769090"}},{"id":81919148101,"handle":"our-most-popular-products","title":"Our most popular products","updated_at":"2019-11-12T12:30:03+11:00","body_html":"","published_at":"2018-10-09T20:31:53+11:00","sort_order":"manual","template_suffix":"","published_scope":"web","image":{"created_at":"2018-10-09T21:38:37+11:00","alt":"","width":1000,"height":1061,"src":"https:\/\/cdn.shopify.com\/s\/files\/1\/0051\/1010\/4133\/collections\/mushroom-box-grown_9f7cd2ae-9917-4975-be1f-7e05481b2d9d.jpg?v=1539081517"}}]$29.95 AUD